Markers for cognitive impairments and variability of glycaemia in patients with type 1 diabetes mellitus

Самойлова, Ю. Г.; Rotkank, Maria A.; Жукова, Н. Г.; Матвеева, М.В.; Толмачев, И. В.; Kudlаy, D.А.

doi:10.17116/jnevro20181184148-51

Cited by 13 publications

(3 citation statements)

References 11 publications

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“…These functions are relevant as they involve behaviors such as problem-solving and judgement [19]. Other studied domains of cognitive functions in diabetic patients included: -Impaired executive functions, concept formation, cognitive flexibility, and anticipation [20,21].…”

Section: Impaired Cognitive Functions In Diabetic Patientsmentioning

confidence: 99%

“…Hyperglycemia is found to be associated with cognitive decline in several reports [6,7]. Several studies have shown an association between cognitive impairment and glycated hemoglobin (HbA1c) [6,20,23]. Zheng, et al looked at the probable correlation between levels of HbA1c and long-term cognitive impairment and found that a 1 mmol/mol rising in HbA1c was significantly associated with deterioration in cognitive tests [24].…”

Section: Hyperglycemiamentioning

confidence: 99%

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Cognitive impairment in Diabetes Mellitus

Ragaa¹,

Hamdy

Fawzy³

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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Cognitive function is a broad term that refers to mental processes involved in acquiring knowledge, manipulating information, and reasoning. Preserved cognitive functioning is integral to maintaining a healthy, active, and independent lifestyle. Both type 1 and type 2 diabetes mellitus have been linked with poor cognitive skills performance and proof of abnormalities in brain magnetic resonance imaging's structure and function. Cognitive impairment may happen at the earliest stages of diabetes and deteriorates over time, and significantly influences diabetes control and management. Cognitive impairment's pathophysiology is multifactorial. The pathophysiology might include hyperglycemia, deficiencies in insulin pathways, oxidative stress, neuroinflammation, and mitochondrial dysfunction. Determining the mechanism of impaired cognitive skills in diabetes is crucial for developing new approaches to therapy. This review article aims at revising our knowledge about the correlation between diabetes and cognitive impairment, emphasizing the putative underlying mechanisms.

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Section: Impaired Cognitive Functions In Diabetic Patientsmentioning

confidence: 99%

Section: Hyperglycemiamentioning

confidence: 99%

Cognitive impairment in Diabetes Mellitus

Ragaa¹,

Hamdy

Fawzy³

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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“…Известно, что объем головного мозга связан с нарушениями памяти и снижением скорости полу-чения и обработки информации извне; кроме того, существуют данные об ассоциации этих показателей с гипергликемией [13][14][15]. Особенно хорошо это показано у пациентов с СД 1 типа -выявлено снижение толщины коры лобной и височной долей, подкоркового серого вещества [16].…”

Section: таблица 3 сравнительная характеристика морфометрических покаunclassified

Biochemical and morphometric methods for assessing cognitive impairment in patients with type 2 diabetes

Самойлова¹,

Лейман²,

Тонких³

et al. 2020

Cardiovasc Ther Prev

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Aim. To study the features of biochemical and morphometric parameters in patients with type 2 diabetes (T2D) and cognitive impairment (CI).Material and methods. The experimental group included 72 patients with CI and T2D, the control group − 20 patients with T2D and without CI. We used the Montreal Cognitive Scale (MoCA) to assess the presence of CI. We also evaluated the levels of 1,5-anhydroglucitol (1,5-AG), continuous glucose monitoring (CGM), and data of brain magnetic resonance imaging (MRI).Results. We revealed that patients with T2D and CI have high HbA1c levels, but there was no significant difference of 1,5-AG levels between the groups. In patients with CI, we also established a decrease in gray and white matter surface area, as well as subcortical structures (the hippocampus, nucleus accumbens and putamen on both sides; the amygdala and globus pallidus on the right). The severity of CI correlated with polyneuropathy severity. In patients with proliferative retinopathy, there was a decrease in the volume of the caudate nucleus, globus pallidus, putamen and nucleus accumbens. Conclusion. The study revealed that patients with T2D with CI have worse levels of carbohydrate metabolism parameters, as well as a decrease in the cortical and subcortical brain structures.

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