Impact of Disturbed Wound Healing after Surgery on the Prognosis of Marjolin's Ulcer

Choi, Jae Yeon; Bae, Yong Chan; Nam, Su Bong; Bae, Seong Hwan

doi:10.5999/aps.2013.40.3.198

Cited by 22 publications

(24 citation statements)

References 13 publications

(17 reference statements)

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“…7,8 Recurrence is the major problem associated with MU; 46% of our patients suffered local recurrence and 19% suffered more than one recurrence. Three important predictors of recurrence were found in our study: (i) age at the diagnosis (the younger the age the greater was the risk of recurrence); (ii) nodal status (positive nodes were associated with recurrence); (iii) reconstruction with a flap or graft (those who underwent healing by primary/secondary intention without reconstruction carried a lower risk of recurrence).…”

Section: Discussionmentioning

confidence: 82%

“…The relationship between reconstruction and an increased incidence of recurrence was reported first by Choi and colleagues, who concluded that reconstructive surgery with disturbed wound healing was accompanied by recurrence of carcinoma. 8 Unfortunately, they did not make a comparison with patients who underwent excision without reconstruction. Treatment of deep burns with skin grafting is known to reduce the risk of malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Metwally

Roshdy

Saleh

et al. 2017

annals

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INTRODUCTION Marjolin's ulcer (MU) is an uncommon malignancy occurring on top of old scars. Once thought to be more common in Caucasians, is now detected increasingly in Africa. METHODS This was a retrospective study of patients with MU attending a tertiary centre within Mansoura University (Egypt) from 2004 to 2015. An institutional-based registry of skin and soft-tissue malignancies in this period revealed 560 cases, from which there were 26 cases of MU. RESULTS The most common underlying cause of MU was burns (92% of patients), followed by trauma. A predilection towards males was detected. The latent period was 4-70 (median, 25) years. Recurrence occurred in 12 cases, with multiple recurrences occurring in 5 cases. MU recurrence was noted as early as 3 months and as late as 25 years after surgery. CONCLUSIONS Young patients with MU are at higher risk of recurrence and should be followed up closely. A thorough search for nodal metastasis (especially in those with high-grade tumours) should be done. Wide local excision and leaving wounds to heal by secondary intention seems to be a viable treatment option.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Metwally

Roshdy

Saleh

et al. 2017

annals

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“…Following these two references, the term Marjolin’s ulcer became generally accepted and continues to be used in the literature even today. At present the name is used for all neoplasms growing in scar tissues, chronic ulcers, and areas affected by inflammation [ 9 , 10 ].…”

Section: Historymentioning

confidence: 99%

Marjolin’s ulcer in chronic wounds – review of available literature

Bazaliński¹,

Przybek-Mita²,

Barańska³

et al. 2017

113

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Marjolin’s ulcer is a rare, aggressive skin cancer developing in scar tissue, chronic ulcers and areas affected by inflammations. Its incidence is estimated to range from 1% to 2% of all burn scars. It most frequently takes the form of squamous cell carcinoma which sometimes is diagnosed during examination of lesions developing in scars and hard-to-heal chronic wounds (pressure sores, leg ulcers). Therapeutic management of Marjolin’s ulcer requires well-designed treatment plan to ensure optimal medical care and good quality of life for the patient. The high risk of metastases and damage to the structure of vitally important organs determines the need for early diagnosis and prompt surgical intervention with supplementary therapy.The purpose of the study was to examine etiopathogenesis of Marjolin’s ulcer and principles of its treatment. The authors focused on the aspect of malignant degeneration in chronic wounds (leg ulcers, pressure sores) as a very rare, aggressive form of Marjolin’s ulcer. A review of the available literature on the issue of Marjolin ulcers was conducted using the key words; Marjolin ulcers, pressure sore, chronic wound. Malignant degeneration in chronic wounds is a very rare aggressive form of Marjolin ulcer.Increased oncological alertness should be displayed by nursing and medical personnel taking care of patients with chronic wounds.

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“…4 In our case, according to radiotherapist we decided not to perform radiotherapy. Management of massive pelvic defects can be a challenging problem.…”

Section: Discussionmentioning

confidence: 85%

Paraplegia in a patient with Von Hippel Lindau syndrome: surgical and reconstructive treatment of Marjolin’s ulcer. A case report

et al. 2014

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Study design: Marjolin's ulcer is a squamous cell carcinoma that develops in posttraumatic scars and chronic wounds. Suspicion of such lesions should be raised in chronic wounds demonstrating characteristic changes. We have reported the peculiar phenomenon of malignant transformation of chronic pressure sores that occurred in a paraplegic patient. Objectives: The aim of this study was to cover the extensive defects by a last resort reconstructive option. Setting:

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Impact of Disturbed Wound Healing after Surgery on the Prognosis of Marjolin's Ulcer

Cited by 22 publications

References 13 publications

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs

Marjolin’s ulcer in chronic wounds – review of available literature

Paraplegia in a patient with Von Hippel Lindau syndrome: surgical and reconstructive treatment of Marjolin’s ulcer. A case report

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