Marine Collagen: Promising Biomaterial in Delivery of Therapeutics for Cancer Therapy

Ali, Md Kaisar; Mir, Sajjad Husain; Parvez, Rozeena

doi:10.1007/978-981-16-4787-1_8

Cited by 3 publications

(1 citation statement)

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“…In this scenario, a valid response to the ever-growing demand for collagen could come from marine sources, as they have no limitations in use for any religion and there are no reports of possible transmissible diseases from them [ 9 ]. Marine collagen is, in fact, a promising tool for wide-ranging biomedical applications, including scaffolds in tissue engineering and drug delivery systems [ 8 , 10 ]. Currently, marine collagen is mainly extracted from fish-processing industry by-products and bycatch [ 9 ]; however, many more remarkable sources can be found among marine invertebrates such as jellyfish, mollusks, soft corals, echinoderms, and sponges.…”

Section: Introductionmentioning

confidence: 99%

2D Collagen Membranes from Marine Demosponge Chondrosia reniformis (Nardo, 1847) for Skin-Regenerative Medicine Applications: An In Vitro Evaluation

Tassara,

Oliveri,

Vezzulli

et al. 2023

Marine Drugs

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Research in tissue engineering and regenerative medicine has an ever-increasing need for innovative biomaterials suitable for the production of wound-dressing devices and artificial skin-like substitutes. Marine collagen is one of the most promising biomaterials for the production of such devices. In this study, for the first time, 2D collagen membranes (2D-CMs) created from the extracellular matrix extract of the marine demosponge Chondrosia reniformis have been evaluated in vitro as possible tools for wound healing. Fibrillar collagen was extracted from a pool of fresh animals and used for the creation of 2D-CMs, in which permeability to water, proteins, and bacteria, and cellular response in the L929 fibroblast cell line were evaluated. The biodegradability of the 2D-CMs was also assessed by following their degradation in PBS and collagenase solutions for up to 21 days. Results showed that C. reniformis-derived membranes avoided liquid and protein loss in the regeneration region and also functioned as a strong barrier against bacteria infiltration into a wound. Gene expression analyses on fibroblasts stated that their interaction with 2D-CMs is able to improve fibronectin production without interfering with the regular extracellular matrix remodeling processes. These findings, combined with the high extraction yield of fibrillar collagen obtained from C. reniformis with a solvent-free approach, underline how important further studies on the aquaculture of this sponge could be for the sustainable production and biotechnological exploitation of this potentially promising and peculiar biopolymer of marine origin.

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