Marine-Derived Aspergillus Species as a Source of Bioactive Secondary Metabolites

Lee, Yoon Mi; Kim, Min Jeong; Li, Huayue; Zhang, Ping; Bao, Baoquan; Lee, Ka Jeong; Jung, Jee H.

doi:10.1007/s10126-013-9506-3

Cited by 88 publications

(65 citation statements)

References 89 publications

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“…In recent years, an increasing number of bis-naphtho-γ-pyrones have been isolated from endophytic fungi [3,10,20] and marine-derived fungi [7,16,23]. These fungi could be the rich sources of biologically active metabolites that are indispensable for medicinal and agricultural applications [1,[63][64][65][66]. In most cases, biological activities, structure-activity relationships, and mode of action of bis-naphtho-γ-pyrones have been only primarily investigated and need to be studied in detail.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Tian

Sun

et al. 2014

Molecules

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Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Tian

Sun

et al. 2014

Molecules

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confidence: 99%

Butyrolactones from the Fermentation Products of the Endophytic Fungus Aspergillus versicolor

et al. 2016

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Two new butyrolactones, versicolactones E-F (1 and 2), along with three known butyrolactones (3)(4)(5), were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1-5 were evaluated. Compounds 1-5 showed modest anti-TMV activities with inhibition rates of 14.6-18.8%.Aspergillus versicolor is an ubiquitous fungus species commonly isolated from soil, plant debris, marine environments, and indoor air environments >1, 2@. Many metabolites produced by A. versicolor exhibit antibacterial, fungicidal, insecticidal, and cytotoxic properties >3-5@.Butyrolactones are a class of lactones with a four-carbon heterocyclic ring structure, and these compounds are found mainly as metabolites from fungi and higher plants in nature >6@. These compounds appeal to medicinal chemists because of their pronounced pharmacological effects, including antibacterial >7, 8@, cytotoxic >9, 10@, anti-inflammatory >11, 12@, and antiviral >8, 13@ activities.Motivated by a search for new bioactive metabolites from the fermentation products of microbes, the endophytic fungus Aspergillus versicolor was isolated from the rhizome of Paris polyphylla var. yunnanensis, collected in Kunming, Yunnan, P. R. China, and the chemical constituents of its fermentation products were investigated. As a result, two new (1 and 2) and three known butyrolactones (3-5) were isolated. This paper deals with the isolation and structural characterization of these compounds and the anti-tobacco mosaic virus (anti-TMV) activity of compounds 1-5.

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“…Aspergilus, the most abundant fungi associated with U. intestinalis, is well known as a good source of antibiotic. Natural products produced by marine origin Aspergillus such as stephacidin B and plinabulin showed antitumor activity (Lee et al, 2013). In addition, the crude extract of Aspergillus terreus had antibacterial activity against fish pathogen (Volkmann & Gorbushina, 2006).…”

Section: Shared Species Phylogenetic Tree Of Fungal Communities Assocmentioning

confidence: 99%

Fungal Community Structure of Macroalga Ulva Intestinalis Revealed by Miseq Sequencing

Agusman

Feng

2017

Squalen Bull. Marine Fisheries Postharvest Biotech.

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Since algae are well known as the host of fungi, the information about total fungal community associated with alga is needed to give the initial data that is useful for natural product discovery. The study on total fungal community associated with marine macroalga U. intestinalis from Xiamen-China was carried out using MiSeq, a powerful platform for microbial ecology studies. Metagenomics DNA was isolated from surfaces of the U. intestinalis thallus and rocks colonized by this alga and 18S ribosomal RNA region was sequenced using MiSeq Illumina to yield 81360 sequences from 162720 reads, which average read length is 245.61 bp. The sequences were assigned to operational taxonomic units (OTUs), where 101 genera represent 5 phyla, 17 classes and 64 families of fungal. Ascomycota was the highest abundance share of fungal community at phylum level. Meanwhile Aspergillus, Blastobotrys, Alternaria, Knufia, and Fusarium were some of dominant genera found associated with U. intestinalis which have been reported as the promising source of natural products. By using MiSeq platform, this study revealed the total community structure of algicolous fungi associated with U. intestinalis.

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Marine-Derived Aspergillus Species as a Source of Bioactive Secondary Metabolites

Cited by 88 publications

References 89 publications

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Butyrolactones from the Fermentation Products of the Endophytic Fungus Aspergillus versicolor

Fungal Community Structure of Macroalga Ulva Intestinalis Revealed by Miseq Sequencing

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