Marker Selection by Akaike Information Criterion and Bayesian Information Criterion

Li, Wentian; Nyholt, Dale R.

doi:10.1002/gepi.2001.21.s1.s272

Cited by 70 publications

(52 citation statements)

References 8 publications

(9 reference statements)

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“…In Results, we report unadjusted P values. After consideration of SNP genotypes individually, all SNPs remaining significant after adjustment by permutation were included in a stepwise selection model using Akaike's Information Criterion to select the most parsimonious model (27). SNPs that were significant (nominal P < 0.05) after adjustment for each other were included in the final model (28).…”

Section: Methodsmentioning

confidence: 99%

Multiple Independent Genetic Variants in the 8q24 Region Are Associated with Prostate Cancer Risk

Salinas

Kwon

Carlson

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Recently, the 8q24 region has been identified as a prostate cancer susceptibility locus in a genome-wide scan of prostate cancer families in Iceland and an admixture scan of African Americans. Further investigations of variants at 8q24 have shown the existence of additional single nucleotide polymorphisms (SNPs) that enhance prostate cancer risk, suggesting the possibility of multiple regions harboring variants for the disease. In the present population-based study of Caucasians (1,308 cases and 1,266 controls) and African Americans (149 cases and 85 controls), we tested the association between prostate cancer and 23 SNPs in the 8q24 region. Fourteen SNPs in Caucasians and 5 SNPs in African Americans were significantly associated with risk of prostate cancer after adjusting for multiple comparisons; of these, 5 SNPs in Caucasians and 3 in African Americans were independently associated with risk. The strongest association was for rs6983561 (carriers of any C allele) with an odds ratio of 1.6 (95% confidence interval, 1.1-2.1) in Caucasians; variants in rs979200, rs1016343, rs7837328, and rs10090154 were also independently associated with risk. In African Americans, the strongest association was for rs7000448 (carriers of any T allele) with an odds ratio of 3.4 (95% confidence interval, 1.3-8.7). In addition, two SNPs that extend the boundaries of the 8q24 region were significantly associated with risk: rs979200 at the centromeric boundary and rs3891248, located in the first intron of the c-MYC gene (IVS1-355), which identifies a new telomeric boundary. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1203 -13)

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Section: Methodsmentioning

confidence: 99%

Multiple Independent Genetic Variants in the 8q24 Region Are Associated with Prostate Cancer Risk

Salinas

Kwon

Carlson

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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show abstract

“…After consideration of SNP genotypes individually, all significant SNPs were included in a stepwise selection model using Akaike's Information Criterion to select the most parsimonious model (15). SNPs that remained significant (P V 0.05) after adjustment for each other were included in the final model (16).…”

Section: Methodsmentioning

confidence: 99%

Association of Megalin Genetic Polymorphisms with Prostate Cancer Risk and Prognosis

Holt¹,

Karyadi

Kwon

et al. 2008

Clinical Cancer Research

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Purpose: Megalin, an endocytic receptor expressed by prostate epithelial cells, can internalize biologically active androgens bound to sex hormone binding globulin. Genetic variation within megalin could potentially influence levels of steroid hormone uptake. Experimental Design: Forty haplotype-tagging single-nucleotide polymorphisms (htSNP) were analyzed in a population-based, case-control study of 553 Caucasian men who were diagnosed with prostate cancer between the ages of 40 and 64 years from the Seattle-Puget Sound region and 534 control men. Prostate cancer risk was estimated using adjusted unconditional logistic regression for both individual SNPs and haplotypes. Risks of disease recurrence/ progression and prostate-specific cancer mortality were estimated using Cox proportional hazards regression. Results: We found no strong evidence of altered risk of developing prostate cancer for any of the htSNPs when they were assessed individually or in haplotypes. However, three htSNPs were significantly associated with both disease recurrence/progression and mortality. Risk of recurrence/progression alone was also associated with five additional htSNPs, and six other htSNPS showed evidence of modification by primary androgen deprivation therapy. Two additional htSNPs were significantly associated with altered risk of death from prostate cancer. Conclusions: Preliminary results suggest that common genetic variation within the megalin gene could alter both risk of recurrence/progression and prostate-specific cancer mortality. In addition, androgen deprivation therapy effectiveness may be modified by the activity of this gene. To our knowledge, this is the first study that has examined polymorphisms within the megalin gene for associations with prostate cancer risk and outcomes.Androgens are believed to contribute to both the etiology and progression of prostate cancer (1). Previously, it was thought that the only way the androgen hormone entered the cell and became biologically active was after disassociation from its plasma carrier protein, sex hormone binding globulin, and subsequent internalization of the lipophilic compound via free diffusion (2). A recent study by Hammes and colleagues (3) showed that megalin, a member of the LDL receptor gene family located on chromosome 2q24-q31, may play a role in the internalization of androgen into the prostatic cell. These researchers showed that megalin, a multiligand endocytic receptor, carries a specific binding site for androgen still bound to sex hormone binding globulin and serves as an active uptake mechanism of the entire steroid hormone complex. The role of megalin in the uptake of androgen in the mature healthy human prostate cell is not known, but our preliminary immunohistochemical assay studies of megalin gene expression have found increased levels of the protein in malignant relative to benign prostate cells. 5Polymorphisms within the megalin gene [low density lipoprotein -related protein 2 (LRP2)] could potentially alter the activity of the encod...

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“…27 Multivariable regression analysis of the TVR risk was performed with all IL-10 polymorphisms, using a stepwise backward selection algorithm. In the final step, clinical variables associated with TVR, also including age and gender, were entered into the regression model.…”

Section: Methodsmentioning

confidence: 99%

Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention

et al. 2006

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Marker Selection by Akaike Information Criterion and Bayesian Information Criterion

Cited by 70 publications

References 8 publications

Multiple Independent Genetic Variants in the 8q24 Region Are Associated with Prostate Cancer Risk

Multiple Independent Genetic Variants in the 8q24 Region Are Associated with Prostate Cancer Risk

Association of Megalin Genetic Polymorphisms with Prostate Cancer Risk and Prognosis

Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention

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