Marital status and risk of Alzheimer’s disease

Helmer, Catherine; Damon, D.; Letenneur, Luc; Fabrigoule, Colette; Barberger‐Gateau, Pascale; Lafont, Sylviane; Fuhrer, Rebecca; Antonucci, Toni C.; Commenges, Daniel; Orgogozo, J. M.; Dartigues, J.-F.

doi:10.1212/wnl.53.9.1953

Cited by 158 publications

(116 citation statements)

References 16 publications

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“…In the PAQUID study, nevermarried older persons had a significantly increased risk of Alzheimer's disease, independent of education, wine consumption, and leisure activities (Helmer et al, 1999). This relationship might be partly explained by poorer food habits.…”

Section: Discussionmentioning

confidence: 94%

Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study

et al. 2005

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Section: Discussionmentioning

confidence: 94%

Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study

et al. 2005

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“…Another study that evaluated social and leisure activity data in elderly community residents from France reported that traveling, doing odd jobs, and knitting were associated with lower risk of incident dementia [65,66]. Community activities and gardening were also protective for incident dementia in China [17].…”

Section: Social and Intellectual Activitiesmentioning

confidence: 99%

Cognitive reserve: Implications for diagnosis and prevention of Alzheimer’s disease

Scarmeas

Stern

2004

Curr Neurol Neurosci Rep

203

132

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Epidemiologic evidence suggests that higher occupational attainment and education, as well as increased participation in intellectual, social, and physical aspects of daily life, are associated with slower cognitive decline in healthy elderly and may reduce the risk of incident Alzheimer's disease (AD). There is also evidence from structural and functional imaging studies that patients with such life experiences can tolerate more AD pathology before showing signs of clinical dementia. It has been hypothesized that such aspects of life experience may result in functionally more efficient cognitive networks and, therefore, provide a cognitive reserve that delays the onset of clinical manifestations of dementia. In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations.

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“…Marital status is a potential marker of mental status, lifestyle, and social and family support, and has a significant impact on the prognosis of patients with cardiovascular disease, cancer, or mental disorders 5, 6, 7. Using data from the US Surveillance, Epidemiology, and End Results (SEER) database, studies have determined that marital status is associated with overall and cancer‐specific survival in renal cancer, head and neck cancer, bladder cancer, and lung cancer 8, 9, 10, 11.…”

Section: Introductionmentioning

confidence: 99%

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

et al. 2018

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The relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan‐Meier test was conducted to compare the survival curves of different groups. Multivariate Cox regression was performed to evaluate overall survival (OS) and cause‐specific survival (CSS) in different groups. Subgroup analysis was applied according to demographics, typical education and income levels in the locale, and insurance status. A total of 30 767 eligible patients were included. The median OS values were 9, 7, 3, 9 months in married, divorced/separated, widowed, and single patients, respectively. After adjustment for other covariates, married patients had better OS and CSS than other patients had. In addition to marital status, demographic factors, disease progression factors, local educational level, and insurance status were also associated with survival in GBM. Furthermore, subgroup analyses revealed the protective effect of marriage in most of the comparisons. Notably, the protective effect of marriage becomes more and more apparent as time goes on. The advantageous effect of marriage on GBM survival is especially prominent in patients who are male, older than 60 years of age, White, or living in middle‐income counties. In conclusion, marital status is an independent prognostic factor for GBM.

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Marital status and risk of Alzheimer’s disease

Abstract: We confirmed an association between marital status and AD, with an excess risk observed among never-married individuals. This association may provide clues about the pathogenesis of AD.

Cited by 158 publications

References 16 publications

Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study

Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study

Cognitive reserve: Implications for diagnosis and prevention of Alzheimer’s disease

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

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