Marine Natural Products: A New Wave of Drugs?

Montaser, Rana; Luesch, Hendrik

doi:10.4155/fmc.11.118

Cited by 371 publications

(299 citation statements)

References 103 publications

(120 reference statements)

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“…Recently, several new medications based on substances from these marine organisms have undergone clinical and preclinical trials [1]. Natural ingredients obtained from the ocean, especially from marine invertebrates, have become important sources of new compounds [2][3][4]. Moreover, many studies have screened the anti-inflammatory properties and activities of marine compounds for the treatment of chronic illnesses [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti

et al. 2014

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To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti

et al. 2014

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“…They contain an intangible number of proteases and inhibitors, used for feeding and self-defense system against predators [19]- [22]. Many compounds with therapeutic potentialities have been isolated from these organisms, although most of them are poorly studied [17]. Cuban coasts have a remarkable variety of marine invertebrates, which allows screening of biological activity straight from natural sources as a first step to identify new molecules with potential properties such as toxins, antimicrobial peptides, proteases and inhibitors [23]- [28].…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, natural inhibitors have shown good properties to be used in biological systems, as they have mostly high stability at physiological conditions and low toxicity. On the other hand, natural sources are an infinite stock of bioactive molecules and structures, as a result of several millions years of evolution [17]- [19].…”

Section: Introductionmentioning

confidence: 99%

Screening of Protease Inhibitory Activity in Aqueous Extracts of Marine Invertebrates from Cuban Coast

González¹,

Sánchez²,

Rojas³

et al. 2016

AJAC

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Protease inhibitors have been isolated from many variable sources; however, the need to identify and characterize new molecules has increased with the discovery of new therapeutic targets and the lack of specificity of already identified compounds with inhibitory activity. The goal of this work was to search for inhibitory activity against four proteolytic enzymes already recognized as therapeutic targets: human neutrophil elastase, dipeptidyl peptidase IV, subtilisin from Bacillus licheniformis and cathepsin K in selected marine invertebrates from the Caribbean Sea. A systematic screening was carried out with selected aqueous extracts belonging to 20 species from seven different phyla: Annelida, Bryozoa, Chordata, Cnidaria, Equinodermata, Mollusca and Porifera, all collected at the coast of Havana (Cuba). All extracts showing initial inhibitory activity were characterized in terms of IC50 values and specific inhibitory activity (SIA). Model enzymes were used in the case of human neutrophil elastase (porcine pancreatic elastase) and cathepsin K (papain) for the screening and all positive results were confirmed by testing toward the therapeutic targets. Ten extracts were identified showing inhibitory activity against human neutrophil elastase, for which the most promising values were obtained for Nerita peloronta. Only one extract, Bunodosoma granulifera, showed inhibitory activity against dipeptidyl peptidase IV with rather poor values of IC50 and SIA. Seven extracts showed inhibitory activity against B. licheniformis subtilisin with very good IC50 and SIA values for Lissodendorix isodyctialis, Cenchritis muricatus, and N. peloronta. Finally, eight extracts were positive for cathepsin K with almost similar parameters values among them. All these results confirmed the richness and potential of the marine invertebrate's fauna and indicated new promising sources for the identification of natural compounds with potential application in therapeutics.

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“…Marine that biotechnology including marine sources may be used as pharmaceutical drugs as it is enriched with active ingredients that can contribute to design and develop new potential pharmaceutical agents (Montaser and Luesch, 2011). Marine algae are considered as a source of bioactive agents that have a variety of biological activities (Cox et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Sayed¹,

Sadek²,

Soliman³

et al. 2016

AJTCAM

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Background: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis, in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments. Materials and Methods: In vitro, AFP was analyzed for its chemical constituents screening, amino acid, proteinase inhibitory activity, HRBC membrane stabilization activity, free radical scavenging activity, total antioxidant potency, nitric oxide radical scavenging power. In vivo, Organization for Economic Co-operation and Development (OECD) toxicity test was performed to test the safety of AFP on rats.Results: The present findings revealed that AFP and AFG can be considered as inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD guideline. Conclusion: AFP and AFG may have the potency to become the therapeutic candidate for OA disease as it prevents the key causes of OA initiation.

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Marine Natural Products: A New Wave of Drugs?

Cited by 371 publications

References 103 publications

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti

Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti

Screening of Protease Inhibitory Activity in Aqueous Extracts of Marine Invertebrates from Cuban Coast

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

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