Marine natural products

Abstract

This review covers the literature published in 2008 for marine natural products, with 829 citations (613 for the period January to December 2008) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1065 for 2008), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis

“…[1][2][3] Actinomycetes in particular Streptomyces species still represent almost inexhaustible source of new compounds with antibiotic, antifungal and other important biological activities. 4 Polyketides a highly diverse group of natural products are currently represented with over 10 000 members so far identified.…”

Halogenated Organic Molecules of Rhodomelaceae Origin: Chemistry and Biology

“…A complete data set which is suitable for determining both the structure and the absolute configuration of the entire molecule was obtained by combining results from two different crystals. 29 As for caespitol (15), it was originally reported as a chamigrane sesquiterpene as determined by spectroscopic analysis 33 but the structure was subsequently revised to a bisabolane sesquiterpene 15 based on the results of X-ray studies of isocaespitol (23), a coexisting sesquiterpene in the same species of L. caespitosa, as well as by chemical correlation between the two isomers. 34 4.2.2.…”

“…21 A series of timely reviews entitled "Marine natural products" provided comprehensive surveys of all natural products that were isolated and reported from marine resources annually. 22,23 In addition to the above listed reviews, a book chapter entitled "Constituents of Laurencia" appeared in 1983 24 and provided a consolidated review covering all types of compounds, both halogenated and nonhalogenated, reported from species of the genus Laurencia, the most heavily studied algal genus within the family Rhodomelaceae. However, none of the above-mentioned reviews provided a full-aspect and in-depth view on the array of halogenated organic molecules from the algal family Rhodomelaceae.…”

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

“…72 However, the isolation of several of these metabolites from many sources other than sponges within the order Verongida 17,73 challenged previous assumptions on the actual origin of these metabolites. 17 The MeOH extract of the sponge Verongula gigantea yielded the known (Figure 17) 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-dimethylethanammonium (131) and 2,6-dibromo-4-(2-(trimethylammonium)ethyl)phenol (132). 58 Further investigation on the metabolites of the marine sponge Aplysina caissara led to the isolation of the new agelocaissarines A1 (133, Figure 17), A2 (134, Figure 17), B1 (135, Figure 17), B2 (136, Figure 17) and caissarine C (137, Figure 17), together with the known 11-hydroxyaerothionin (13, Figure 2) and fistularin-3 (14, Figure 2).…”