Marital status is associated with survival of patients with astrocytoma

Xie, Junchao; Yang, Shuai; Liu, Xueyuan; Zhao, Yanxin

doi:10.1016/j.jocn.2018.07.005

Cited by 10 publications

(12 citation statements)

References 24 publications

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“…In an esophageal cancer study [23] of patients diagnosed from 1973 to 2013 Cox regression analysis suggested in, in comparison with the married groups, there were higher risks of death for the unmarried, divorced/separated, and widowed groups for all aspects. In another study of astrocytoma based on SEER, Xie et al [24] indicated that the OS and CSS of married patients tended to be the highest, while for other subgroups, divorced/separated or widowed patients had worse CSS. Furthermore, according to the subgroup analyses, there was no significant difference in the CSS between the single and married women.…”

Section: Discussionmentioning

confidence: 99%

Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database

2019

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Background: As the most malignant bone tumor globally, osteosarcoma has drawn increased attention. However, no studies have focused on the association between marital status and survival rate. The objectives of this study were to determine the association between marital and survival rate of osteosarcoma patients based on the SEER database. Material/Methods: We enrolled a total of 2725 osteosarcoma patients between 1973 and 2015, including 1184 married, 154 divorced/separated, 136 widowed, and 1251 never-married patients. Survival rate was determined based on the Kaplan-Meier method in different marital subgroups. Multivariate Cox regression analysis was performed to explore independent prognostic factors. Results: The 5-year overall survival (OS) and cancer-specific survival (CSS) rates of the married, separated/divorced, widowed, and never-married subjects were 45.93%, 41.39%, 19.08%, and 57.21% (OS), and 49.97%, 45.85%, 22.14%, and 60.69% (CSS), respectively. The survival outcome among subgroups exhibited a clear difference, with a log-rank test p-value <0.0001. Multivariate Cox regression showed that widowhood served as the independent prognostic factor for decreased OS rather than marriage (HR, 1.246; 95% CI, 1.011-1.536; p-value=0.039) and CSS (HR, 1.34; 95% CI, 1.07-1.68; p-value=0.01). Moreover, the OS and CSS in widowed patients were lower. Additionally, based on the propensity score matching (PSM) method, the prognosis of married patients was better than that of unmarried subjects. Conclusions: Marital status was correlated with the survival rate, meaning that married patients had higher survival than widowed subjects, who had worse prognoses of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database

2019

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“…Several other studies regarding HGG have studied several prognostic factors including age, gender, recurrent disease, tumor location, WHO grade, primary treatment, RT, and EOR. 28 45 46 47 48 49 50 51 52 Another study by Lee et al showed no association between bevacizumab use and thromboembolic events. 53 One study evaluated 4,407 patients via the NSQIP database who underwent resection of a malignant brain tumor between 2007 and 2012.…”

Section: Resultsmentioning

confidence: 98%

“…Multiple studies have evaluated glioma by including either LGG as a broad category or comparing LGG with HGG. 1 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Several studies evaluated the epidemiology of gliomas and demonstrated increased likelihood in Caucasians, older, or male patients, patients with prior smoking history, women with prior breast cancer treatment, and insured patients. 13 14 15 16 19 Plascak et al evaluated 24,230 glioma patients using the SEER database between 2000 and 2006; they showed a greater incidence of gliomas in countries with higher socioeconomic status, which suggested unequal distribution of diagnostic resources.…”

Section: Resultsmentioning

confidence: 99%

“…These studies have suggested that White race, younger age, more recent diagnosis, lower WHO grade or histology, marital status, better socioeconomic status, EOR, radiotherapy, radiochemotherapy, treatment at high-volume facilities, and tumor size positively impact patient prognosis. 1,4,16,17,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Missios et al evaluated 21,384 cases of glioma between 2005 and 2011 using the National Inpatient Sample (NIS) database and showed that perioperative complications were increased by greater age, coagulopathy, coronary artery disease, congestive heart failure, and smoking history. 37 Although these studies have had an impact by identifying consistent risk and prognostic factors, they are limited by aggregating glioma types, mostly as a limitation of lacking molecular data in nearly all multicenter databases.…”

Section: Low Grade Gliomamentioning

confidence: 99%

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Utility of Administrative Databases and Big Data on Understanding Glioma Treatment—A Systematic Review

Owens

Nguyen

Karsy

2022

Indian Journal of Neurosurgery

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Background Gliomas are a heterogeneous group of tumors where large multicenter clinical and genetic studies have become increasingly popular in their understanding. We reviewed and analyzed the findings from large databases in gliomas, seeking to understand clinically relevant information. Methods A systematic review was performed for gliomas studied using large administrative databases up to January 2020 (e.g., National Inpatient Sample [NIS], National Surgical Quality Improvement Program [NSQIP], and Surveillance, Epidemiology, and End Results Program [SEER], National Cancer Database [NCDB], and others). Results Out of 390 screened studies, 122 were analyzed. Studies included a wide range of gliomas including low- and high-grade gliomas. The SEER database (n = 83) was the most used database followed by NCDB (n = 28). The most common pathologies included glioblastoma multiforme (GBM) (n = 67), with the next category including mixes of grades II to IV glioma (n = 31). Common study themes involved evaluation of descriptive epidemiological trends, prognostic factors, comparison of different pathologies, and evaluation of outcome trends over time. Persistent health care disparities in patient outcomes were frequently seen depending on race, marital status, insurance status, hospital volume, and location, which did not change over time. Most studies showed improvement in survival because of advances in surgical and adjuvant treatments. Conclusions This study helps summarize the use of clinical administrative databases in gliomas research, informing on socioeconomic issues, surgical outcomes, and adjuvant treatments over time on a national level. Large databases allow for some study questions that would not be possible with single institution data; however, limitations remain in data curation, analysis, and reporting methods.

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“…A glioma is a tumour produced by glial cells and is the most common primary malignant tumour in the central nervous system, accounting for ~30% of the tumours in this region (1,2). Astrocytoma is one of the most aggressive gliomas, with a poor prognosis (3,4). Astrocytomas can be found in various parts of the central nervous system and are a common neuroepithelial tumour that can occur in individuals of all ages (5).…”

Section: Introductionmentioning

confidence: 99%

Advantages of gross total resection in patients with astrocytoma: A population‑based study

Mao

2020

Oncol Lett

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The present study aimed to investigate the association between surgical methods and survival outcomes in patients with astrocytoma. Patients diagnosed with astrocytoma between January 2004 and December 2015 were identified using the Surveillance, Epidemiology and End Results database. Kaplan-Meier curves and Cox regression were used to analyze the effects of surgical methods on overall survival (OS) and cancer-specific survival (CSS). Among 42,224 eligible patients with astrocytoma, 11,427 (27.1%) patients did not receive surgery, 7,661 (18.1%) received excisional biopsy (EB), 5,520 (13.1%) received a subtotal resection (STR), 6,037 (14.3%) received a gross resection (GR), 5,314 (12.6%) received a partial resection (PR) and 6,265 (14.8%) received a gross total resection (GTR). Patients who underwent GR had the longest survival time (17.00 months). However, over time, the proportion of patients who underwent STR or GR increased, whereas the proportion of patients who did not undergo surgery, PR or GTR decreased. Furthermore, surgical method was an independent prognostic factor for OS and CSS for the patients with astrocytoma. Multivariate Cox regression showed that GTR was associated with the more favorable OS [hazard ratio (HR), 0.80; 95% confidence interval (CI), 0.77-0.83; P<0.001] and CSS (HR, 0.80; 95% CI, 0.77-0.83; P<0.001) times compared with EB. Moreover, similar results were observed in subgroup analyses based on summary stage and grade. In the present study, it was demonstrated that GTR was one of the effective surgical methods for improved OS and CSS time in patients with astrocytoma. However, among the American astrocytoma population, the proportion of patients who underwent GTR decreased. It is necessary to further advocate for the efficacy of GTR.

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Marital status is associated with survival of patients with astrocytoma

Cited by 10 publications

References 24 publications

Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database

Marital Status and Survival in Osteosarcoma Patients: An Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database

Utility of Administrative Databases and Big Data on Understanding Glioma Treatment—A Systematic Review

Advantages of gross total resection in patients with astrocytoma: A population‑based study

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