Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Barbosa, Ana Isabel; Coutinho, Ana Joyce; Lima, Sofia A. Costa; Reis, Salette

doi:10.3390/md17120654

Cited by 105 publications

(54 citation statements)

References 149 publications

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“…These molecules can produce a spontaneous self-assembly or complexation with therapeutic agents. Polysaccharides such as chitosan, alginate, and pectin are among a few of the studied nanocarriers capable of forming self-assemblies with a wide range of molecules and therapeutic agents [12,13]. Pectin is a highly suitable molecule for drug delivery applications [14][15][16][17] due to its superior water solubility.…”

Section: Introductionmentioning

confidence: 99%

Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

et al. 2020

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Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanocomplexes were characterized by particle size and morphology (DLS, TEM, and SEM), FT-IR spectroscopy, and zeta potential measurements. Additionally, MPT-NCs were capable of encapsulating anticancer drugs (5-fluorouracil, gemcitabine, and irinotecan) through tannic acid binding. The in vitro bioactivity of these drug MPT-NCs were evaluated in pancreatic cancer adenocarcinoma (PDAC) cell lines (HPAF-II and PANC-1). A dose-dependent internalization of nanocomplexes was evident from microscopy and flow cytometry analysis. Both proliferation and colony formation assays indicated the anticancer potential of pectin drug nanocomplexes against PDAC cells compared to that of free drug treatments. Together, the pectin-based nanocomplexes could be a reliable and efficient drug delivery strategy for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

et al. 2020

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“…It has also been used as a drug carrier, especially for anti-cancer treatments and anti-biotics. Additionally, fucoidans have been shown to improve drug bioavailability and efficacy in pharmaceutical formulations, including in nanoparticles, liposomes, microparticles, and semisolid formulations [28, 149,150]. Table 1 summarizes some of the recent and uncommon fucoidans applications based on in-vitro or in-vivo studies, in addition to biogenic resources and physicochemical features.…”

Section: Recent Uncommon Applicationsmentioning

confidence: 99%

Fucoidans: Downstream Processes and Recent Applications

Zayed

Ulber

2020

Marine Drugs

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Fucoidans are multifunctional marine macromolecules that are subjected to numerous and various downstream processes during their production. These processes were considered the most important abiotic factors affecting fucoidan chemical skeletons, quality, physicochemical properties, biological properties and industrial applications. Since a universal protocol for fucoidans production has not been established yet, all the currently used processes were presented and justified. The current article complements our previous articles in the fucoidans field, provides an updated overview regarding the different downstream processes, including pre-treatment, extraction, purification and enzymatic modification processes, and shows the recent non-traditional applications of fucoidans in relation to their characters. of 22reproductive, immune and cell-to-cell communicative roles [23]. As recommended by the International Union of Pure and Applied Chemistry (IUPAC), fucoidans is a general term used to describe sulfated L-fucose-based polymers including sulfated fucans cited by the Swedish scholar Kylin, as well as other fucose-rich sulfated heteropolysaccharides [23,28]. Their chemical structures, in terms of monomeric composition and branching, are quite simple in marine invertebrates compared to their analogues in brown algae [13,29].Hundreds of articles have thoroughly discussed and reviewed the biological, pharmacological and pharmaceutical applications of fucoidans [30][31][32][33], including nanomedicine, [34] which has made it a hot topic in the last few decades [35][36][37]. All these studies tried to investigate fucoidans molecular mechanisms in relation to their chemical structure and physicochemical properties. Therefore, different hypotheses were suggested for each activity, such as anti-tumor [31,[38][39][40], anti-coagulant [41,42], anti-viral [43,44] and anti-inflammatory activity [45,46]. These investigations revealed that various factors are relevant, such as molecular weight, sulfation pattern, sulfate content and monomeric composition [47][48][49]. For example, different fractions were produced with different physicochemical properties in our previous experiments; sulfation pattern and sulfate content were highly related to anti-viral and cytotoxic activities against HSV-1 and Caco-2 cell lines, respectively, while molecular weight and sugar composition were potential factors in anti-coagulation activity [41,50]. In addition, degree of purity was reported as an influential factor [32], where co-extracted contaminants (e.g., phlorotannins or polyphenols) could lead to significant interference in anti-oxidant activity and, consequently, cosmetic applications [51,52].Therefore, several key production challenges regarding fucoidans were discussed in our last review article in order to obtain a product that follows the universal good manufactured practice (GMP) guidelines. The article discussed sources of heterogeneity in extracted fucoidans, including the different biotic (e.g., biogenic, geographical and seas...

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“…As alginic acid and its derivatives have good stability, solubility and viscosity and are safe, they are often used as excipients for food or pharmaceutical preparations to achieve thickening, stability and emulsification [ 13 ]. However, recent studies have shown that alginic acid and its derivatives also have good biocompatibility, antioxidant activity and anti-inflammatory activity [ 14 , 15 , 16 , 17 ]. At present, they are mostly commonly applied in cosmetics, and there are various anti-wrinkle, moisturizing and anti-ultraviolet products available [ 6 ].…”

Section: Alginic Acid and Its Derivativesmentioning

confidence: 99%

“…It is resistant to acid, but decarboxylation occurs when it is reacted with concentrated hydrochloric acid. It exhibits selective adsorption effects towards metal ions [ 16 ], in particular, Fe (Ⅱ) ions [ 18 , 19 ].…”

Section: Alginic Acid and Its Derivativesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Cited by 105 publications

References 149 publications

Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

Fucoidans: Downstream Processes and Recent Applications

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

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