Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

Ziaee, Masood; Azarkar, Ghodsiyeh

doi:10.5812/hepatmon.11168

Cited by 19 publications

(12 citation statements)

References 26 publications

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“…The prevalence of HDV in the present study was similar to reported prevalence in a meta-analysis in Iran, 22 Isfahan (2.9%) 23 and Qom (2%). 13 However, it is lower than the reported prevalence rate in Hamadan (17.3%), 9 Ahvaz (11.5%), 24 Birjand (3.1%), 25 and Tabriz and Tehran (9.3%). 17 The observed difference in the prevalence of HDV infection may be attributable to the differences in the age distribution of studied population, sampling source, geographical region and time of the study.…”

Section: Discussionmentioning

confidence: 76%

Prevalence of hepatitis D virus among HBsAg-positive individuals,2015-2016: Azar cohort study

Pouri

Ghojazadeh

Baiaz

et al. 2020

Health Promot Perspect

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Background: Hepatitis D virus (HDV) is a defective RNA pathogen that requires the presence of the hepatitis B virus (HBV) for infection. Middle East countries are endemic areas for HDV infection. So, it is important to estimate the prevalence of HDV in these countries. This study aimed to estimate the prevalence of HDV in HBsAg positive patients participated in Azar cohort study, North-west of Iran. Methods: In this cross-sectional study, out of 4949 participants of the Azar cohort study, 51HBsAg positive patients were selected. Five participants did not consent to HDV testing. The presence of anti-HDV IgG was checked in 46 patients (13 chronic hepatitis B and 33 inactive chronic hepatitis B) using enzyme-linked immunosorbent assay (ELISA) kit. The serum level of liver enzymes was measured and a questionnaire about risk factors was completed.Results: In this study, the mean age of HBsAg positive patients was 50.06 (SD 9.14) years and41.3% were female. Only one out of 46 patients was positive for HDV infection. Thus, the prevalence of HDV infection among hepatitis B virus surface antigen (HBsAg) positive patients was 2.17% (95% CI: 0.1-11.5). The positive anti-HDV patient was in the inactive chronic hepatitis B state and she had a history of hospitalization and dental procedures. Conclusion: The results showed that the prevalence of HDV infection in HBsAg positive patients was 2.1% that was lower than the reported prevalence in many other regions of Iran. Health policymakers and healthcare providers should design coherent and orderly epidemiological studies for planning and monitoring HDV infection.

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Section: Discussionmentioning

confidence: 76%

Prevalence of hepatitis D virus among HBsAg-positive individuals,2015-2016: Azar cohort study

Pouri

Ghojazadeh

Baiaz

et al. 2020

Health Promot Perspect

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“…Similar findings were reported before by Reinheimer et al [2012] as well as Gish et al [2013] which may be due to increased risk factors for viral acquisition among them. Delta infection was more common in the fourth decade of life as supported by Ziaee and Azarkar [2013], whose patients were in fourth decade as well and Zaidi et al [2010] who reported patients in fifth decade.…”

Section: Discussionmentioning

confidence: 90%

Influence of delta virus infection on the virologic status in Egyptian patients with chronic hepatitis B virus genotype D

Fouad

Abdo

Eldeen

et al. 2015

Journal of Medical Virology

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Hepatitis delta virus (HDV) usually have an unfavorable clinical outcome in chronic hepatitis B virus (HBV) patients. In Egypt, data about epidemiology, the spectrum of disease, and impact of HDV on HBV infection are rare. To assess the prevalence, clinical and virological characteristics of HDV infection among Egyptian patients with chronic HBV. Adult patients with Hepatitis B surface antigen (HBsAg)-positive were evaluated for the presence of HDV using anti HDV-IgG and HDV RNA by RT-PCR. Routine laboratory investigations, genotypes and subtypes for both HBV and HDV, abdominal sonography, and transient elastography (TE) were done. Liver biopsy was performed only in whenever indicated. One hundred and twenty-one treatment-naïve chronic HBV patients were included. Wild HBV genotype-D2 was found in 98.2% and 81.9% were HBeAg negative. Prevalence of HDV was 8.3% by anti-HDV IgG and 9.9% by RT-PCR. Wild HDV genotype-IIb was reported in 83.3%. HDV infection was more common in males, 90.9% of delta patients were HBeAg negative. Compared to the mono-infected HBV, concomitant HBV/HDV infection was not associated with more derangment in ALT nor advanced stage of fibrosis. 66.7% of HDV patients had significantly lower HBV-DNA level compared to the non-delta patients (P < 0.001). HDV is not uncommon in Egypt. HBV genotype-D was associated with HDV genotype-IIb. Delta infection was associated with negative HBeAg status, reduction of HBV replication, but neither influenced the clinical course nor increased significant liver damage risk.

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“…Ziaee et al determined the prevalence of HDV infection among chronic hepatitis B in Birjand and there was an HDV infection rate of 3.1% (26). A long-term protection against HBV for more than 20 years was illustrated by Saffar et al among neonates, who were immunized against HBV and it was very effective in decreasing chronic HBV infection prevalence in young adults, who were vaccinated in Iran.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B Surface Antigen Among People Attending Medical Diagnostic Laboratories in Neyshabur, Northeast of Iran, During Years 2011 to 2015

Salehi

Najafi

2017

Arch Pediatr Infect Dis

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Background: Hepatitis B Virus (HBV) infection remains a public health and health care issue in Iran. Since the data on its outbreak is required for effectual policies, this epidemiological study was performed on population from Neyshabur, where there has been no former epidemiological information. Objectives: This study aimed at investigating the epidemiology of hepatitis B surface antigen among subjects from Neyshabur, from year 2011 to 2015. Methods: The researchers established this study from data collected from a surveillance system. Screening tests were carried out by the Chemioluminsance method. Age, gender, referral year and month were the investigated variables. Data were analyzed by the SPSS-20 software. Results: The prevalence of HBsAg in Neyshabur was 4.11%. In the age group of more than 40 years (1.87%) and females (2.2%) had significantly (P < 0.0001) higher rates of HBV seropositivity. Also the year 2011 (5.26%) and the month of July (0.48%) had the highest prevalence. Conclusions: Hepatitis B Virus (HBV) infection rate was seemingly high in Neyshabur, even higher than other parts of Iran. An immunization program should be continued progressively for high-risk areas, especially the Neyshabur city of Iran.

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Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

Cited by 19 publications

References 26 publications

Prevalence of hepatitis D virus among HBsAg-positive individuals,2015-2016: Azar cohort study

Prevalence of hepatitis D virus among HBsAg-positive individuals,2015-2016: Azar cohort study

Influence of delta virus infection on the virologic status in Egyptian patients with chronic hepatitis B virus genotype D

Prevalence of Hepatitis B Surface Antigen Among People Attending Medical Diagnostic Laboratories in Neyshabur, Northeast of Iran, During Years 2011 to 2015

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