Marine Algae Polysaccharides as Basis for Wound Dressings, Drug Delivery, and Tissue Engineering: A Review

Abstract

<jats:p>The present review considers the physicochemical and biological properties of polysaccharides (PS) from brown, red, and green algae (alginates, fucoidans, carrageenans, and ulvans) used in the latest technologies of regenerative medicine (tissue engineering, modulation of the drug delivery system, and the design of wound dressing materials). Information on various types of modern biodegradable and biocompatible PS-based wound dressings (membranes, foams, hydrogels, nanofibers, and sponges) is provided; the results of experimental and clinical trials of some dressing materials in the treatment of wounds of various origins are analyzed. Special attention is paid to the ability of PS to form hydrogels, as hydrogel dressings meet the basic requirements set out for a perfect wound dressing. The current trends in the development of new-generation PS-based materials for designing drug delivery systems and various tissue-engineering scaffolds, which makes it possible to create human-specific tissues and develop target-oriented and personalized regenerative medicine products, are also discussed.</jats:p>

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

“…In addition, considering that the zeta potential is a parameter related with the non-colloidal stability, the highly negative values observed in here (−36 mV) confirmed the shelftime of hybrid nanoemulsion (Honary and Zahir, 2013). In fact, ALG is the most successful biopolymer used as a carrier, absorption enhancer or adjuvant for DDS (Guo et al, 2020;Kuznetsova et al, 2020), as well as the polymer counterpart of organic-organic DDS (Ribeiro et al, 2017a;Siepmann et al, 2019).…”

Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials

“…Such requirements are fulfilled by alginates, marine-originated [24], biodegradable [25][26][27][28][29] biopolymers applied as a basis for drug delivery, wound dressings, and tissue engineering [30][31][32][33][34].…”

“…Such requirements are fulfilled by alginates, marine-originated [ 24 ], biodegradable [ 25 , 26 , 27 , 28 , 29 ] biopolymers applied as a basis for drug delivery, wound dressings, and tissue engineering [ 30 , 31 , 32 , 33 , 34 ]. The strong affinity of alginates to metal cations allows for their application as antibacterial hybrids (e.g., [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]), and also for the removal of heavy metal salts, e.g., copper, lead, and mercury (e.g., [ 45 , 46 , 47 , 48 , 49 , 50 ]).…”

Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

“…Among various polysaccharides from red algae, ϰ-carrageenan has certainly been studied best of all for the purpose of the development of hydrogel-based wound dressings (as the most common type of wound dressing). In addition to biocompatibility, this biopolymer type exhibits pronounced hemostasiological and immunomodulatory properties necessary for healing [ 135 , 140 , 141 ].…”