Antifungal Therapeutic Drug Monitoring for Invasive Aspergillosis

Voriconazole therapeutic drug monitoring: focus on safety

“…Since steady-state plasma voriconazole concentrations are usually achieved within 5 -6 days (earlier if a loading dose is given), determination of the first level in the first 5 -7 days of therapy is probably reasonable [51]. Although there is no clear threshold for maximum voriconazole plasma concentrations, a cut-off of 5 -6 µg/ml is probably a reasonable choice.…”

“…The main techniques presently used are high-liquid chromatography (HPLC), associated with spectrophotometric or mass-spectrometric detection, and microbiological assays [50]. The limit of detection of these assays ranges from 0.01 -0.03 µg/ml (chromatographic methods) to~0.1 (bioassay) [51].…”