Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Lodhi, Santram; Vadnere, Gautam P.; Sharma, Vikas; Usman, Md. Rageeb Md.

doi:10.5455/jice.20170713060840

Cited by 27 publications

(23 citation statements)

References 61 publications

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“…They were evaluated in vitro cytotoxicity of this exract on Human colorectal cancer cells (HCT-116 cell line). Extract was significantly (P<0.05) suppressed cell growth of HTC-116 at concentration of 250 μg/mL [25,26]. Eventhough, GBM is one of the mostly diagnosed and lethal cancers all around the world, relatively, there is no study investigating anti-cancer and anti-oxidant effects of M. vulgare on different GBM cell lines especially hard to treat with standard TMZ therapy.…”

Section: Cell Viability On U87 and Ln229 Glioblastoma Multiforme (Gbmmentioning

confidence: 99%

In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract

Okur¹,

Karakaş²,

Karadağ³

et al. 2019

jrp

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Marrubium vulgare L. (Lamiaceae) is a herbal drug used for centuries for many diseases. In this present study the plant material was acquired from commercial sources in pharma grade (PhEur 8.0) quality. The methanol extract of the aerial parts was evaluated for its in vitro cytotoxic activity by measuring the percentage of viable cells (U87 LN229 and T98G glioblastoma multiforme cell lines) using a luminescence system, and the antioxidant activities by ABTS and DPPH radical scavenging spectrophotometrically. As a result, the methanol extract of M. vulgare showed 48.97 ± 0.82 mg of GA/g corresponding to the total phenolic amounts, and moderate antioxidant activity (1.33 and 2.08) by ABTS • and DPPH • assays. To the best of knowledge, after evaluation of the cytotoxicity on M. vulgare treated U87 (IC50:270.3 μM), LN229 (IC50:343.9 μM) and T98G (336.6 μM) glioblastoma multiforme (GBM) cell lines, significant cytotoxic activities with 69.9% (p= 0.0081) and 71% cell viability (p= 0.0028) was observed in M. vulgare treated U87 and LN229 GBM cell lines, respectively. Overall, further in vitro and in vivo bioactivity studies based on phytochemistry on various M. vulgare preparations are worthwhile in order to discover bioactive secondary metabolites.

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Section: Cell Viability On U87 and Ln229 Glioblastoma Multiforme (Gbmmentioning

confidence: 99%

In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract

Okur¹,

Karakaş²,

Karadağ³

et al. 2019

jrp

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“…Fumaria prrviflora [14] Guiera senegalensis [15] Haplophyllum tuberculum [16] Solanum surattense [17] Phenol and Polyphenols 2,4-Bis (1-phenylethyl) phenol, rosmarinic acid, chlonergic acid, methyl gallate Jatropha curas [4] Mrrrubium vulgare [18] Ricinus communis [19] Indigofera caerulea [20] Steroids Withanolide A, dinoxin B, 17α-hydroxypregnenolone, stigmasta-7,25-diene-3β-ol, calonysterone Daturia innoxi [21] Jatropha curas [4] Senna [22]…”

Section: Resultsmentioning

confidence: 99%

Structure-Based Virtual Screening and Molecular Dynamics of Phytochemicals Derived from Saudi Medicinal Plants to Identify Potential COVID-19 Therapeutics

Alamri

Altharawi²,

Alabbas³

et al. 2020

Preprint

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Coronavirus disease 2019 (COVID-19) has affected almost every country in the world by causing a global pandemic with a high mortality rate. Lack of an effective vaccine and/or antiviral drugs against SARS-CoV-2, the causative agent, has severely hampered the response to this novel coronavirus. Natural products have long been used in traditional medicines to treat various diseases, and purified phytochemicals from medicinal plants provide a valuable scaffold for the discovery of new drug leads. In the present study, we performed a computational screening of an in-house database composed of ~1000 phytochemicals derived from traditional Saudi medicinal plants with recognised antiviral activity. Structure-based virtual screening was carried out against three druggable SARS-CoV-2 targets, viral RNAdependent RNA polymerase (RdRp), 3-chymotrypsin-like cysteine protease (3CLpro) and papain like protease (PLpro) to identify putative inhibitors that could facilitate the development of potential anti-COVID-19 drug candidates. Computational analyses identified three compounds inhibiting each target, with binding affinity scores ranging from-9.9 to -6.5 kcal/mol. Among these, luteolin 7-rutinoside, chrysophanol 8-(6-galloylglucoside) and kaempferol 7-(6’’-galloylglucoside) bound efficiently to RdRp, while chrysophanol 8-(6galloylglucoside), 3,4,5-tri-O-galloylquinic acid and mulberrofuran G interacted strongly with 3CLpro, and withanolide A, isocodonocarpine and calonysterone bound tightly to PLpro. These potential drug candidates will be subjected to further in vitro and in vivo studies and may assist the development of effective anti-COVID-19 drugs.

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“…The content of some species and their biological activities are already well known, such as M. vulgare, which is used in digestive and respiratory systems diseases. There are few reports concerning the cytotoxic effect of Marrubium genus extracts on cancer cells [11,14,28], and this activity is attributed to different groups of compounds. Antineoplastic properties of different plants may be associated with the content of phenolic compounds including PhAs [18].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the wide range of phytochemical components [10], most of the earlier described activities attribute to diterpenoid lactone marrubiin, which is present in high concentrations [13]. Fewer reports concern cytotoxic effects of Marrubium genus extracts against cancer cells [14]. Diterpene compounds exhibit anticancer activity [15]; however, according to the the PubChem BioAssay database for Marrubiin [16], marrubiin did not show any cytotoxic effect against 66 tested cancer cell lines.…”

mentioning

confidence: 99%