Marked induction of CD4+CD8+ T cells with multifunctional properties by coculturing CD2+ cells with xenogeneic stromal cells

Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion‐associated graft‐versus‐host disease?

“…The presence of such cells has not been described for this mouse model before and we hypothesize that these antigens may have been acquired via trogocytosis, the exchange of surface antigen between interacting cells 21,22 . The environment may also play a role and the interaction with xenogeneic cells could induce expression of these antigens on human cells 23 . In hepatitis C virus–infected individuals, T‐regulatory cells up regulate the expression of mRNA for B‐cell antigens including CD19, 24 indicating the potential for T cells to express CD19.…”

Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products

“…However, the relative increase in CD19+ lymphocytes observed in the previous study was not observed in our study. Our data confirm that specific subsets of untreated donor lymphocytes may expand as reaction to the xenogeneic environment …”