Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention

Asociación de polimorfismos del gen factor de necrosis tumoral (TNF) con el desarrollo de reestenosis de stent post angioplastía coronaria

“…Monraats et al, 17 llevaron a cabo una investigación exhaustiva respecto a factores inflamatorios genéticos asociados a reestenosis en la población del estudio Determinantes Genéticos de Reestenosis (GENetic DEterminants of Reestenosis, GENDER), consistente en 3,104 pacientes tratados mediante PCI, reportando que variantes de cuatro genes se asociaron con un incremento (receptor β2-adrenérgico) o disminución (CD 14 , Factor estimulante de colonias 2 y eotaxina) en el riesgo de TVR. Adicionalmente, entre los hallazgos se describió que tres genotipos diferentes de la citoquina inmunosupresora IL-10 podrían considerarse como marcadores de riesgo en el desarrollo de reestenosis 30 . Un mediador inflamatorio importante que se ha encontrado elevado tras la lesión vascular es TNF-α, fenómeno que ya ha sido demostrado en modelos animales de denudación por balón de la arteria carótida, reportándose entre los efectos un incremento de cuatro veces su expresión génica al compararse arterias lesionadas con aquellas sin lesión.…”

Candidate Gene Analysis of Arteriovenous Fistula Failure in Hemodialysis Patients

“…The two SNPs in the anti-inflammatory cytokine IL-10 demonstrated a nonsignificant lower risk of AVF failure development, possibly due to lack of power. Remarkably, these two SNPs were shown to increase the risk of coronary restenosis (18) and cardiovascular events during hemodialysis (40). Whether this discrepancy is caused by the differences in the mechanisms of AVF failure and coronary restenosis remains to be elucidated.…”

“…Furthermore, we also selected SNPs that were associated with coronary restenosis (13,17,18) and vascular aneurysm formation (19,20), because underlying mechanisms of these diseases are thought to overlap. A MEDLINE search using keywords including "hemodialysis," "arteriovenous access failure," and "single nucleotide polymorphism" identified six genes previously associated with AV access failure: TNF-a (21), klotho (22), fibrinogen-b (FGB) (23), factor V (24), and matrix metallopeptidase 1 (MMP1) (25).…”

Early Systemic Inflammatory Response to Drug-Eluting Stents Implantation: The Heart of the Difference?

“…On the whole, nowadays it is considered that inflammation plays an important role after PCI with regard to restenosis [7], and this is strengthened by the fact that polymorphisms in genes coding for inflammatory proteins, e.g. TNF-α, IL-10, caspase-1 and colony-stimulating factor 2 (CSF2) have been shown to be associated and causally involved in (clinical) restenosis [2,[8][9][10].…”