Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.

Гусева, Н. Г.; Anikina, N V; Myllylä, Raili; Risteli, Leila; Risteli, Juha; Chochlova, J V; Kivirikko, K.I.; Nassonova, V A

doi:10.1136/ard.50.7.481

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…This study showed that serum collagen type IV fragment NC1 levels in 31 SSc patients were higher than those in controls (12.17 in SSc vs 10.26 ng/mL in controls) . Another report examined serum 7S domain of collagen type IV levels in SSc patients, and the concentration did not correlate positively with any of the laboratory findings . In our study, we used the improved, rapid and sensitive measurement method, which used two different monoclonal antibodies against the 7S domain and TH domain of collagen type IV, and identified that serum collagen type IV levels in SSc and dcSSc patients were higher than those in controls.…”

Section: Discussionmentioning

confidence: 70%

“…With respect to SSc and serum collagen type IV levels, only one English‐language study has reported that serum collagen type IV levels were higher in SSc patients compared with healthy controls . Another study examined serum collagen type IV levels in SSc patients and found that serum collagen type IV did not correlate with any laboratory findings . Therefore, the associations of serum collagen type IV levels with clinical features and laboratory findings of SSc, such as skin fibrosis, vascular disorders and autoantibodies, have not been well studied.…”

Section: Introductionmentioning

confidence: 99%

“…17 Another study examined serum collagen type IV levels in SSc patients and found that serum collagen type IV did not correlate with any laboratory findings. 18 Therefore, the associations of serum collagen type IV levels with clinical features and laboratory findings of SSc, such as skin fibrosis, vascular disorders and autoantibodies, have not been well studied. As collagen type IV around dermal vessels are produced from EC and PC, and affect the homeostasis of surrounding cells, we hypothesized that serum collagen type IV levels and the expression of collagen type IV in the skin may be associated with the microangiopathy and the subsequent development of fibrosis in SSc patients.…”

Section: Introductionmentioning

confidence: 99%

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Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis

Motegi

Sekiguchi

Fujiwara

et al. 2016

The Journal of Dermatology

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Collagen type IV is the primary collagen in the basement membranes around blood vessels and in the dermoepidermal junction in the skin. Perivascular collagen type IV is synthesized by endothelial cells and pericytes, and contributes to the homeostasis and remodeling of blood vessels. It has been well recognized that elevated serum collagen type IV levels are associated with the liver fibrosis. The objective was to examine serum collagen type IV levels and their clinical associations in patients with systemic sclerosis (SSc), and to examine the expression of collagen type IV in the fibrotic skin in SSc. Serum collagen type IV levels in SSc patients and diffuse cutaneous type SSc patients were significantly higher than those in healthy individuals. Serum collagen type IV levels were positively correlated with modified Rodnan total skin score. Serum collagen type IV levels in early stage (disease duration ≤3 years) diffuse cutaneous SSc patients were significantly elevated. Serum collagen type IV levels in SSc patients with digital ulcers (DU) were significantly elevated. In immunohistochemical staining, the expression of collagen type IV around dermal small vessels in the affected skin was reduced compared with those of normal individuals. These results suggest that elevated serum collagen type IV levels may be associated with the skin sclerosis in the early stage of SSc. The measurement of serum collagen type IV levels in SSc patients may be useful as a disease activity marker in skin sclerosis and DU.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis

Motegi

Sekiguchi

Fujiwara

et al. 2016

The Journal of Dermatology

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“…These components are reported to be useful indicators of collagen matrix turnover in other diseases, such as interstitial pneumonia, cardiomyopathy, diabetic nephropathy and systemic sclerosis which are characterised by the accumulation of collagen in the organs (22)(23)(24)(25). Furthermore, elevation of the extracellular matrix components in body fluid was confirmed in patients with carcinomas, including stomach, lung, liver, colon and breast (26)(27)(28).…”

Section: Discussionmentioning

confidence: 79%

Type IV collagen levels are elevated in the serum of patients with peritoneal dissemination of gastric cancer

et al. 2010

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Abstract. Type III procollagen (amino-terminal propeptide of procollagen type III) and type IV collagen are considered to be reliable serum markers for monitoring the progression of liver fibrosis. The peritoneal dissemination of gastric cancer is also characterised by abundant collagen deposition in the peritoneum. The present study was performed to investigate the potential of serum type III procollagen and IV collagen as biomarkers for peritoneal dissemination in gastric cancer. The study population consisted of 117 patients with gastric cancer: 32 patients had peritoneal dissemination which was pathologically diagnosed by laparotomy or laparoscopic examination, while 85 patients (45/40, early/advanced gastric cancer) had no peritoneal dissemination. We measured the serum levels of type III procollagen and type IV collagen in comparison to the commonly accepted tumor markers carcinoembryonic (CEA), carbohydrate antigen (CA)19-9 and CA125. The median type III procollagen levels showed no significant differences between the two groups, whereas the median type IV collagen levels were significantly (201 ng/ml) higher in patients with than in those without peritoneal dissemination (early/advanced gastric cancer, 124/136 ng/ml) (P<0.05). In receiver operating characteristic (ROC) curve analysis, type IV collagen had the largest area under the curve (0.83), followed by CA125 (0.72), CA19-9 (0.64), CEA (0.59) and type III procollagen (0.48). Type IV collagen was an independent marker (P<0.0001, odds ratio 15.7) for predicting peritoneal dissemination along with CA125 (P=0.0086, odds ratio 9.4) based on multivariate logistic regression. In conclusion, serum type IV collagen levels may be significant in the early detection and management of patients with peritoneal dissemination of gastric cancer.

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“…Laminin was shown to be elevated up to fourfold in patients with systemic sclerosis [10] and with toxic goiter [11], and up to twofold in patients with hepatic fibrosis [12,13], several tumours [14,15], essential cryoglobulinemia [16], alcoholic liver disease [17], viral hepatitis [18,19], hepatic schistosomiasis [20] and malaria [21]. In patients with septicaemia, increased serum laminin levels were shown to predict acute respiratory distress syndrome [22].…”

Section: Discussionmentioning

confidence: 99%

High serum laminin concentrations in patients with Candida sepsis

Presterl

Lassnigg

Mueller-Uri

et al. 1999

Eur J Clin Investigation

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Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.

Cited by 17 publications

References 22 publications

Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis

Possible association of elevated serum collagen type IV level with skin sclerosis in systemic sclerosis

Type IV collagen levels are elevated in the serum of patients with peritoneal dissemination of gastric cancer

High serum laminin concentrations in patients with Candida sepsis

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