Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population – the Hoorn Study

Heringa, Sophie M.; Berg, Esther van den; Reijmer, Yaël D.; Nijpels, Giel; Stehouwer, Coen D. A.; Schalkwijk, Casper G.; Teerlink, Tom; Scheffer, P; Hurk, Katja van den; Kappelle, L. Jaap; Dekker, J.M.; Biessels, Geert Jan

doi:10.1016/j.psyneuen.2013.11.011

Cited by 86 publications

(82 citation statements)

References 49 publications

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“…Also a recent study of Hur et al (2014) showed that Type D personality was independently associated with significant immune activation and increased levels of TNF-α activity. Our results expand these findings, by analyzing multiple inflammatory biomarkers and combining them into predefined clusters of conceptually related biomarkers (Heringa et al, 2014).…”

Section: Discussionsupporting

confidence: 72%

“…For reasons of statistical efficiency and to reduce the influence of the biological variability of each measure, an overall standardised sumscore was determined for both inflammation and endothelial dysfunction, according to predefined clusters of conceptually related biomarkers (Heringa et al, 2014). The overall zscores were calculated as follows: for each individual biomarker, a z-score was calculated according to the formula: (individual value/ population mean)/population standard deviation.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Association of Type D personality with increased vulnerability to depression: Is there a role for inflammation or endothelial dysfunction? – The Maastricht Study

Dooren

Verhey

Pouwer

et al. 2016

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 72%

Section: Statistical Analysesmentioning

confidence: 99%

Association of Type D personality with increased vulnerability to depression: Is there a role for inflammation or endothelial dysfunction? – The Maastricht Study

Dooren

Verhey

Pouwer

et al. 2016

Journal of Affective Disorders

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“…There is extensive evidence that IL-6, as a proinflammatory cytokine, may affect brain function and may be involved in pathological neurodegenerative disorders. Studies have reported a positive association between plasma IL-6 level and impairment in a wide range of cognitive domains in humans (Gimeno et al, 2008; Simpson et al, 2013; Heringa et al, 2014). Meanwhile, IL-6 overexpression in the brain of transgenic mice has been shown to cause severe neurological disease (Heyser et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

Shen

Wen

et al. 2017

Front. Pharmacol.

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Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function and induce psychotic states. Neuroinflammation has been suggested to play an important role in neurodegeneration. Meanwhile, ketamine has been shown to modulate the levels of inflammatory cytokines. We hypothesized that the effects of ketamine on the central nervous system are associated with inflammatory cytokines. Therefore, we set out to establish acute and chronic ketamine administration models in C57BL/6 mice, to evaluate spatial recognition memory and emotional response, to analyze the changes in the levels of the inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the mouse hippocampus, employing behavioral tests, Western blot, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry. Our results showed that ketamine at the dose of 60 mg/kg induced spatial recognition memory deficit and reduced anxiety-like behaviors in mice after chronic administration. Moreover, we found that ketamine increased the hippocampal levels of IL-6 and IL-1β after single, multiple and long-term administration in a dose-dependent manner. However, the expression level of TNF-α differed in the mouse hippocampus under different conditions. Single administration of ketamine increased the level of TNF-α, whereas multiple and long-term administration decreased it significantly. We considered that TNF-α expression could be controlled by a bi-directional regulatory pathway, which was associated with the dose and duration of ketamine administration. Our results suggest that the alterations in the levels of inflammatory cytokines IL-6, IL-1β, and TNF-α may be involved in the neurotoxicity of ketamine.

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“…Thus, although activation shares age-related variance in RT, which is specific to the distractor-present trials, the relation between activation and RT is indirect and occurs because both frontal activation and RT increase with age. Years of age, in this context, represents not only the passage of time but also the combined influence of many unmeasured variables in the sensory/motor and central nervous systems, for which age is a proxy (Bishop et al, 2010; Heringa et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Age mediation of frontoparietal activation during visual feature search

Madden¹,

Parks²,

Davis³

et al. 2014

NeuroImage

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Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature search task, detection of a shape singleton. On half of the trials, a salient distractor (a color singleton) was present in the display. The hypothesis was that frontoparietal activation mediated the relation between age and attentional capture by the salient distractor. Participants were healthy, community-dwelling individuals, 21 younger adults (19 – 29 years of age) and 21 older adults (60 – 87 years of age). Top-down attention, in the form of target predictability, was associated with an improvement in search performance that was comparable for younger and older adults. The increase in search reaction time (RT) associated with the salient distractor (attentional capture), standardized to correct for generalized age-related slowing, was greater for older adults than for younger adults. On trials with a color singleton distractor, search RT increased as a function of increasing activation in frontal regions, for both age groups combined, suggesting increased task difficulty. Mediational analyses disconfirmed the hypothesized model, in which frontal activation mediated the age-related increase in attentional capture, but supported an alternative model in which age was a mediator of the relation between frontal activation and capture.

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Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population – the Hoorn Study

Cited by 86 publications

References 49 publications

Association of Type D personality with increased vulnerability to depression: Is there a role for inflammation or endothelial dysfunction? – The Maastricht Study

Association of Type D personality with increased vulnerability to depression: Is there a role for inflammation or endothelial dysfunction? – The Maastricht Study

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

Age mediation of frontoparietal activation during visual feature search

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