Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Seppä, Satu; Voutilainen, Raimo; Tenhola, Sirpa

doi:10.1016/j.jpeds.2015.04.015

Cited by 13 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, evidence on the offspring risk of diabetes is scanty. Studies on premorbid traits such as glucose metabolism remain inconclusive 4, 8, 9. Two studies have assessed T2D as an outcome at mean ages of 473 and 459 years in offspring of mothers with preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Kajantie

Osmond

Eriksson

2017

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Kajantie

Osmond

Eriksson

2017

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

“…11 12 62 In accordance with the results above, a recent study showed that insulin sensitivity measured by QUICKI (the Quantitative Insulin Sensitivity Check Index) in 12-year-old offspring born after preeclampsia didn't differ from those from normotensive pregnancy. 63 Kajantie et al found that there was no association between the risk of developing type 2 diabetes in offspring aged from 50 to 61 years and maternal nonsevere or severe preeclampsia, 64 but it should be interpreted with caution due to limited sample size of preeclampsia.…”

Section: Metabolic Outcome In Offspring Epidemiological Evidencementioning

confidence: 99%

Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

2019

AJP Rep

View full text Add to dashboard Cite

Preeclampsia is a common pregnancy complication which can have adverse impact on both mother and baby. In addition to the short term effects, a large body of epidemiological evidence has found preeclampsia can exert long-lasting effects on mother and offspring. Studies suggest that offspring exposed to preeclampsia are at a higher risk of developing cardiovascular, metabolic, and neurological diseases, as well as other diseases. However, studies investigating the underlying mechanism are limited, the exact mechanism still remains unclear. In this study, we will review the epidemiological evidence and studies exploring the mechanism underlying long-term effects of preeclampsia on offspring. Further studies should be targeted at this field so as to implement effective clinical management to prevent the exposed offspring from potential diseases.

show abstract

“…IGF-1 is expresses in insulin-resistant tissue, it downregulates free fatty acid and increases fatty acid β oxidation during fasting ( Thankamony et al, 2014 ; Li et al, 2021 ). It plays an important role in regulating lipid metabolism and insulin sensitivity ( Seppä et al, 2015 ; Gouda et al, 2019 ), since it effects on glucose homeostasis and associated with insulin resistance ( Li et al, 2011 ; Li et al, 2014 ; Dai et al, 2015 ; Ming et al, 2015 ; Yuan et al, 2015 ; Wei et al, 2018 ; Liao et al, 2019 ; Regué et al, 2019 ; Li et al, 2021 ). Previous studies have been reported that people with a low IGF-1 level are prone to have diabetes mellitus ( Chen et al, 2013 ; Colao et al, 2013 ; Shankar and Li, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Insulin-like Growth Factor-1 rs35767 Polymorphism and Type 2 Diabetes Mellitus Susceptibility: A Meta-Analysis

Zeng

Zou

Zeng³

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Background: Insulin-like growth factor-1 (IGF-1) has been demonstrated to increase fatty acid β oxidation during fasting, and play an important role in regulating lipid metabolism and type 2 diabetes mellitus (T2DM). The rs35767 (T > C) polymorphism, a functional SNP was found in IGF-1 promoter, which may directly affect IGF-1 expression. However, the inconsistent findings showed on the IGF-1 rs35767 polymorphism and T2DM risk.Methods: We performed a comprehensive meta-analysis to estimate the association between the IGF-1 rs35767 and T2DM risk among four genetic models (the allele, additive, recessive and dominant models).Results: A total 49,587 T2DM cases and 97,906 NDM controls were included in the allele model, a total 2256 T2DM cases and 2228 NDM controls were included in the other three genetic models (the additive; recessive and dominant models). In overall analysis, the IGF-1 rs35767 was shown to be significantly associated with increased T2DM risk for the allele model (T vs. C: OR = 1.251, 95% CI: 1.082–1.447, p = 0.002), additive model (homozygote comparisons: TT vs. CC: OR = 2.433, 95% CI: 1.095–5.405, p = 0.029; heterozygote comparisons: TC vs. CC: OR = 1.623, 95% CI: 1.055–2.495, p = 0.027) and dominant model (TT + CT vs. CC: OR = 1.934, 95% CI: 1.148–3.257, p = 0.013) with random effects model. After omitting Gouda’s study could reduce the heterogeneity, especially in the recessive model (TT vs. CC + CT: I2 = 38.7%, p = 0.163), the fixed effects model for recessive effect of the T allele (TT vs. CC + CT) produce results that were of borderline statistical significance (OR = 1.206, 95% CI: 1.004–1.448, p = 0.045). And increasing the risk of T2DM in Uyghur population of subgroup for the allele model.Conclusion: The initial analyses that included all studies showed statistically significant associations between the rs35767 SNP and type 2 diabetes, but after removing the Gouda et al. study produced results that were mostly not statistically significant. Therefore, there is not enough evidence from the results of the meta-analysis to indicate that the rs35767 SNP has a statistically significant association with type 2 diabetes.

show abstract

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Cited by 13 publications

References 35 publications

Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

Association Between Insulin-like Growth Factor-1 rs35767 Polymorphism and Type 2 Diabetes Mellitus Susceptibility: A Meta-Analysis

Contact Info

Product

Resources

About