Marine Algae-PLA composites as de novo alternative to porcine derived collagen membranes

Sayın, Selin; Kohlhaas, Theresa; Veziroglu, Salih; Okudan, Emine Şükran; Naz, Mehmet; Schröder, Stefan; Saygılı, Eyüp İlker; Açil, Yahya; Faupel, Franz; Wiltfang, Jens; Aktas, Oral Cenk; Gülses, Aydın

doi:10.1016/j.mtchem.2020.100276

Cited by 16 publications

(11 citation statements)

References 36 publications

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“…Both neat PLA ( Figure S1 ) and SVP-PLA patches exhibit a similar morphology composed of macroscale pores and microscale pin-lock type defects ( Figure 2 b). While the pore size of samples ranges from 250 µm to 400 μm, the size of pin-locks is around 30–40 µm [ 26 ]. On the other hand, on porous SVP-PLA composite patches, brownish residuals were also detected, which were not present on neat PLA.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to its proven bioactivity against bacteria, viruses, and other pathogens, the proliferative effect of S. vulgare on some cell types has been also reported by several researchers [ 24 , 25 ]. Recently, it has been proclaimed that the S. vulgare -PLA composites could induce fibroblast proliferation and might be a feasible option in clinical practice such as guided tissue regeneration, connective tissue augmentation, and wound regeneration [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

et al. 2021

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Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs’ adhesion and proliferation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

et al. 2021

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“…Macro-and microalgae are the latest sources of macromolecules and their alternative derivatives, such as carotenoid molecules found in the Chlorophyceae family, which includes microalgae Dunaliella, Chlorella, Muriellopsis, Haematococcus, and Chlamydomonas spp. (Berthon et al, 2017;Sayin et al, 2020;El-Chaghaby and Rashad, 2021). Furthermore, cyanobacteria also contain phycobiliproteins, accounting for 40% of these phycobiliproteins' overall dissolved protein content (El-Chaghaby and Rashad, 2021).…”

Section: Introductionmentioning

confidence: 99%

Algal-derived macromolecules and their composites: From synthetic biology to biomedical applications in bone and cardiovascular tissue engineering

Mayulu

Taslim²,

Hardinsyah³

et al. 2023

F1000Res

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Algae have shown numerous advantages as biofunctional and bioactive material sources. The development of biosynthetic or synthetic materials has enabled algal-derived macromolecules and their derivatives to be used in biomedical applications. This review examines and analyzes the most recent developments in the production of biomaterials from algal-derived macromolecules and their composites and their potential applications in bone and cardiovascular tissue engineering. Several macromolecules derived from algal polysaccharides, including sulfated polysaccharides, fucoidans, and fucans, have been developed for cartilage, intervertebral disc, bone, and skeletal muscle transplants because of their stable structures. Alginates, fucoidans, chitin, porphyrin, and other algal polysaccharide derivatives have been investigated for engineering blood vessels, heart valves, and even the liver. One advantage of algal-derived macromolecules and composites is their safe immunity properties. This review also highlights cutting-edge developments in applying algal-derived macromolecules with a broader biomedical scope to encourage in-depth research into their potential as biomaterial scaffolds in medical applications.

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“…Membrane separation process is one of the most effective techniques to solve the water issues and has been widely deployed in various fields such as chemical engineering, food engineering and pharmaceutical industry as well. − Up to now, the most membranes were prepared using polymeric materials such as polyamide (PA), polyvinylidene fluoride (PVDF), poly(ether sulfone) (PES), and cellulose acetate fiber (CA), whose features include easy processing, low cost, and excellent separation. − Nevertheless, because of their poor biodegradability, waste membranes always cause secondary environmental problems, which are increasingly taken into account and researched. − Ceramic materials were believed as an alternative that was easily regenerated at a high temperature. However, the high cost of ceramic materials hampers the wide application of ceramic membranes. , Most recently, biodegradable polymers have attracted lots of attention since they could be degradable with certain specific microorganisms or proteins while quite stable under service conditions. − PLA is such a kind of biodegradable polymeric materials that has been widely deployed in a wide range of medical applications. ,− Because PLA contains plenty of hydrophobic functional groups such as methyl groups and ester groups, it shows strong hydrophobic property . This always leads to serious fouling when applied as separation membranes. , Several attempts have gone into reducing the hydrophobicity of PLA nanofiber membranes and the membrane fouling through tailoring the surface roughness, − for example, introducing hydrophilic functional groups by incorporating TiO 2 nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Development of Hydrophilic Polylactic Acid Hollow-Fiber Membranes for Water Remediation

Zhang

Yang

Zhang

et al. 2022

Ind. Eng. Chem. Res.

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In past decades, membrane technology has been widely believed for water remediation and purification. However, the waste membranes, which is conventional nonbiodegradable polymeric materials, causes secondary pollution and hampers the application of membrane technology. As an industrialized biodegradable polymer, polylactic acid (PLA) is believed as an alternative to conventional polymeric membrane materials, while suffering from its intrinsic strong hydrophobic properties. Herein we provide a facile method to improve the hydrophilicity of PLA hollow-fiber membranes through tailoring the phase inversion process by introducing Tween-80 and polyvinylpyrrolidone K30 (PVP-K30) as coadditives. During the phase inversion process, Tween-80 enhances the dispersity of the PVP-K30 and promotes the shifts of the PVP-K30 toward the surface of the membrane through hydrogen bonding, tailoring the pore structure and the surface properties of the membranes. Consequently, the water permeance of the modified PLA membranes increases by 816.4% (151.2 L m–2 h–1 bar–1). Moreover, the membranes also demonstrate excellent antifouling performance with permeance recovery rate up to 86.8%, showing strong promise in substituting conventional polymer membranes for water remediation.

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Marine Algae-PLA composites as de novo alternative to porcine derived collagen membranes

Cited by 16 publications

References 36 publications

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

Algal-derived macromolecules and their composites: From synthetic biology to biomedical applications in bone and cardiovascular tissue engineering

Development of Hydrophilic Polylactic Acid Hollow-Fiber Membranes for Water Remediation

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