Marine natural products: metabolites of marine invertebrates

Faulkner, D. John

doi:10.1039/np9840100551

Cited by 325 publications

(160 citation statements)

References 205 publications

(280 reference statements)

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“…In general, information on the chemical composition of marine invertebrates is restricted to taxa with economic importance, such as some species of crustaceans and molluscs, particularly species that are useful as food or feed (e.g., Karakoltsidis et al, 1995;Orban et al, 2002;Sriket et al, 2007;Nurnadia et al, 2011;Sánchez-Camargo et al, 2011). Invertebrates have also been studied in the context of bioprospection of natural products, a search for bioactive molecules that can be used in pharmaceuticals and in potential biotechnological applications (e.g., Faulkner, 1984;Haygood et al, 1999;Haefner, 2003;Newman & Cragg, 2004;Leal et al, 2012;Yang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Diniz

Barbarino

Oiano-Neto

et al. 2014

lajar

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ABSTRACT. The chemical profiles of Desmapsamma anchorata, Hymeniacidon heliophila (Porifera), Bunodosoma caissarum, Renilla muelleri (Cnidaria), Aplysia brasiliana, Eledone massyae, Isognomon bicolor (Mollusca), Echinaster brasiliensis, Echinometra lucunter, Holothuria grisea, Lytechinus variegatus (Echinodermata), and Phallusia nigra (Chordata) were determined. Hydrosoluble protein was the most abundant class of substances for all species, except for the ascidian Phallusia nigra, in which the carbohydrate content was higher. The percentages of hydrosoluble protein (dry weight, dw) varied widely among the invertebrates, ranging from 5.88% (R. muelleri) to 47.6% (Eledone massyae) of the dw .The carbohydrate content fluctuated from 1.3% (R. muelleri) to 18.4% (Aplysia brasiliana) of the dw. For most of the species, lipid was the second most abundant class of substances, varying from 2.8% (R. muelleri) to 25.3% (Echinaster brasiliensis) of the dw. Wide variations were also found for the invertebrates nitrogen content, with the lowest value recorded in the cnidarian R. muelleri (2.02% of the dw) and the highest in the molluscan E. massyae (12.7% of the dw). The phosphorus content of the dw varyed from 0.24% (R. muelleri) to 1.16% (E. massyae). The amino acid composition varied largely among the species, but for most of the species glycine, arginine, glutamic acid, and aspartic acid were the most abundant amino acids, with histidine and tyrosine among the less abundant amino acids. The actual content of total protein in the samples was calculated by the sum of amino acid residues, establishing dw values that fluctuated from 11.1% (R. muelleri) to 66.7% (E. massyae). The proteinaceous nitrogen content was high in all species, with an average value of 97.3% of the total nitrogen. From data of total amino acid residues and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors ranged from 5.10 to 6.15, with an overall average of 5.45. The use of the specific nitrogen-to-protein conversion factors established here is recommended, since it would yield more accurate determinations of total protein in the species tested in this study. Keywords: nitrogen-to-protein conversion factors, total protein, amino acid composition, lipid, carbohydrate, tropical Atlantic. Composición proximal de invertebrados marinos de aguas costeras tropicales,con énfasis en la relación entre los contenidos de nitrógeno y proteína RESUMEN. Se determinaron los perfiles químicos de Desmapsamma anchorata, Hymeniacidon heliophila (Porifera), Bunodosoma caissarum, Renilla muelleri (Cnidaria), Aplysia brasiliana, Eledone massyae, Isognomon bicolor (Mollusca), Echinaster brasiliensis, Echinometra lucunter, Holothuria grisea, Lytechinus variegatus (Echinodermata), y Phallusia nigra (Chordata). La clase más abundante de sustancias para todas las especies fueron las proteínas hidrosolubles, excepto para la ascidia Phallusia nigra, en la que el contenido de carbohidratos fue ...

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Section: Introductionmentioning

confidence: 99%

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Diniz

Barbarino

Oiano-Neto

et al. 2014

lajar

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“…Infrared spectra were obtained as thin films on NaCl plates using a Thermo Electron IR100 series instrument and are reported in terms of frequency of absorption (cm -1 ). 1 cooled to 0 °C and quenched with water (2 mL), saturated aqueous sodium bicarbonate (2 mL), and saturated aqueous sodium metabisulfite (2 mL). The mixture was stirred for 5 min at 0 °C, allowed to warm to room temperature and stirring continued for 15 min.…”

Section: Instrumentationmentioning

confidence: 99%

“…1 These compounds are presumed to have no direct relationship to the organism's normal function, although many scientists believe these metabolites may play a significant role in the life of the producing species, despite lack of any evidence related to actual function. 2 An important source of marine secondary metabolites are sponges.…”

Section: Introduction To Marine Secondary Metabolitesmentioning

confidence: 99%

Total Synthesis of (±)‐Haliclonacyclamine C

Smith

Sulikowski

2010

Angew Chem Int Ed

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“…Soft corals are an unusually productive source of chemically interesting and biologically significant secondary metabolites [1,2]. The vast majority of identified metabolites from soft corals are terpenoids, among which the cembranoid diterpenes are dominating [1].…”

Section: Introductionmentioning

confidence: 99%

“…The vast majority of identified metabolites from soft corals are terpenoids, among which the cembranoid diterpenes are dominating [1]. Chemical investigation of soft corals of the genus Dendronephthya collected from various locations led to the isolation of a variety of compounds, most of them with steroid skeletons [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Dendrophen, a Novel Glycyrrhetyl Amino Acid from Dendronephthya hemprichi

Shaaban

Abd‐Alla

et al. 2011

Zeitschrift Für Naturforschung B

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Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β -acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.

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Marine natural products: metabolites of marine invertebrates

Cited by 325 publications

References 205 publications

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Total Synthesis of (±)‐Haliclonacyclamine C

Dendrophen, a Novel Glycyrrhetyl Amino Acid from Dendronephthya hemprichi

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