Markedly elevated CA19-9 associated with benign ovarian cyst and ascites

Brain, Oliver; Brown, Laura H; Suvarna, Shaila; Chapman, Roger W.

doi:10.1136/bcr.11.2008.1219

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…Brain et al described markedly high levels of 2880 U/mL in a case with ruptured ovarian cyst (mucinous cystadenoma) associated with ascites [ 5 ]. Studies have shown that CA19-9 could be increased in up to 50% of cases of immature cystic teratoma [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Unusually High Levels of CA19-9 Associated with Mature Cystic Teratoma of the Ovary

Madaan

Puri²,

Sharma³

et al. 2014

Case Reports in Obstetrics and Gynecology

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Introduction. Mature cystic teratoma is the benign tumor of the ovary. CA19-9 levels, although a marker of pancreatic malignancy, have been found to be raised in large ovarian mature cystic teratomas. Case Report. We report a case of a young female who had unusually high levels of CA19-9 in the blood associated with large ovarian mature cystic teratoma. The levels returned to normal 12 weeks after cystectomy was performed. Conclusion. This case highlights the fact that although raised tumor marker may be associated with a benign pathology thorough evaluation to rule out malignancy still must be done.

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Section: Discussionmentioning

confidence: 99%

Unusually High Levels of CA19-9 Associated with Mature Cystic Teratoma of the Ovary

Madaan

Puri²,

Sharma³

et al. 2014

Case Reports in Obstetrics and Gynecology

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“…[19] Infrequent causes reported in the literature include sarcoidosis, [20] endometriosis, [21] and ruptured ovarian cyst. [22] It is essential to rule out other common and serious causes before attributing the cause of hemorrhagic ascites to HF. In our patient, peritoneal fluid examinations for AFB, malignant cytology, and bacterial cultures were negative in 3 different samples.…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] Infrequent causes reported in the literature include sarcoidosis, [ 20 ] endometriosis, [ 21 ] and ruptured ovarian cyst. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic ascites as a complication of heart failure: A case report and review of the literature

et al. 2022

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Introduction: Although ascites is a common complication of congestive heart failure, the association between heart failure and hemorrhagic ascites is quite rare.Patient concerns: A 64-year-old woman with recurrent large bloody ascites secondary to heart failure.Diagnosis: Ascitic fluid assessment revealed red blood cells of 75,125/mm 3 and white blood cells of 225/mm 3 . The total protein in the ascitic fluid was 28.7 g/L, with a high serum ascites albumin gradient. Peritoneal fluid examinations for bacterial culture, acid-fast bacilli (smear and culture), and malignant cell cytology were negative. Interventions:The patient was managed with therapeutic paracentesis, aggressive diuresis, and optimization of her heart failure medications.Outcomes: The patient's symptoms improved dramatically and was discharged in a stable condition. Conclusion:Congestive heart failure should be considered as a potential cause of hemorrhagic ascites after ruling out other serious causes.Abbreviations: AFB = acid-fast bacilli, AFP = alpha-fetoprotein, HF = heart failure, NT-proBNP = N-terminal pro-brain-type natriuretic peptide, PET = positron emission tomography, RBC = red blood cells, SAAG = serum ascites albumin gradient, TTE = Transthoracic echocardiography.

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“…[14][15][16][17] In addition, there are reports of CA19.9 being elevated in benign cystadenomas, and endometriosis. 18,19 Hence, we should also consider benign conditions as separate from ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Mucinous Carcinoma in a Pediatric Patient With Maroteaux-Lamy Syndrome

Erdem

Özyörük

2021

Journal of Pediatric Hematology/Oncology

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Mucopolysaccharidoses (MPS) are autosomal recessive lysosomal storage disorder (LSD). Mucinous ovarian cancer is a rare tumor and seldom encounters among adolescents. Here we describe an adolescent female with MPS type VI diagnosed with mucinous ovarian cancer. To our knowledge, this is the first case report of ovarian mucinous carcinoma in a patient with MPS. The association between MPS and cancer has never been described so far, but some LSD are known to have an increased risk of malignancies. The pathogenetic link between LSD and cancer is not well understood. Several potential mechanisms have been proposed for pathogenesis, which include chronic inflammation, abnormal function of activated macrophages, and genetic modifiers. Further studies are required, to understand the role of LSD in cancer.

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Markedly elevated CA19-9 associated with benign ovarian cyst and ascites

Cited by 8 publications

References 8 publications

Unusually High Levels of CA19-9 Associated with Mature Cystic Teratoma of the Ovary

Unusually High Levels of CA19-9 Associated with Mature Cystic Teratoma of the Ovary

Hemorrhagic ascites as a complication of heart failure: A case report and review of the literature

Ovarian Mucinous Carcinoma in a Pediatric Patient With Maroteaux-Lamy Syndrome

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