Masaoka Stage and Histologic Grade Predict Prognosis in Patients With Thymic Carcinoma

Hosaka, Yoshitaka; Tsuchida, Masanori; Toyabe, Shin-ichi; Umezu, Hajime; Eimoto, Tadaaki; Hayashi, Jun‐Ichi

doi:10.1016/j.athoracsur.2009.11.057

Cited by 76 publications

(75 citation statements)

References 27 publications

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“…Surgery is typically considered as the first line of treatment, and a multimodality approach is usually recommended [5]. According to the literature, several factors may predict the outcome of thymic carcinoma patients, including completeness of resection, Masaoka stage, histology, tumor size, and lymph node status [6][7][8][9][10]. However, the key factor(s) that determine the prognosis of this disease remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Zhang

et al. 2015

Int J Clin Oncol

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Masaoka stage (P = 0.048), and higher complete resection rates (P = 0.042). However, multivariate analysis demonstrated that complete resection was the only independent predictor for overall survival (OS) (P < 0.001).Conclusions The OS of patients with thymic carcinoma depends on complete resection, but patients with MG also demonstrate improved prognoses. MG patients have higher rates of complete surgical resection, which may account for their better prognoses. Patients with MG have unique features that may aid in the clinical management of these patients.

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Section: Introductionmentioning

confidence: 99%

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Zhang

et al. 2015

Int J Clin Oncol

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“…The Masaoka staging system can also be used to stage thymic carcinomas (see Table 1 in the complete version of these guidelines, available at NCCN.org ). 29,103,104 It is important to note that thymic carcinomas are very different from thymomas. 41 Similar to thymomas, patients with completely resected thymic carcinomas have longer survival than those with either incompletely resected or are unresectable disease.…”

Section: Thymic Carcinomasmentioning

confidence: 99%

Thymomas and Thymic Carcinomas

Ettinger¹,

Riely²,

Akerley³

et al. 2013

J Natl Compr Canc Netw

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“…Los CT (también llamados TM tipo C) son más invasivos que los TM, dan más recurrencias y tienen menor supervivencia 3,5,7,20,[25][26][27] . En 15 de nuestros pacientes, existía infiltración de estructuras vecinas y 8 tenían más de una estructura infiltrada, lo que también se asoció significativamente a la supervivencia.…”

Section: Discussionunclassified

“…La de Masaoka es la más utilizada y aceptada, se basa en el grado de infiltración de la cápsula tumoral y estructuras vecinas. Se define según criterios clínicos y anatomopatológicos y se considera un excelente predictor independiente de supervivencia 1,4,7,8,14,19,21,24,25,29,37 . Sin embargo, de identifican algunos problemas: -No existe mucha diferencia pronóstica entre etapas I y II.…”

Section: Discussionunclassified

“…Para las NET se han descrito variables asociadas a mejor supervivencia como: etapa, grado de resección, infiltración de estructuras vecinas, metástasis linfáticas, metástasis hematógenas y asociación a MG entre otras 1,7,11,12,[23][24][25][26]35,43 . Kondo y col 7 , en una serie multicéntrica de 1.320 pacientes, señala que los mejores factores pronósti-cos para TM son la etapa de Masaoka y la resección completa y para CT la resección completa y las metástasis linfáticas.…”

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Neoplasias epiteliales del timo: timoma y carcinoma tímico: Caracterización, tratamiento y variables asociadas a supervivencia

et al. 2012

Rev Chil Cir

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Thymic epithelial tumors. Retrospective review of 54 patientsBackground: Thymic epithelial tumors are uncommon and can be associated with myasthenia gravis. Aim: To describe variables associated with survival and treatment of thymic epithelial tumors. Material and Methods: Retrospective review of surgical databases of a respiratory diseases hospital, identifying patients operated for a thymic epithelial tumor between 2000 and 2010. Follow up lasted from 12 to 156 months and information was obtained from medical records and death certificates of the Chilean national identification service. Results: Data from 54 patients aged 52.5 ± 16.4 years (33 women) was retrieved. Forty two patients were symptomatic and 47 were subjected to resective surgery. The pathological diagnosis was thymoma in 46 cases and thymic carcinoma in eight. Fourteen patients had postoperative complications and one died. Mean survival time was 101.8 ± 10.2 months. One, three and five years survival was 90.7 ± 3.9, 81.4 ± 5.7 and 71.8 ± 8.2%, respectively. Preoperative performance status of patients, histological type of the tumor and associated myasthenia gravis were predictors of survival. Conclusions: More commonly, thymic epithelial tumors appear in women, their histological type corresponds to thymomas and their resection is feasible

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Masaoka Stage and Histologic Grade Predict Prognosis in Patients With Thymic Carcinoma

Cited by 76 publications

References 27 publications

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Thymomas and Thymic Carcinomas

Neoplasias epiteliales del timo: timoma y carcinoma tímico: Caracterización, tratamiento y variables asociadas a supervivencia

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