Markers of Inflammation Before and After Renal Transplantation

Cueto-Manzano, Alfonso M.; Morales‐Buenrostro, Luis E.; González–Espinoza, Liliana; González-Tableros, Norma; Martín-del-Campo, Fabiola; Correa‐Rotter, Ricardo; Valera, Isela; Alberú, Josefina

doi:10.1097/01.tp.0000164348.16689.03

Cited by 86 publications

(39 citation statements)

References 26 publications

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“…21 Another study showed decreased levels of IL-6 and TNF-α after transplant compared with the baseline values; CRP levels were decreased at 6 months and increased at 12 and 18 months after transplant. 22 In the present study, IL-6 and hsCRP levels significantly decreased, but TNF-α and PTX-3 did not change after transplant (Table 2 and Figure 1).…”

Section: Discussionmentioning

confidence: 63%

Untitled

Gürsu

Çelik²,

Öztürk³

et al. 2014

Exp Clin Transplant

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Objectives: There are numerous changes in inflammatory status that occur after a kidney transplant. Pentraxin 3 is a marker of inflammation, but little information is available about pentraxin 3 levels after a kidney transplant. We evaluated the relation between pentraxin 3 and other inflammatory markers including high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α in kidney transplant recipients. Materials and Methods: Adult patients (40 patients; aged, 18-80 y; mean age, 38 ± 10 y) who had a kidney transplant from living-related donors were studied. Patients who had comorbidities associated with chronic inflammation were excluded. Blood samples were obtained before starting immunosuppressive treatment and 2 months after kidney transplant for measurement of pentraxin 3, high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α levels. Results: After transplant, mean levels of high sensitivity C-reactive protein and interleukin 6 decreased but levels of pentraxin 3 and tumor necrosis factor α did not change. There were significant correlations between interleukin 6 and high sensitivity C-reactive protein before transplant (r = 0.71; P ≤ .0001) and after transplant (r = 0.45; P ≤ .003). There was no correlation between tumor necrosis factor α and high sensitivity C-reactive protein before transplant, but there was a significant correlation between tumor necrosis factor α and high sensitivity C-reactive protein after transplant (r = 0.36; P ≤ .03). There was no correlation between interleukin 6 and pentraxin 3, tumor necrosis factor α and pentraxin 3, or high sensitivity C-reactive protein and pentraxin 3 before or after transplant. Conclusions: After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.

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Section: Discussionmentioning

confidence: 63%

Untitled

Gürsu

Çelik²,

Öztürk³

et al. 2014

Exp Clin Transplant

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“…The IL-6 data are more difficult to assess across diverse populations because of lack of standardized methods (31). However, in the posttransplant recipients, the inflammatory markers CRP and IL-6 have been reported to be elevated in most studies on renal transplant recipients (19,(21)(22)(23)(32)(33)(34)(35)(36), although they are lower than pretransplant values (37).…”

Section: Discussionmentioning

confidence: 99%

Inflammation in Renal Transplantation

Abedini¹,

Holme²,

März³

et al. 2009

Clinical Journal of the American Society of Nephrology

103

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Background and objectives: Renal transplant recipients experience premature cardiovascular disease and death. The association of inflammation, all-cause mortality, and cardiovascular events in renal transplant recipients has not been examined in a large prospective controlled trial.Design, setting, participants, & measurements: ALERT was a randomized, double-blind, placebo-controlled study of the effect of fluvastatin on cardiovascular and renal outcomes in 2102 renal transplant recipients. Patients initially randomized to fluvastatin or placebo in the 5-to 6-yr trial were offered open-label fluvastatin in a 2-yr extension to the original study. The association between inflammation markers, high-sensitivity C-reactive protein (hsCRP), and IL-6 on cardiovascular events and all-cause mortality was investigated.Results: The baseline IL-6 value was 2.9 ؎ 1.9 pg/ml (n ‫؍‬ 1751) and that of hsCRP was 3.8 ؎ 6.7 mg/L (n ‫؍‬ 1910). After adjustment for baseline values for established risk factors, the hazard ratios for a major cardiac event and all-cause mortality for IL-6 were 1.08 [95% confidence interval (CI), 1.01 to 1.15, P ‫؍‬ 0.018] and 1.11 (95% CI, 1.05 to 1.18, P < 0.001), respectively. The adjusted hazard ratio for hsCRP for a cardiovascular event was 1.10 (95% CI, 1.01 to 1.20, P ‫؍‬ 0.027) and for all-cause mortality was 1.15 (95% CI, 1.06 to 1.1.25, P ‫؍‬ 0.049).Conclusions: The inflammation markers IL-6 and hsCRP are independently associated with major cardiovascular events and all-cause mortality in renal transplant recipients.

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“…This has been reported in some studies for levels of C-reactive protein, TNF-alpha, and interlukin-6. 33 Another contributing factor may be a lessening of left ventricular hypertrophy after transplant. Such improvement may decrease the risk of mortality from coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

QT Intervals in Patients Receiving a Renal Transplant

Monfared

Z²,

Salari³

et al. 2012

Exp Clin Transplant

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Objectives: Cardiovascular disease is the mostcommon cause of mortality in patients with endstage renal disease and renal transplant. Prolongation of QTc max and QTc dispersion are risk factors of cardiac arrhythmias and mortality. This study compares the changes of QT parameters before hemodialysis, after hemodialysis, and after renal transplant. Materials and Methods: Patient candidates for renal transplant were selected. Mean serum electrolyte and 12-lead electrocardiogram were recorded (1) immediately, (2) before and, (3) after the last dialysis session before renal transplant, (4) and 2 weeks after a kidney transplant in 34 patients with normal graft function (plasma Cr ≤ 176.8 µmol/L). Each QT interval was corrected for the patient's heart rate using Bazett's formula. The QT parameters (QTd, QTcd, QTc max ) were compared between prehemodialysis, posthemodialysis, and 2 weeks after renal transplant using a paired t test and a general liner model repeated measure. The correlation between QT parameter changes and serum electrolyte and acidbase alternation was analyzed. Results: The corrected maximal QT interval (QTc max ) decreased significantly after successful renal transplant compared to prehemodialysis (P = .002) and posthemodialysis (P = .003) with a paired t test and a General Liner Model Repeated Measure (P < .001) between the 3 groups. Also, the mean of

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Markers of Inflammation Before and After Renal Transplantation

Abstract: Compared with controls, patients displayed an inflammatory phenomenon before receiving RT. Serum CRP decreased significantly after RT, whereas TNFalpha and IL-6 increased.

Cited by 86 publications

References 26 publications

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Inflammation in Renal Transplantation

QT Intervals in Patients Receiving a Renal Transplant

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