Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells

Parra, Andrés; Rivas, Francisco; Martin-Fonseca, Samuel; Garcı́a-Granados, Andrés; Martı́nez, Antonio

doi:10.1016/j.ejmech.2011.10.011

Cited by 44 publications

(30 citation statements)

References 42 publications

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“…Recent studies have reported evidence for an apoptotic effect of maslinic acid derivatives, showing a correlation between the ability to induce apoptosis and structural modification [8]. Thus, amide and benzyl substitution on the C-28 carboxylic group, and acetoxy on the A-ring hydroxyls, induce apoptosis in N90% of tumor cells, making these compounds notable candidates for further development.…”

Section: Introductionmentioning

confidence: 99%

Interaction between the anti-cancer drug diacetyl maslinic acid and bovine serum albumin: A biophysical study

Molina-Bolı́var

Galisteo‐González

Ruiz

et al. 2015

Journal of Molecular Liquids

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Section: Introductionmentioning

confidence: 99%

Interaction between the anti-cancer drug diacetyl maslinic acid and bovine serum albumin: A biophysical study

Molina-Bolı́var

Galisteo‐González

Ruiz

et al. 2015

Journal of Molecular Liquids

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“…In addition, studies have shown that MA suppressed NF-κB activation (40). In the present study, we investigated the mechanism of how MA enhanced the apoptotic effects of GEM in cultured GBC cells.…”

Section: Discussionmentioning

confidence: 99%

Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-κB-mediated survival signaling pathways in human gallbladder cancer cells

Wang

Xia

et al. 2015

Oncology Reports

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Abstract. Gemcitabine (GEM) is one of the first-line drugs in the treatment of gallbladder cancer (GBC), although the therapeutic effect is not sustained due to resistance to the drug over time. Maslinic acid (MA) has been shown to inhibit transcription factor nuclear factor-κB (NF-κB), resulting in the suppression of survival signaling. The authors of the present study investigated whether MA enhanced the antitumor activity of GEM in GBC. Anti-proliferative effects of MA, GEM and MA + GEM were assessed using the MTT assay. Apoptosis was assessed using Annexin V and by western blot analysis of various mediators of apoptosis. Xenograft tumors of EH-GB2 GBC cells were established in athymic nude mice and were monitored following treatment with MA, GEM and MA + GEM. Immunohistochemistry of the tumors was used to examine various survival proteins. MA inhibited the in vitro proliferation of various GBC cell lines and potentiated the apoptosis and cell invasion inhibition induced by GEM. Western blot analysis showed that the combination of MA and GEM inhibited constitutive NF-κB activation and NF-κB-regulated gene products, including cyclin D1, Bcl-2, Bax, MMP-2 and MMP-9, to a greater extent. In vivo, the group that was treated with MA + GEM showed significant reductions in tumor volume and a decreased expression of NF-κB-regulated gene products. In conclusion, the results suggest that MA potentiates the antitumor effects of GEM in human GBC cell lines by suppressing the activation of NF-κB and its dowstream gene products, which are involved in survival signaling. IntroductionGallbladder cancer (GBC) is the most common cancer of the bile duct system and is the fifth most lethal cancer of the digestive system (1). The incidence of GBC in China, Thailand, Chile and Northern India is higher when compared with the United States and European countries (2). At present, radical surgical resection is the most effective treatment of GBC. However, for the majority of patients, surgery is not curative because of late detection and/or early, regional or distant metastasis. Additionally, few patients experience complete responses to chemotherapy, mainly due to chemoresistance. Thus, identifying novel approaches to enhance the antitumor effects of chemotherapeutic drugs and reduce chemoresistance are imperative.Maslinic acid (MA), a pentacyclic triterpene acid, is widely present in dietary plants, especially in olive fruit skins and hawthorn berries (3). The compound has attracted much interest due to its proven pharmacological safety and its many biological activities, including anticancer such as anti-inflammation (2), anti-viral (4,5), anti-oxidation (6), anti-diabetogenic (7), anticolonic cancer (8,9) and anti-astrocytoma (10) activities. MA has been shown to potentiate the anticancer activity of TNF-α in pancreatic cancer cells through the inhibition of nuclear factor-κB (NF-κB) survival signaling pathways (11).NF-κB is a transcriptional activator that has been extensively studied for its role in controlling the expression of...

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“…To illustrate the point, maslinic acid is a natural pentacyclic triterpene, frequently found in olive oil and medicinal plants such as Aster yunnanensis and Eugenia gustavioides. Maslinic acid and its derivatives had been reported by many research groups with apoptotic activities against different cancer cell lines (Juan et al, 2008;Lin et al, 2014;Parra et al, 2011;Bianka Siewert et al, 2013); however, the exact mechanism remains elusive. Through comparative proteomic study, it was reported that in maslinic acid-treated cancer cells, the expressions of dUTPase and stathmin (two cancer proteins involved in inducing early S and G2 cell cycle arrest) were down-regulated (Yap et al, 2012).…”

Section: Phytochemical-mediated Cancer Protein Targetsmentioning

confidence: 96%

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

Wong

Tan

Chai

2015

Critical Reviews in Food Science and Nutrition

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Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents.

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Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells

Cited by 44 publications

References 42 publications

Interaction between the anti-cancer drug diacetyl maslinic acid and bovine serum albumin: A biophysical study

Interaction between the anti-cancer drug diacetyl maslinic acid and bovine serum albumin: A biophysical study

Maslinic acid potentiates the antitumor activities of gemcitabine in vitro and in vivo by inhibiting NF-κB-mediated survival signaling pathways in human gallbladder cancer cells

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

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