Marked elevation of serum mitochondrion‐derived markers in mild models of non‐alcoholic steatohepatitis in rats

Abstract

These observations show that serum mitochondrial enzyme markers are potent markers for non-alcoholic steatohepatitis in rats and are possibly applicable to humans.

Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice

“…Murayama et al . evaluated serum hepatic injury markers for the detection of NAFLD and found that GDH, which is specific to mitochondria and located in the matrix, is a more sensitive marker than cytosolic enzymes such as ALT . In this study, HFD‐fed mice showed significant decreases in hepatic GDH activity and GSH level, and increase in hepatic MDA level.…”

Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice

“…We have recently shown the universal superiority of OCT in the detection of toxicant‐ and alcohol‐induced liver damage in rats over serum cytosol‐derived markers, such as ALT 13,14,18 . Further, OCT proved to be more sensitive than ALT in the detection of liver damage in NAFLD models induced by a choline‐deficient diet and a drug that inhibited mitochondrial function 19 . These observations and the results of this study support the idea that OCT is a sensitive marker that reflects TNF‐α‐mediated liver damage and would be useful in the diagnosis and follow up of NAFLD.…”

“…Recently, we have shown that OCT is the most sensitive marker in alcohol‐induced liver injury in rats, 18 which is generally accepted to have a common pathogenetic mechanism with NAFLD. In addition, marked elevation of OCT was observed in a mild model of NAFLD, including choline‐deficient diet feeding and a drug‐induced mitochondrial injury model; 19 therefore, the usefulness of OCT in another model where its pathogenesis is similar to human NAFLD is desired to confirm the universal superiority of OCT in the diagnosis of NAFLD having features of metabolic syndrome. In the present study, the clinical usefulness of OCT in NAFLD was further examined using diabetic obese mice.…”