Neoplasias epiteliales del timo: timoma y carcinoma tímico: Caracterización, tratamiento y variables asociadas a supervivencia

Abstract

Thymic epithelial tumors. Retrospective review of 54 patientsBackground: Thymic epithelial tumors are uncommon and can be associated with myasthenia gravis. Aim: To describe variables associated with survival and treatment of thymic epithelial tumors. Material and Methods: Retrospective review of surgical databases of a respiratory diseases hospital, identifying patients operated for a thymic epithelial tumor between 2000 and 2010. Follow up lasted from 12 to 156 months and information was obtained from medical records and death certificates of the Chilean national identification service. Results: Data from 54 patients aged 52.5 ± 16.4 years (33 women) was retrieved. Forty two patients were symptomatic and 47 were subjected to resective surgery. The pathological diagnosis was thymoma in 46 cases and thymic carcinoma in eight. Fourteen patients had postoperative complications and one died. Mean survival time was 101.8 ± 10.2 months. One, three and five years survival was 90.7 ± 3.9, 81.4 ± 5.7 and 71.8 ± 8.2%, respectively. Preoperative performance status of patients, histological type of the tumor and associated myasthenia gravis were predictors of survival. Conclusions: More commonly, thymic epithelial tumors appear in women, their histological type corresponds to thymomas and their resection is feasible

Miastenia gravis: resultados inmediatos y alejados de la timectomía transesternal extendida

“…Al comparar la serie total de pacientes con el subgrupo no timomatoso, se observó que estos últimos presentaban una mejor evolución a largo plazo; confirmando lo expuesto en otras series que lo pacientes con timoma y MG poseen características diferentes dado que su pronóstico neurológico es peor, presentando mayor tasa de persistencia de síntomas, crisis miasténicas y requerimientos altos de dosis de anticolinesterásicos. Sin embargo, las neoplasias epiteliales del timo asociada a MG presentan una mayor supervivencia respecto a las otras neoplasias tímicas, esto podría explicarse por la precocidad de los síntomas miasténicos que manifiestan, lo que permite un diagnóstico y tratamiento más oportuno 36,37 .…”

Masa intraauricular derecha en paciente chagásico con marcapasos definitivo

“…Actualmente, con el mayor uso de dispositivos de instalación intracardíaca, catéteres venosos centrales y nutrición parenteral prolongada, la trombosis de la vena cava superior ha aumentado en frecuencia 7 . En el mediastino anterior, los tumores más frecuentes corresponden a los tumores provenientes del timo, pudiendo ascender al 45% [8][9] . Los timomas y los carcinomas tímicos corresponden a Neoplasias Epiteliales del Timo (NET) y son, no obstante, tumores de muy baja prevalencia, representando el 0,06-1,5% de todos los tumores 10 .…”

“…El paciente actualmente tolera el decúbito y la ingurgitación yugular y el edema en esclavina han disminuido considerablemente. superior y síndromes paraneoplásicos distintos de Miastenia gravis 8 (Aplasia pura de la serie roja, inmunodeficiencia, autoinmunidad multiorgánica asociada a Timoma, etc) [11][12] . Los Timomas son de crecimiento más lento que los Carcinomas Tímicos y se asocian a menores tasas de invasión local y metástasis.…”

Thymic minimally invasive surgery: state of the art across the world: Central-South America

“…Unfortunately, the authors did not go into details, but apparently all cases were small encapsulated thymomas. In the last decade, two case series reporting on management and outcomes of thymic tumors in Latin America were published, one in Brazil (16) and one in Chile (17). The Brazilian study included 26 patients with thymic malignancies operated on from 1986 until 2006.…”

“…The Chilean study included 54 patients with thymic tumors (thymomas or thymic carcinomas) from 2000 to 2010, of which 47 underwent resection. Only 9 of the procedures started by VATS, and 3 of them were converted either to sternotomy or thoracotomy (17).…”