Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance

Wang, Wei; Zhang, Yifan; Ding, Mengnan; Huang, Xin; Zhang, Min; Gu, Yu Bei; Wu, Lin; Zhang, Chongchong; Lu, Chunfeng; Shen, Beifen; Chen, Xing; Song, Lun

doi:10.1016/j.bbrc.2021.04.100

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…To clarify the potential effects of SF on PND, 15-month-old mice (threshold age according to Experiment 1) were exposed to 3 consecutive days of SF, which has been proven to reliably interfere with the sleep rhythms of mice [24], and then underwent surgery and anesthesia as previously described. Our results revealed that 15-month-old mice with preoperative SF showed cognitive decline and impaired spatial memory (Table 2), as indicated by less time spent in the new location and a decreased difference recognition index in the OPR test compared with the mice that only received surgery or SF (Figure 3C).…”

Section: Preoperative Sf Increased Susceptibility To Pndmentioning

confidence: 99%

A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation

Liang

et al. 2023

Exp. Anim.

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Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models of PND are usually induced in mice over 18 months of age, which imposes expensive economic and time costs for PND-related studies. Sleep disorders, including sleep fragmentation, are reported to aggravate memory impairment in neurocognitive-related diseases such as Alzheimer's disease (AD). Therefore the aim of the present study was to explore whether a PND model could be constructed in younger mice with the help of fragmented sleep. We found that fragmented sleep followed by laparotomy under isoflurane anesthesia could stably induce PND in 15-month-old mice. To determine whether the neurocognitive decline in this model could be salvaged by clinical treatments, we administered repetitive transcranial magnetic stimulation (rTMS) to the model mice before anesthesia and surgery. We found that 10 days of high-frequency rTMS (HF-rTMS) could improve spatial learning and memory deficits in this modified PND model. We are the first to successfully construct a PND model in younger mice，which is more economical, that can be used as an alternative model for future PND studies.

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Section: Preoperative Sf Increased Susceptibility To Pndmentioning

confidence: 99%

A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation

Liang

et al. 2023

Exp. Anim.

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Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation

Wang,

Liu,

et al. 2024

J Physiol Biochem

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Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance

Cited by 2 publications

References 23 publications

A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation

A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation

Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation

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