Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Abstract

Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.

Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection

“…Bis-naphtho-γ-pyrones have a broad range of biological activities, such as inhibition of adenosine triphosphate synthesis in mitochondria, cell proliferation inhibition, triacylglycerol synthesis inhibition, and antimicrobial activity. 29 Bis-naphtho-γ-pyrones are active against various bacteria, such as S. aureus , E. coli , and M. tuberculosis , with MIC values ranging from 2 μg/mL to 50 μg/mL. 29 Inhibition of adenosine triphosphate synthesis can explain the activity of bis-naphtho-γ-pyrone against stationary phase B. burgdorferi .…”

“…29 Bis-naphtho-γ-pyrones are active against various bacteria, such as S. aureus , E. coli , and M. tuberculosis , with MIC values ranging from 2 μg/mL to 50 μg/mL. 29 Inhibition of adenosine triphosphate synthesis can explain the activity of bis-naphtho-γ-pyrone against stationary phase B. burgdorferi . Cephalochromin has been shown to inhibit fatty acid biosynthesis.…”

Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim

“…With the increased use of natural product-based cancer chemotherapy, exploring the cytotoxic activity of phytochemicals for anticancer drug design has gained extensive attention worldwide [1]. Juglans mandshurica Maxim is a well-known member of the Juglandaceae family which is widely distributed throughout urban and rural areas in northeast China [2][3][4].…”

New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity

“…Moreover, dimeric naphthopyrones have a broad-range of biological activities such as cytotoxic, antitumour and antimicrobial properties. Among eight known polyketides 2-9, isoaurasperone A (2), fonsecinone A (3) and asperpyrone (7) showed antimicrobial activities according to the literature (Lu et al 2014).…”