Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion‐associated graft‐versus‐host disease?

Fast, Loren D.; Nevola, Martha; Tavares, Jennifer; Reddy, Heather L.; Goodrich, Raymond P.; Marschner, Susanne

doi:10.1111/j.1537-2995.2012.03715.x

Cited by 73 publications

(81 citation statements)

References 26 publications

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“…Since this limited number of remaining leukocytes may cause TA-GVHD, even leukocyte-reduced PLT concentrates have to be gamma-irradiated [5,6]. For PLTs and plasma, but not for red blood cell concentrates (RBCs), photochemical pathogen reduction technologies like riboflavin plus ultraviolet light irradiation may be an alternative [7,8]. Nonetheless, gamma irradiation is currently the only recommended method to prevent TA-GVHD [3,9,10].…”

Section: Introductionmentioning

confidence: 99%

Transfusion Efficacy of Apheresis Platelet Concentrates Irradiated at the Day of Transfusion Is Significantly Superior Compared to Platelets Irradiated in Advance

Julmy

Ammann

Fontana

et al. 2014

Transfus Med Hemother

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Background: Gamma irradiation is currently the standard care to avoid transfusion-associated graft-versus-host disease. Guidelines on gamma irradiation of blood components state that platelets (PLTs) can be irradiated at any stage in their 5-day storage and can thereafter be stored up to their normal shelf life of 5 days after collection. In this study, we explored whether the timing of irradiation has an effect on transfusion efficacy of apheresis PLT concentrates (APCs). Methods: Based on the 1-hour percent PLT recovery (PPR_1h), transfusion efficacy of 1,000 eligible APCs transfused to 144 children were evaluated retrospectively. PPR_1h was compared in transfused APCs irradiated at the day of transfusion and APCs irradiated in advance. Results: In univariate analysis, transfusion efficacy of APCs irradiated in advance was significantly lower than that of APCs irradiated at the day of transfusion (mean PPR_1h 27.7 vs. 35.0%; p = 0.007). This was confirmed in multivariate analysis (p = 0.030). Compared to non-irradiated APCs, transfusion efficacy of APCs irradiated at the day of transfusion was not significantly inferior (mean difference -2.8%; 95% CI -6.1 to 0.5%; p = 0.092), but APCs irradiated in advance were clearly less efficient (mean difference -8.1%; 95% CI -12.2 to -4.0%; p < 0.001). Conclusion: Our data strongly support that APCs should not be irradiated in advance, i.e., ≥24 h before transfusion.

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Section: Introductionmentioning

confidence: 99%

Transfusion Efficacy of Apheresis Platelet Concentrates Irradiated at the Day of Transfusion Is Significantly Superior Compared to Platelets Irradiated in Advance

Julmy

Ammann

Fontana

et al. 2014

Transfus Med Hemother

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“…Therefore, gamma irradiation for blood components remains the main strategy to prevent TA-GVHD in clinical practice (16) . Whole blood treatment with riboflavin and ultraviolet light can also be an alternative to gamma irradiation (17) . Animal models should be established to investigate diseases because of high mortality, low incidence, and unsatisfactory treatment.…”

Section: Discussionmentioning

confidence: 99%

Anti-CD3 Antibody Ameliorates Transfusion-Associated Graft-Versus-Host Disease in a Chemotherapy-Based Mouse Model With Busulfan and Fludarabine

Song

et al. 2017

Braz. arch. biol. technol.

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“…Other benefits are those derived from the inactivation of leukocytes that are not removed by leukoreduction [10]. Essentially, preventing alloimmunization of leukocyte-borne antigens, and eliminating the risk of transfusion-associated graft-versus-host disease are important advantages of riboflavin- and UV light-based PRT [11,12,13]. …”

Section: Discussionmentioning

confidence: 99%

Role of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury

Jimenez‐Marco

Ruiz-Alderton

Bautista-Gili

et al. 2014

Transfus Med Hemother

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Introduction: Risk reduction strategies for transfusion-related acute lung injury (TRALI) include the preferential use of male donors to provide fresh frozen plasma (FFP). Implementing this measure based on FFP quarantine program is a very complex process. To improve FFP inventory management and the availability of FFP from male donors, the Mirasol Pathogen Reduction Technology® (PRT) system for FFP using riboflavin and UV light was adopted in our region in 2012. Methods: The percentage of male/female FFP units issued and TRALI cases in patients receiving FFP in the period before implementing riboflavin and UV light (2010-2011) was compared with the period post implementation of riboflavin and UV light (2012-2013). Results: In 2010 and 2011, there was one FFP transfusion-related TRALI case reported per year, when the proportion of male/female FFP distributed to the hospitals was 60/40. During 2012 and 2013, there have been no FFP transfusion-related TRALI cases, when the proportion of male/female FFP distributed to the hospitals was around 97/3. Mirasol PRT allows quick availability (24 h from collection) compared to quarantined FFP (≥3 months from collection). Conclusion: Thanks to its readiness, simplicity and feasibility, riboflavin- and UV light-treated FFP implementation can facilitate the preferential use of FFP from male donors as a TRALI prevention strategy.

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Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion‐associated graft‐versus‐host disease?

Abstract: The ability to effectively inactivate WBCs in fresh whole blood using Rb-UV, prior to separation into components, provides the transfusion medicine community with a potential alternative to gamma irradiation.

Cited by 73 publications

References 26 publications

Transfusion Efficacy of Apheresis Platelet Concentrates Irradiated at the Day of Transfusion Is Significantly Superior Compared to Platelets Irradiated in Advance

Transfusion Efficacy of Apheresis Platelet Concentrates Irradiated at the Day of Transfusion Is Significantly Superior Compared to Platelets Irradiated in Advance

Anti-CD3 Antibody Ameliorates Transfusion-Associated Graft-Versus-Host Disease in a Chemotherapy-Based Mouse Model With Busulfan and Fludarabine

Role of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury

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