Marked improvement of vulvovaginitis of unknown origin in a pediatric patient - case report

Check, Jerome H.; Cohen, Rachael

doi:10.12891/ceog15982014

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Dextroamphetamine sulfate was found to be highly eff ective for various types of pelvic pain including chronic pelvic pain, mittelschmerz, dyspareunia, vulvovaginitis, dysmenorrhea, and vaginismus [38][39][40][41][42].…”

Section: Dopaminergic Drugs To Treat Medical Conditions Only Found In...mentioning

confidence: 99%

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

H Check*

2024

J Biomed Res Environ Sci

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Based on a conglomeration of basic science research studies a model of hypothetical mechanisms of how the fetal semi-allograft can develop into a live baby was created. One of the tenets of the model is that it is necessary to remodel some of the typically thick-walled uterine arteries found during the proliferative phase into thin-walled spiral arteries to allow nutrient exchange between mother and fetus through an autoimmune mechanism during the luteal phase. The model suggests that the rise in progesterone inhibits dopamine. One function of dopamine is to diminish cellular permeability allowing irritants to infuse into the endometrium thus evoking an inflammatory reaction. The body must suppress these cellular immune cells from attacking the fetus. Progesterone activates membrane progesterone receptors which produces immunomodulatory proteins e.g., the Progesterone Induced Blocking Factor (PIBF), which negates the killing effect of cellular immunity. One hypothesis suggested that PIBF may be secreted by malignant tumors facilitating these tumors with foreign antigens to escape immunosurveillance and thus metastasize. Progesterone receptor antagonists e.g., mifepristone, which suppresses PIBF, have successfully increased length and quality of life in patients with a large variety of end stage treatment resistant cancers. Excessive permeability of various tissues was hypothesized to be related to possible relative deficiency of dopamine. A large variety of medical conditions have been ameliorated significantly by the use of dopaminergic drugs e.g. dextroamphetamine or cabergoline. The model explains why certain conditions may get worse premenstrually e.g., pelvic pain or headaches by the added suppressive effect of progesterone on dopamine. Though possibly further research may modify this model, based on the present hypothesis, a large number of treatment refractory conditions had very successful improvement based on treating with drug releasing dopamine thus correcting tissue permeability disorders.

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Section: Dopaminergic Drugs To Treat Medical Conditions Only Found In...mentioning

confidence: 99%

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

H Check*

2024

J Biomed Res Environ Sci

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“…One may present with chronic introital pain which has also been found to respond dramatically to sympathomimetic amine therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine

Jh¹

2016

Clin. Exp. Obstet. Gynecol.

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To describe a cause and treatment for chronic unremitting lower abdominal pain of long duration with unknown origin. Materials and Methods: A 50-year-old woman with 30 years of unexplained right lower quadrant pain was treated with dextroamphetamine sulfate. Results: Dramatic complete abrogation of the pain occurred within two weeks. The complete relief persisted for two years while she remains on therapy. Conclusions: Symphathetic neural hyperalgesia edema syndrome should be considered whenever there is refractory pelvic or abdominal pain.

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“…There are various types of pelvic pain including dysmenorrhea, dyspareunia, middleschmertz, chronic pelvic pain, introital pain (vulvodynia or vulvovaginosis), and pelvic pain of bladder origin. Dextroamphetamine sulfate has been found to be a very safe and very effective treatment for all of these disorders [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Resolution of pelvic pain related to adenomyosis following treatment with dextroamphetamine sulfate

Jh¹,

Jaffe²

2015

Clin. Exp. Obstet. Gynecol.

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To determine if treatment with dextroamphetamine sulfate can reduce pelvic pain that was attributed to adenomyosis. Materials and Methods: Dextroamphetamine sulfate was given to a 32-year-old woman who suffered on a daily basis from severe chronic pelvic pain that was not relieved by laparoscopic removal of endometriosis by oral contraceptive and ibuprofen. The adenomyosis was diagnosed by magnetic resonance imaging. Results: Within three months the pain was completely gone and has remained absent for six months. Conclusions: Dextroamphetamine sulfate relieved pain from adenomyosis similar to its effect on endometriosis.

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Marked improvement of vulvovaginitis of unknown origin in a pediatric patient - case report

Cited by 5 publications

References 5 publications

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine

Resolution of pelvic pain related to adenomyosis following treatment with dextroamphetamine sulfate

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