MARP Protein Family: A Possible Role in Molecular Mechanisms of Tumorigenesis

Kojić, Snežana

doi:10.2478/v10011-010-0024-9

Cited by 4 publications

(3 citation statements)

References 55 publications

(61 reference statements)

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“…For example, alpha tocopherol supplementation increased the risk for colorectal adenomas (121). Recent in vitro and in vivo studies have suggested that although beta-carotene itself may act as an anticarcinogen, its oxidized products may facilitate carcinogenesis (122,123). A report by the Food and Nutrition Board of the American National Academy of (86) bacterial meningitis (54) Melatonin neonatal asphyxia (8) epilepsy (70) Folinic acid, betaine and methylcobalamin autism (63) Sciences warns against injudicious, excessive intake of antioxidants such as vitamin E, vitamin C, selenium and carotenoids (124).…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Diagnostic and Therapeutic Significance of the Oxidative Stress Parameters in Children

Bajcetic¹,

Brajovic²,

Korkut-Tešić³

2010

Journal of Medical Biochemistry

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Kratak sadr`aj: Farmakoterapija oboljenja kod dece predstavlja veliki izazov s obzirom da najve}i broj lekova koji se svakodnevno koristi nije pedijatrijski evalurian. Efikasnost terapije zavisi u velikoj meri od poznavanja patofiziolo{kih procesa u organizmu dece razli~itih uzrasta te istra`ivanja u tom pravcu predstavljaju imperativ. Naru{en balans u produkciji slobodnih kiseoni~kih/azotnih vrsta i parametara antioksidantne za{tite zna~ajan je patofiziolo{ki ~inilac brojnih oboljenja (npr. sr~ana insuficijencija, plu}na hiper tenzija, astma, neonatalna sepsa, karcinom i dr.) u razli~i tim de~ijim uzrastnim periodima. Reaktivne kiseoni ~ne/azot ne vrste imaju funkciju signalnih molekula u normal nim fiziolo{kim procesima. Njihova pove}ana produkcija mo`e izazvati o{te}enja koja mogu naru{iti normalne fiziolo{ke procese u }eliji i u krajnjem ishodu izazvati }elijsku smrt. U ovom radu dat je pregledni prikaz dosada{njih ispitivanja parametara oksidativnog stresa kod dece razli~ite starosne dobi za pojedina oboljenja. Tako|e, razmotrili smo sve potencijalne dijagnosti~ke i terapijske mogu}nosti parametara oksidativnog stesa u de~ijem uzrastu.Klju~ne re~i: parametri oksidativnog stresa, antioksidansi, deca.

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Section: Therapeutic Implicationsmentioning

confidence: 99%

Diagnostic and Therapeutic Significance of the Oxidative Stress Parameters in Children

Bajcetic¹,

Brajovic²,

Korkut-Tešić³

2010

Journal of Medical Biochemistry

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“…KRTs are a family of about 30 different related cytoplasmic proteins encoded by multiple genes and constitute the intermediate filaments that are incorporated into the cytoskeleton of almost all epithelial cells (23). KRTs are the major constituents of the normal esophageal epithelium and epithelial cancer (24).…”

Section: Discussionmentioning

confidence: 99%

Differentially Expressed Proteins between Esophageal Squamous Cell Carcinoma and Adjacent Normal Esophageal Tissue

Xiong¹,

Huang²,

Cai³

et al. 2012

Journal of Medical Biochemistry

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Summary: Proteomics was employed to identify the differentially expressed proteins between esophageal squamous cell carcinoma (ESCC) and adjacent normal esophageal tissues. ESCC tissues and adjacent normal tissues were obtained from 10 patients with ESCC and the proteins were extracted and subjected to two-dimensional gel electrophoresis (2-DE). The differentially expressed proteins were identified after image analysis, and matrix assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF-MS) was used to confirm these proteins. Immunohistochemistry was then performed to detect the expressions of HSP27 and ANX1 in ESCC tissues and adjacent normal tissues. A total of 6 differentially expressed proteins were identified by peptide mass fingerprinting, among which SCCA1, KRT4 and ANX1 were down-regulated and TIM1, MnSOD and HSP27 up-regulated in the ESCC. Immuno histochemistry showed HSP27 was highly expressed in the ESCC which, however, had a low expression of ANX1. These findings were consistent with those in proteomics. There were differentially expressed proteins between ESCC and adjacent normal tissues. The investigation of differentially expressed proteins between ESCC and normal esophageal tissue may provide evidence for the molecular pathogenesis of ESCC.Keywords: esophageal squamous cell carcinoma, proteomics, differentially expressed proteins, immunohistochemistry Kratak sadr`aj: Uz pomo} proteomike, identifikovali smo proteine ~ija se ekspresija razlikuje u planocelularnom karcinomu jednjaka (PKJ) i susednim zdravim tkivima jednjaka. Uzorci tkiva PKJ i susednih normalnih tkiva uzeti su od 10 pacijenata sa PKJ a proteini su ekstrahovani i podvrgnuti dvodimenzionalnoj elektroforezi na gelu (2-DE). Proteini sa razli~itom ekspresijom su identifikovani posle analize slika, dok je za njihovo potvr|ivanje upotrebljena tehnika MALDI-TOF-MS (matrix-assisted laser desorption ionisation time-offlight mass spectrometry). Potom su obavljene imunohistohemijske analize kako bi se utvrdile ekspresije HSP27 i ANX1 u tkivima PKJ i susednim normalnim tkivima. Pomo}u tehnike peptide mass fingerprintinga identifikovano je ukupno {est proteina sa razli~itim ekspresijama, od kojih je ekspre sija SCCA1, KRT4 i ANX1 bila sni`ena, a TIM1, MnSOD i HSP21 povi{ena u PKJ. Imunohistohemijsko ispitivanje je pokazalo da je HSP27 veoma izra`en u PKJ, u kom je, me|utim, utvr|ena niska ekspresija ANX1. Ovi rezultati se sla`u sa onima dobijenim pomo}u proteomike. Utvr|eno je da postoje proteini sa razli~itom ekspresijom u PKJ i susednim normalnim tkivima. Istra`ivanje razli~ite ekspresije proteina u PKJ i normalnom tkivu jednjaka mo`e doneti nove dokaze u vezi s molekulskom patogenezom PKJ.Klju~ne re~i: planocelularni karcinom jednjaka, proteomika, proteini s razli~itom ekspresijom, imunohistohemija

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“…The Ankrd23 gene/protein was discovered in muscle and adipose tissue of diabetic mice and Obese Zucker rats . Ankrd1, in cardiac muscle, and Ankrd2, in skeletal muscle, are well‐known muscle stretch proteins that are induced under stress conditions and have gene expression regulatory functions . Ankrd1 and Ankrd2 appear to serve both as structural proteins (along with titin and contractile proteins) and nuclear transcriptional regulators, forming molecular links between myofibrillar stretch‐induced signaling and muscle gene expression.…”

Section: Ext‐induced Adaptations Of Vascular Structure and Function Amentioning

confidence: 99%

Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees

et al. 2017

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EXT-induced arteriolar adaptations in skeletal muscle are heterogeneous because of spatial variations in muscle fiber type composition and fiber recruitment patterns during exercise. The purpose of this report is to summarize a series of experiments conducted to test the hypothesis that changes in vascular gene expression are signaled by alterations in shear stress resulting from increases in blood flow, muscle fiber type composition, and fiber recruitment patterns. We also report results from a follow-up study of Ankrd23, one gene whose expression was changed by EXT. We expected to see differences in magnitude of changes in gene expression along arteriolar trees and between/among arteriolar trees but similar directional changes. However, transcriptional profiles of arterioles/arteries from OLETF rats exposed to END or SIT reveal that EXT does not lead to similar directional changes in the transcriptome among arteriolar trees of different skeletal muscles or along arteriolar trees within a particular muscle. END caused the most changes in gene expression in 2A arterioles of soleus and white gastrocnemius with little to no changes in the FAs. Ingenuity Pathway Analysis across vessels revealed significant changes in gene expression in 18 pathways. EXT increased expression of some genes (Shc1, desert hedgehog protein (Dhh), adenylate cyclase 4 (Adcy4), G protein-binding protein, alpha (Gnat1), and Bcl2l1) in all arterioles examined, but decreased expression of ubiquitin D (Ubd) and cAMP response element modulator (Crem). Many contractile and/or structural protein genes were increased by SIT in the gastrocnemius FA, but the same genes exhibited decreased expression in red gastrocnemius arterioles. Ankrd23 mRNA levels increased with increasing branch order in the gastrocnemius arteriolar tree and were increased 19-fold in gastrocnemius muscle FA by SIT. Follow-up experiments indicate that Ankrd23 mRNA level was increased 14-fold in cannulated gastrocnemius FA when intraluminal pressure was increased from 90 and 180 cm H2O for 4 hours. Also, Ankrd23 mice exhibit limited ability to form collateral arteries following femoral artery occlusion compared to WT mice (angioscore WT=0.18±0.03; Ankrd23 =0.04±0.01). Further research will be required to determine whether Ankrd23 plays an important role in mechanically induced vascular remodeling of the arterial tree in skeletal muscle.

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MARP Protein Family: A Possible Role in Molecular Mechanisms of Tumorigenesis

Cited by 4 publications

References 55 publications

Diagnostic and Therapeutic Significance of the Oxidative Stress Parameters in Children

Diagnostic and Therapeutic Significance of the Oxidative Stress Parameters in Children

Differentially Expressed Proteins between Esophageal Squamous Cell Carcinoma and Adjacent Normal Esophageal Tissue

Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees

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