Contribution of the TIM-3/Gal-9 immune checkpoint to tropical parasitic diseases

Bailly, Christian

doi:10.1016/j.actatropica.2022.106792

Cited by 4 publications

(2 citation statements)

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“…Recently, Bailly classified the Tim-3 receptor as an important checkpoint due to its induction by parasites, particularly P. falciparum or P. vivax, as a strategy to evade the host immune system [70]. Notably, the expression of Tim-3 is upregulated during infection, particularly in cases of acute malaria, and concomitantly, Gal-9 levels also increase.…”

Section: The Role Of Galectins In Plasmodium Infectionmentioning

confidence: 99%

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Galectins in Protozoan Parasitic Diseases: Potential Applications in Diagnostics and Therapeutics

Meira,

Silva,

Quadros

et al. 2023

Cells

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Neglected tropical diseases (NTDs) constitute a group of diseases that generally develop in tropical or subtropical climatic conditions and are related to poverty. Within the spectrum of NTDs, diseases caused by protozoa such as malaria, Chagas disease, and leishmaniasis exhibit elevated mortality rates, thereby constituting a substantial public health concern. Beyond their protozoan etiology, these NTDs share other similarities, such as the challenge of control and the lack of affordable, safe, and effective drugs. In view of the above, the need to explore novel diagnostic predictors and therapeutic targets for the treatment of these parasitic diseases is evident. In this context, galectins are attractive because they are a set of lectins bound to β-galactosides that play key roles in a variety of cellular processes, including host-parasite interaction such as adhesion and entry of parasites into the host cells, and participate in antiparasitic immunity in either a stimulatory or inhibitory manner, especially the galectins-1, -2, -3, and -9. These functions bestow upon galectins significant therapeutic prospects in the context of managing and diagnosing NTDs. Thus, the present review aims to elucidate the potential role of galectins in the diagnosis and treatment of malaria, leishmaniasis, and Chagas disease.

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Section: The Role Of Galectins In Plasmodium Infectionmentioning

confidence: 99%

“…These elevated levels of both Tim-3 and Gal-9 were found to correlate with the severity of the disease [59]. As a result, the upregulation of Tim-3 and Gal-9 during malaria infection can lead to their overexpression, which is associated with tissue damage, particularly in the liver and lungs [70,71].…”

Section: The Role Of Galectins In Plasmodium Infectionmentioning

confidence: 99%