Marked increase in steady-state serum levels achieved with itraconazole oral solution compared with capsule formulation

Freeman, J. V.; Heshmati, Amy; Holland, David; Ticehurst, Rob; Lang, S. D. R.

doi:10.1093/jac/dkm272

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…In cases of mild‐to‐moderate disease, initial therapy with oral itraconazole is sufficient if there is no central nervous system involvement. Itraconazole solution is preferred over capsules for initial therapy, because of more reliable absorption . Once the patient is clinically stable it is common to step down to less expensive and better tolerated capsules taken with food.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous presentation of progressive disseminated histoplasmosis nine years after renal transplantation

Rosado-Odom

Daoud

Johnson

et al. 2013

Transplant Infectious Dis

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Initial presentation of invasive fungal infections such as histoplasmosis can include non-specific clinical manifestations, especially in immunocompromised patients. A high index of suspicion is required to identify atypical manifestations of these diseases, which carry a high risk of mortality, if the diagnosis is delayed or missed. We describe a case of a kidney transplant recipient with cutaneous lesions as initial manifestation of progressive disseminated histoplasmosis where a skin biopsy was crucial to an early diagnosis.

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Section: Discussionmentioning

confidence: 99%

Cutaneous presentation of progressive disseminated histoplasmosis nine years after renal transplantation

Rosado-Odom

Daoud

Johnson

et al. 2013

Transplant Infectious Dis

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“…Coadministration of a proton pump inhibitor (PPI), H2 blocker, or antacid with itraconazole capsules reduces absorption up to 59% in healthy volunteers [47,48]. The β-cyclodextrin solubilized itraconazole oral solution improves absorption by up to 35% compared with capsules and should be taken on an empty stomach to improve absorption [49,50]. Poor palatability, nausea, vomiting, and diarrhea are worrisome GI side effects that may compromise patient compliance.…”

Section: Itraconazolementioning

confidence: 99%

Update on Antifungal Drug Dosing and Therapeutic Drug Monitoring

Trifilio

2011

Curr Fungal Infect Rep

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The prevention and treatment of invasive fungal infections can be compromised by antifungal agents that display unpredictable pharmacokinetics and significant drug interactions and which demonstrate a strong relationship between drug exposure and efficacy and toxicity. Clinical studies have shown that maintaining antifungal drug levels within a targeted range decreases the risk for treatment failure and drug toxicity and thus have established a role for therapeutic drug monitoring with the use of various agents. Evidence from experimental and clinical studies supporting the role of therapeutic drug monitoring and practical applications for attaining targeted levels are reviewed.

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Antifungal Therapeutic Drug Monitoring for Invasive Aspergillosis

Howard

Hope

2009

Aspergillosis: From Diagnosis to Prevention

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Marked increase in steady-state serum levels achieved with itraconazole oral solution compared with capsule formulation

Cited by 5 publications

References 3 publications

Cutaneous presentation of progressive disseminated histoplasmosis nine years after renal transplantation

Cutaneous presentation of progressive disseminated histoplasmosis nine years after renal transplantation

Update on Antifungal Drug Dosing and Therapeutic Drug Monitoring

Antifungal Therapeutic Drug Monitoring for Invasive Aspergillosis

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