Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Kajantie, Eero; Osmond, Clive; Eriksson, Johan G.

doi:10.1016/j.ajog.2016.10.041

Cited by 67 publications

(53 citation statements)

References 12 publications

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“…These include infants exposed to maternal pre‐eclampsia. In a subset of the 1934–44 cohort, we previously reported that stroke was predicted by maternal pre‐eclampsia, which was present in 7.8% of those born preterm and 4.5% of those born at term. Should they have been born today, many more would have undergone medically indicated preterm delivery, which could have contributed to increased risk of stroke among those born preterm.…”

Section: Commentmentioning

confidence: 99%

Coronary Heart Disease and Stroke in Adults Born Preterm – The Helsinki Birth Cohort Study

Kajantie

Osmond

Eriksson

2015

Paediatric Perinatal Epid

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We found no increased risk of CHD or stroke up to old age in people born preterm, although women born early preterm had a higher rate of CHD. There is a discrepancy between increased risk factors in younger generations born preterm and little or no increase in manifest disease in older age. Uncovering reasons underlying this discrepancy may give important insights into the prevention of cardiovascular disease.

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Section: Commentmentioning

confidence: 99%

Coronary Heart Disease and Stroke in Adults Born Preterm – The Helsinki Birth Cohort Study

Kajantie

Osmond

Eriksson

2015

Paediatric Perinatal Epid

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“…[2][3][4] HDP have been associated with adverse health outcomes for both mothers and children, including subsequent hypertension and chronic kidney disease for mothers, 5,6 childhood overweight/obesity, type 2 diabetes and attention deficit/hyperactivity disorder (ADHD). [7][8][9] Therefore, it is important to identify the risk factors associated with HDP during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan Birth Cohort Study

Yan

Mao

et al. 2018

Clinical Endocrinology

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“…This susceptibility to cardiorenal and metabolic diseases post–index pregnancy has been attributed to the pathophysiological mechanisms10, 11 initiated by the placental ischemia. In addition to the maternal effects, preeclampsia is highly associated with intrauterine growth restriction12 and developmentally programs the increased risk for cardiovascular disease,13, 14 stroke,15 renal disease,16 and metabolic dysfunction17, 18 in the adult offspring of preeclamptic women 19. Since the resolution of preeclampsia is achieved only through parturition of the ischemic placenta,20 a difficult decision often must be made between inducing early delivery in order to halt the progression of the syndrome in the mother and risking premature birth complications to the fetus 21.…”

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confidence: 99%

A Maternally Sequestered, Biopolymer‐Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia

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Mahdi

Chapman

et al. 2017

JAHA

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BackgroundPreeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology. One of these factors, soluble fms‐like tyrosine kinase‐1, is believed to sequester vascular endothelial growth factor (VEGF), leading to systemic endothelial dysfunction and hypertension. With the goal of targeting soluble fms‐like tyrosine kinase‐1 while simultaneously preventing fetal exposure to VEGF, we fused VEGF to elastin‐like polypeptide, a biopolymer carrier that does not cross the placental barrier (ELP‐VEGF).Methods and Results ELP‐VEGF restored in vitro endothelial cell tube formation in the presence of plasma from placental ischemic rats. Long‐term administered ELP‐VEGF in pregnant rats accumulated in maternal kidneys, aorta, liver, and placenta, but the protein was undetectable in the pups when administered at therapeutic doses in dams. Long‐term administration of ELP‐VEGF in a placental ischemia rat model achieved dose‐dependent attenuation of hypertension, with blood pressure equal to sham controls at a dose of 5 mg/kg per day. ELP‐VEGF infusion increased total plasma soluble fms‐like tyrosine kinase‐1 levels but dramatically reduced free plasma soluble fms‐like tyrosine kinase‐1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling. ELP‐VEGF at up to 5 mg/kg per day had no deleterious effect on maternal or fetal body weight. However, dose‐dependent adverse events were observed, including ascites production and neovascular tissue encapsulation around the minipump.Conclusions ELP‐VEGF has the potential to treat the preeclampsia maternal syndrome, but careful dosing and optimization of the delivery route are necessary.

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Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study

Cited by 67 publications

References 12 publications

Coronary Heart Disease and Stroke in Adults Born Preterm – The Helsinki Birth Cohort Study

Coronary Heart Disease and Stroke in Adults Born Preterm – The Helsinki Birth Cohort Study

Thyroid autoantibodies in pregnancy are associated with hypertensive disorders of pregnancy: Ma'anshan Birth Cohort Study

A Maternally Sequestered, Biopolymer‐Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia

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