Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents

Higgins, Victoria; Omidi, Arghavan; Tahmasebi, Houman; Asgari, Shervin; Gordanifar, Kian; Nieuwesteeg, Michelle; Adeli, Khosrow

doi:10.1210/clinem/dgz161

Cited by 23 publications

(15 citation statements)

References 59 publications

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“…Consistent with our findings, there was no association between BMI z score and telomere length in the latter study [51]. Measurement of other characteristics of obesity such as elevated circulating lipids or inflammatory markers, which are observed in children who are obese [52], may assist in identifying childhood traits that are associated with biological/molecular ageing. The study has several strengths.…”

Section: Discussionsupporting

confidence: 85%

The metabolic syndrome in pregnancy and its association with child telomere length

et al. 2020

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Aims/hypothesis The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. Methods The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age. Results In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference −0.36 [95% CI −0.74, 0.01]). Height-and weight-forage , and BMI z scores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy. Conclusions/interpretation Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.

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Section: Discussionsupporting

confidence: 85%

The metabolic syndrome in pregnancy and its association with child telomere length

et al. 2020

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“…Specifically, hyperuricemia was associated with visceral fat accumulation, and reduction in visceral fat was associated with reduction in SU ( 25 ). In subjects with overweight and obesity, hyperuricemia has been frequently observed ( 26 – 28 ). Moreover, hyperuricemia has been reported to have a predictive ability for weight gain ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

et al. 2021

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ObjectiveTo clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout.MethodsWe retrospectively analyzed 237 male gout patients who had two sets of body composition and metabolic measurements within 6 months. Subjects included had all been treated with urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by the medical record). All patients were from the specialty gout clinic of The Affiliated Hospital of Qingdao University. The multiple linear regression model evaluated the relationship between change in SU [ΔSU, (baseline SU) – (final visit SU)] and change in VFA [ΔVFA, (baseline VFA) – (final visit VFA)].ResultsULT resulted in a mean (standard deviation) decrease in SU level (464.22 ± 110.21 μmol/L at baseline, 360.93 ± 91.66 μmol/L at the final visit, p <0.001) accompanied by a decrease in median (interquartile range) VFA [97.30 (81.15–118.55) at baseline, 90.90 (75.85–110.05) at the final visit, p < 0.001]. By multiple regression model, ΔSU was identified to be a significant determinant variable of decrease in VFA (beta, 0.302; p = 0.001).ConclusionsThe decrease in SU level is positively associated with reduced VFA. This finding provides a rationale for clinical trials to affirm whether ULT promotes loss of visceral fat in patients with gout.

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“…Hp is also an acute phase protein that has a myriad of other related functions, including antioxidant activity, antibacterial activity, and protease inhibition ( 30 ). In both humans and mice, Hp has been shown to increase in plasma abundance because of increased adiposity and increased adipose Hp secretion ( 31 , 32 , 33 ). Hp has also been shown in obese rats to increase by twofold when fed a diet that was 10% n-3 PUFA ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Blockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment

Martinez-Huenchullan¹,

Shipsey²,

Hatchwell³

et al. 2021

Molecular & Cellular Proteomics

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The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the over-consumption of a high fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regime for animals on either HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and down-regulation of SERPINA1E, CFD (adipsin). Some of these changes were significantly reverted using exercise as a preventative measure, but not as a treatment regime. To determine if either the intensity, or duration, of exercise influenced the outcome, we compared high-intensity interval training (HIIT) and endurance running. Endurance running slightly out-performed HIIT exercise, but overall, both provided similar reversion in abundance of plasma proteins modulated by the high-fat diet including SERPINA7, APOE, SERPINA1E, and CFD. Finally, we compared the changes induced by over-consumption of HFD to previous data from mice fed an isocaloric high saturated fat (SFA) or polyunsaturated fat (PUFA) diet. This identified several common changes including increased APOC2 and APOE, but also highlighted changes specific for either over-consumption of HFD (ALDOB, SERPINA7, CFD), SFA-based diets (SERPINA1E), or PUFA-based diets (Haptoglobin - Hp). Together, these data highlight the importance of early intervention with exercise to revert HFD-induced phenotypes and suggest some of the molecular mechanisms leading to the changes in the plasma proteome generated by high fat diet consumption. Web-based interactive visualizations are provided for this dataset (larancelab.com/hfd-exercise), which give insight into diet and exercise phenotypic interactions on the plasma proteome.

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Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents

Cited by 23 publications

References 59 publications

The metabolic syndrome in pregnancy and its association with child telomere length

The metabolic syndrome in pregnancy and its association with child telomere length

Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

Blockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment

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