Marjolin's ulcer

Browne, Harold R.

doi:10.1016/s0002-9610(41)90400-2

Cited by 8 publications

(3 citation statements)

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“…In such ulcers, repeated incomplete epithelialization attempts, called Marjolin's ulcer, cause malignant degeneration after a long period of time [ 6 ]. Marjolin's ulcer refers to all malignant tumors that occur in chronic ulcers, scars, and inflammation areas [ 2 7 ]. Jean Nicholas Marjolin first illustrated tumorous changes in chronic burn scars in 1828 [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Marjolin's ulcer refers to all malignant tumors that occur in chronic ulcers, scars, and inflammation areas [ 2 7 ]. Jean Nicholas Marjolin first illustrated tumorous changes in chronic burn scars in 1828 [ 2 ]. Treatment involves a wide surgical excision with a range of at least 2 cm, including thick scar tissue in the margin of the ulcer [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Marjolin's ulcer is an aggressive and malignant tumor that creates ulcers in external wounds, with the occurrence of chronic inflammation, scarred skin, and so on. The lesion was named after a French surgeon, Jean-Nicolas Marjolin, who first described the condition in 1828 [ 1 2 ]. Although metastasis to other parts of the body is rare compared with other malignant tumors as a result of the limited supply of blood due to surrounding scars, it progresses rapidly and presents a high mortality rate once metastasis occurs [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Disturbed Wound Healing after Surgery on the Prognosis of Marjolin's Ulcer

et al. 2013

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BackgroundMarjolin's ulcer is known to present a high proportion of recurrence and poor prognosis compared to other kinds of skin cancer. Based on our experience, Marjolin's ulcer patients who have received reconstructive surgery present a higher proportion of recurrence when there was disturbed wound healing after surgery. The impact of disturbed wound healing after surgery on the prognosis was examined in this study.MethodsA retrospective study was carried out on 26 patients who were diagnosed with Marjolin's ulcer and received surgery in this hospital from 1996 to 2011. Histologic grading, lymph node metastasis at diagnosis, and the wound healing process were evaluated and chi-squared analysis applied in order to determine the correlation with recurrence.ResultsThe proportion of recurrence increases in patients with a low histologic grade or lymph node metastasis at diagnosis. The proportion of recurrence is even higher when the problem occurs during the wound healing process after surgery.ConclusionsDisturbed wound healing after surgery could be used as a sign to quickly identify the recurrence of carcinoma. Therefore, in the event a problem occurs in the wound healing process after surgery, one should keep in mind that this could be a sign of the possibility of recurrence and proceed with careful observation and active diagnosis through additional physical examinations, general X-ray tests, computed tomographys, magnetic resonance imagings, and so on, to obtain an early diagnosis of recurrence.

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Section: Discussionmentioning

confidence: 99%