Markers of Cardiovascular Risk Associated with Pregnancy

Quesada, Odayme; Scantlebury, Dawn C.; Briller, Joan; Michos, Erin D.; Aggarwal, Niti R.

doi:10.1007/s11886-022-01830-1

Cited by 4 publications

(4 citation statements)

References 101 publications

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“…Complications during pregnancy can have long-lasting effects on the health of the child, several risk factors like the obstetric complications as preterm labor and their long-term maternal effects serve as indicators for an elevated risk of acute cardiovascular complications during delivery and pose a long-term risk for CVD for both the mother and the offspring [28,29]. These complications can impact various metabolic traits in the offspring, its fetal growth and development [30].…”

Section: Resultsmentioning

confidence: 99%

Perinatal Factors and its Association with Cardiometabolic Profile in Schoolchildren

Mansour,

Tornquist,

Pfeiffer

et al. 2024

Preprint

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BACKGROUND Developmental origins of health and disease suggests a link between the periconceptual, fetal, and early infant phases of life and the persistent development of metabolic disorders. Therefore, this study aimed to verify the associations between perinatal variables and cardiometabolic profile in school-aged children and adolescents. METHODS Retrospective study that used cross-sectional data from a database of a larger study named “Schoolchildren’s health”. The study was carried out using a sample comprising children and adolescents, ranging from 6 to 17 years old from both genders. All participants were enrolled in private and public schools in the city of Santa Cruz do Sul, Brazil. A self-administered questionnaire was applied to children and parents, then anthropometric measurements of body mass index (BMI), body fat percentage (BF%) and waist circumference (WC) were obtained followed by a cardiorespiratory fitness (CRF) test. The association of perinatal variables with BMI, WC, BF%, and CRF was tested by multiple linear regression, using the “Enter” input method, being the unstandardized coefficient (B) and 95% confidence intervals of the associations were estimated. Data were analyzed with Statistical Package for the Social Sciences software, version 23.0 (IBM, Armonk, NY, USA). Statistical significance was established as p < 0.05. RESULTS A total of 1.431 children and adolescents were evaluated, with 803 (56.1%) of them being females and white subjects (83%) with mean age of 11.48 ± 2.75 years. Associations between perinatal factors and anthropometric measurements were found birth weight (BW) and BMI (B:1.13; 95%CI:0.74;1.51), BW and WC (B:2.20; 95%CI:1.37;3.04), BW and BF% (B:1.84; 95%CI:0.83;2.84). Gestational age also had associations with BMI (B:1.00; 95%CI:0.25;1.74); WC (B:1.88; 95%CI:0.25;3.50) and CRF (B:-168.91; 95%CI:-299.53;-38.29). Complications during pregnancy and BMI (B:0.48; 95%CI:0.02;0.93) and cesarean birth and BMI (B:0.43; 95%CI:0.01;0.86). CONCLUSIONS Associations exist between perinatal factors and future cardiometabolic profile. It is imperative to establish and reinforce efforts geared towards enhancing the health literacy of both adolescent boys and girls, along with pregnant women.

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Section: Resultsmentioning

confidence: 99%

Perinatal Factors and its Association with Cardiometabolic Profile in Schoolchildren

Mansour,

Tornquist,

Pfeiffer

et al. 2024

Preprint

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“…This cytokine imbalance and upregulation of inflammation persists after delivery, resulting in endothelial dysfunction and microvascular dysfunction that underly future CVD. Mothers with preterm birth have a 1.61-fold higher risk for stroke, 2.47-fold risk for ischemic heart disease, 1.79-fold risk for cardiovascular mortality, independent of other cardiovascular risk factors [16]. Maternal HDP also results in an elevated risk of CVD in their offspring [17].…”

Section: Antepartum Complications: Development Of Pregnancy-specific ...mentioning

confidence: 99%

Short and long-term complications of hypertensive disorders of pregnancy: lifelong cardiovascular risks we cannot ignore

Saxon,

Bast,

Chou

2024

Current Opinion in Cardiology

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Purpose of review Hypertensive disorders of pregnancy (HDP) pose a significant threat to maternal cardiovascular health, with emerging research shedding light on the enduring risks beyond the gestational period. This review highlights updates regarding cardiovascular risks associated with HDP and their implications for long-term health. Recent findings Patients with a history of HDP are at an elevated risk of developing chronic hypertension, ischemic heart disease, stroke, valvular heart disease, and heart failure. Not surprisingly, patients with HDP experience higher rates of maternal and fetal adverse events in the antepartum and immediate postpartum periods, with high readmission rates for cardiovascular complications. The high risk of chronic hypertension after a HDP then leads to the development of subclinical disease over 5–10 years with overt cardiovascular disease becoming most prevalent in the decades following pregnancy. Early hypertension management in the antepartum and postpartum periods has lifelong health benefits and highlights the need for seamless postpartum transitions with close blood pressure monitoring and cardiovascular risk mitigation. Summary HDP significantly increases the risk of short and long-term adverse cardiovascular events. Integrated healthcare models that assess and address postpartum cardiovascular risk are necessary to improve the cardiovascular health and longevity of those effected by HDP.

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“…3 Overall, recognizing and managing APOs is an important step in reducing the risk of CVD in women who have experienced these conditions during pregnancy. 28,29 A recent study highlighted that the addition of Adverse Pregnancy Outcomes to the Framingham Risk Score improved the risk estimation of CVD. 27 Furthermore, the risk or the presence of manifest perinatal depression should be accurately counseled.…”

Section: Before Pregnancymentioning

confidence: 99%

“…Overall, recognizing and managing APOs is an important step in reducing the risk of CVD in women who have experienced these conditions during pregnancy 28,29 …”

Section: During Pregnancymentioning

confidence: 99%

Cardiovascular risk stratification in young women: the pivotal role of pregnancy

Mattioli,

Coppi,

Bucciarelli

et al. 2023

Journal of Cardiovascular Medicine

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Markers of Cardiovascular Risk Associated with Pregnancy

Cited by 4 publications

References 101 publications

Perinatal Factors and its Association with Cardiometabolic Profile in Schoolchildren

Perinatal Factors and its Association with Cardiometabolic Profile in Schoolchildren

Short and long-term complications of hypertensive disorders of pregnancy: lifelong cardiovascular risks we cannot ignore

Cardiovascular risk stratification in young women: the pivotal role of pregnancy

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