Marine Microbial Diversity as a Source of Bioactive Natural Products

Stien, Didier

doi:10.3390/md18040215

Cited by 21 publications

(15 citation statements)

References 20 publications

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“…Interest in the oceans has grown in recent decades due to the enlargement of discovery in quantity and diversity of marine products with interesting biological/pharmacological activities [ 29 , 30 , 31 ]. Over the past fifty years, progressive improvements have been made in the exploration of new marine habitats, leading to the isolation of thousands of unique marine natural products [ 30 ] for industrial development, such as pharmaceuticals, food ingredients, cosmetics, drug delivery systems (DDS) and industrial enzymes [ 31 , 32 , 33 ]. Species such as algae, sponges and corals are in constant competition because they are at high risk of predation, so these species have developed chemical defense mechanisms based on the synthesis of toxic secondary metabolites [ 34 ].…”

Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.

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Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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“…Four verrucosidin derivatives, penicyrone (52), norpenicyrone (53), methyl norpenicyrone (54), and methyl penicyrone (55) were isolated from the hydrothermal vent sulfurderived fungus Penicillium sp. Y-50-10 (Kueishantao, Taiwan, the East China Sea).…”

Section: Antifungal Activitymentioning

confidence: 99%

“…As a result, the search for leader antitumor molecules among the metabolites of marine fungi is one of the stable modern trends in chemistry of natural compounds [ 55 , 56 ].…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

2021

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Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020.

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“…Marine ecosystems, the world's main reservoir of biodiversity and a relevant source of marine natural products (MNPs), are providing a large number of compounds with antitumor, antibacterial, antiviral and anti-inflammatory properties, among others [1][2][3][4][5]. Specifically, some marine organisms such as algae and animals are a source of products with anticancer activity which have been tested as a new or adjuvant treatment [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxidant Compounds for Colon Cancer Therapy: A Preliminary In Vitro Study

Cabeza

Peña

Martínez

et al. 2021

Biology

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Recently, invertebrate marine species have been investigated for the presence of natural products with antitumor activity. We analyzed the invertebrate Anemonia sulcata with (W) and without (W/O) the presence of its microalgal symbiont Symbiodinium as a source of bioactive compounds that may be applied in the therapy and/or prevention of colorectal cancer (CRC). Animals were mechanically homogenized and subjected to ethanolic extraction. The proximate composition and fatty acid profile were determined. In addition, an in vitro digestion was performed to study the potentially dialyzable fraction. The antioxidant and antitumor activity of the samples and the digestion products were analyzed in CRC cells in vitro. Our results show a high concentration of polyunsaturated fatty acid in the anemone and a great antioxidant capacity, which demonstrated the ability to prevent cell death and a high antitumor activity of the crude homogenates against CRC cells and multicellular tumor spheroids, especially W/O symbiont. These preliminary results support that Anemonia sulcata could be a source of bioactive compounds with antioxidant and antitumor potential against CRC and that the absence of its symbiont may enhance these properties. Further studies will be necessary to define the bioactive compounds of Anemonia sulcata and their mechanisms of action.

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Marine Microbial Diversity as a Source of Bioactive Natural Products

Abstract: Some 3 [...]

Cited by 21 publications

References 20 publications

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxidant Compounds for Colon Cancer Therapy: A Preliminary In Vitro Study

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