Marqueurs sérologiques, ARN viral et génotype du virus de l’hépatite delta chez des patients tunisiens antigène HBs positifs

Djebbi, A.; Rebai, Wafa Kammoun; Bahri, Olfa; Hogga, Nahed; Sadraoui, A.; Triki, Henda

doi:10.1016/j.patbio.2008.09.010

Cited by 11 publications

(4 citation statements)

References 23 publications

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“…In our study, the prevalence of anti-HDV antibodies in inactive HBsAg carriers was 4%. When compared to previous Tunisian studies, our result confirms the declining trend of hepatitis D prevalence from 33% in 1990 ( 17 ) and 16.1% in 1997 ( 11 ) to 6.8% in 2009 ( 16 ). This decrease can be explained by improvements of socioeconomic conditions, awareness of transmitting viruses and above all, a better control of HBV infection and systematic vaccination since 1995.…”

Section: Discussionsupporting

confidence: 87%

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Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia

et al. 2016

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Background:Hepatitis D Virus (HDV) causes accelerated liver diseases in patients with Hepatitis B Virus (HBV) infection. There is lack of data about its prevalence, related risk factors and interaction with HBV carriers in our country.Objectives:The aim of this study was to estimate the prevalence of hepatitis delta and associated risk factors among Hepatitis B surface antigen (HBsAg) and “isolated anti-HBc” profile carriers in central Tunisia.Patients and Methods:In this cross-sectional study, 540 patients with positive HBsAg and 109 “isolated anti-HBc” profile receiving care in a teaching hospital were tested for the presence of HDV serum-markers using commercially available enzyme immunoassay kit. HBV-DNA was detected by nested PCR in “isolated anti-HBc” profile group.Results:Prevalence of HDV was 8.1% in HBsAg carriers group, but it was significantly higher in active than inactive hepatitis (30.2% and 4.5%, respectively, OR = 9, 95% CI: [4.48-18.58]). There was no significant association between studied risk factors and HDV infection. In the “isolated anti-HBc” profile group, prevalence of HDV was 4.6% and HBV-DNA had negative result in all patients with positive results for HDV.Conclusions:Although HDV had low prevalence in our area, it is vital to plan preventive strategies for HDV spread as well as HBV prevention. It is particularly important to suspect HDV infection in active HBV carriers to manage a particularly severe dual infection. HDV infection should be suspected even in negative HBsAg patients having “isolated anti-HBc” profile.

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Section: Discussionsupporting

confidence: 87%

“…Prevalence and risk factors of HDV infection are closely related to those of HBV ( 15 ). Tunisia is an intermediate endemicity area for hepatitis B, but HDV prevalence is not well known in some parts of the country ( 11 , 16 ). In our study, the prevalence of anti-HDV antibodies in inactive HBsAg carriers was 4%.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia

et al. 2016

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“…Thus, the 62 (5, 87-143) studies to be included were identified assessing the HDV prevalence in the EMRO countries and fulfilling inclusion criteria. Out of these,19 studies (95-113) were in Iran, nine studies (129-137) in Saudi Arabia, seven studies (5, 119-124) in Pakistan, six studies (89-94) in Egypt, four studies (138-141) in Tunisia and Somalia (125-128) and two studies (142, 143) in Yemen. There was one study of other countries which consisted of: Afghanistan (87), Djibouti (88), Jordan (114), Kuwait (115), Lebanon (116), Morocco (117), and Oman (118).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Hepatitis D in the Eastern Mediterranean Region: Systematic Review and Meta Analysis

et al. 2013

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BackgroundHepatitis D Virus (HDV) causes the most threatening form of chronic viral hepatitis. To date, there is no overall estimation of HDV prevalence in the Eastern Mediterranean Region Office of WHO (EMRO) countries.ObjectivesTo provide a clear estimation of HDV prevalence in the aforementioned region.Patients and MethodsIn the current systematic review, databases such as PubMed, Embase, Web of sciences and Google scholar were searched Until December 2010. The summary estimate of HDV prevalence in the EMRO region was calculated as an average of the pooled infection prevalence of each country weighted by the ratio of the country’s HBV population to the study’s sample size in the survey data analysis.ResultsWe included 62 eligible studies. The weighted mean of HDV prevalence in the EMRO region was 14.74% (95% CI: 14.73 – 14.77), 27.8% (95% CI: 27.78 – 27.82), 36.57% (95% CI: 36.55 – 36.59) and 16.44%. (95% CI: 16.42 – 16.46) in asymptomatic HBsAg positive carriers, chronic hepatitis patients, cirrhosis/ hepatocellular carcinoma, and high risk group, respectively. Among the asymptomatic HBsAg positive group, HDV prevalence was increased by years in older patients in Saudi Arabia but its prevalence was decreased in Iran. No specific pattern was seen according to chronological analysis during years among the EMRO countries.ConclusionsHDV infection is endemic in the EMRO countries and it is more common among patients with severe forms of hepatitis. Due to the high HDV infection rates in the EMRO countries, we recommend blood screening for HDV infection in this region.

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“…They demonstrated significant association between anti-HDV positivity and the duration of HBsAg carrier status, but no association with age, gender, and HBeAg positivity. In the Northern Africa, in Tunisia, a comparisiontooke place between 176 asymptomatic carriers originated from regions of variable HBV endemic cities and 39 CHB patients with HDV positive serology, and the results showed that the mean age of patients was 5 years higher in the HDV positive subjects than in the global population (26). Similarly, two African studies by Mansour et al (27, 28) in Mauritania, a high endemic area for HDV, found that HDV infection was seen more in older ages.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

Ziaee

Azarkar

2013

Hepat Mon

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BackgroundHepatitis delta virus (HDV) is a defective RNA virus dependent on Hepatitis B virus (HBV) infection for its replication and expression. All patients with HBV infection should be tested for the presence of HDV infection. It is estimated that approximately 5% of hepatitis B surface antigen (HbsAg) carriers in the world are HDV infected patients. HBV-HDV co-infection may lead to more severe acute disease and higher risks of fulminant hepatitis, cirrhosis, and hepatocellular carcinoma than those having HBV infection alone. Also, HBV infected patients with HDV super-infection have a higher rate of progression to chronic disease and serious complications.ObjectivesOur aim was to determine the prevalence of HDV infection among chronic hepatitis B (CHB) patients attending Birjand Hepatitis Clinic, East of Iran.Materials and MethodsA cross-sectional analytical study was conducted on 413 CHB patients in 2012. Serology test for anti-HDV was measured by ELISA in these patients. CHB patients had positive hepatitis B surface antigen for at least 6 months before the study entrance.ResultsThe mean age of CHB patients was 38.5± 11.9 years and 55.9% of them (231 patients) were male. There were 13 cases (3.1%) with HDV infection. There was no association between positive anti-HDV serology and factors such as age, gender, carrier state, liver enzymes, and positive hepatitis B e antigen (HBeAg) serology.ConclusionsAlthough HDV had a low prevalence in our area, it is important for healthcare providers and policy makers to plan preventive strategies for HDV spread as well as HBV prevention programs among high risk population.

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Marqueurs sérologiques, ARN viral et génotype du virus de l’hépatite delta chez des patients tunisiens antigène HBs positifs

Cited by 11 publications

References 23 publications

Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia

Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia

Prevalence of Hepatitis D in the Eastern Mediterranean Region: Systematic Review and Meta Analysis

Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

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