Marine Algae and Their Products and Constituents in Pharmacy

Hoppe, Heinz A.

doi:10.1515/9783110882049.25

Cited by 27 publications

(25 citation statements)

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“…From prehistoric times; seaweeds has been widely used as food [44,45] as these are the chief source of vitamins and minerals [46]. The extracts and its products are effective nutritional supplements [47].…”

Section: Medicinal and Pharmacological Propertiesmentioning

confidence: 99%

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Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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Seaweed research has been carried out for more than seven decades by many research workers. Research has been done separately in different aspects accordingly to our need. The main objective of the present review is to gather information relating to nutritional, pharmacological, clinical, biochemical, industrial uses and its application to human welfare. Seaweeds have a high concentration of essential vitamins, trace elements, proteins, lipids, polysaccharides, enzymes, and minerals as compared to terrestrial foodstuffs. These plants have been a source of food, fodder, medicine, cosmetics, energy, fertilizer and are used for industrial production of agar and alginate. Their recent utilization increases in poultry due to their nutritive value. In the present scenario, it is being used for wastewater treatment such as treatment of wastewater to reduce nitrogen and phosphorus containing compounds. This review work is an attempt to highlights all the relevant application and uses of seaweeds and its products. Finally, this paper would be helpful to a common man to know and aware about such a great living resources which is present in and around us.

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Section: Medicinal and Pharmacological Propertiesmentioning

confidence: 99%

“…These compounds are useful against various diseases such as viral, bacterial and fungal [46]. Several experiments and patents were carried out in ancient times by researchers to find out these chemical compounds which basically fall in categories of phaeophyceae, chlorophyceae and rhodophyceae [64,65].…”

Section: Antibiotic Activitymentioning

confidence: 99%

Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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“…Traditionally, some species of Nostoc have been used as a food source (Chu and Tsang 1988), and some have been used as medicine to treat cancer and gout (Hoppe 1979). A broad spectrum of antimicrobial compounds has been found in both cellular extracts and extracellular products of some species of Nostoc (e.g.…”

mentioning

confidence: 99%

STUDIES ON POLYSACCHARIDES FROM THREE EDIBLE SPECIES OF NOSTOC (CYANOBACTERIA) WITH DIFFERENT COLONY MORPHOLOGIES: COMPARISON OF MONOSACCHARIDE COMPOSITIONS AND VISCOSITIES OF POLYSACCHARIDES FROM FIELD COLONIES AND SUSPENSION CULTURES

Liu

Paulsen

Klaveness

1998

Journal of Phycology

111

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“…[13,14] Novel marine compounds and promising pharmacological research have been reviewed by many authors. [8,15,16] In this study, various solvent extracts of C. calcitrans and N. oculata were screened against human cancer cell lines using the MTT cytotoxicity assay [Table 1] based on Krebs cycle events in intact mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Crude ethyl acetate extract of marine microalga,Chaetoceros calcitrans, induces Apoptosis in MDA-MB-231 breast cancer cells

et al. 2014

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Background:Marine brown diatom Chaetoceros calcitrans and green microalga Nannochloropsis oculata are beneficial materials for various applications in the food, nutraceutical, pharmaceutical and cosmeceutical industries.Objective:This study investigated cytotoxicity of different crude solvent extracts from C. calcitrans and N. oculata against various cancer cell lines.Materials and Methods:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was carried out to screen the cytotoxic effects of hexane (Hex), dichloromethane (DCM), ethyl acetate, and methanol extract from C. calcitrans and N. oculata toward various cancer cell lines. Flow cytometry cell cycle was used to determine the cell cycle arrest while the mode of cell death was investigated through acridine orange/propidium iodide (AOPI) staining, Annexin V-Fluorescein Isothiocyanate (FITC) and Terminal deoxynucleotidyl transferase-mediated d-UTP Nick End Labeling (TUNEL) assays. Expression profile of apoptotic and proliferative-related genes was then determined using the multiplex gene expression profiler (GeXP).Results:Crude ethyl acetate (CEA) extract of C. calcitrans inhibited growth of MDA-MB-231 cells, with IC50 of 60 μg/mL after 72 h of treatment. Further studies were conducted to determine the mode of cell death at various concentrations of this extract: 30, 60 and 120 μg/mL. The mode of cell death was mainly apoptosis as shown through apoptosis determination test. The expression data from GeXP showed that caspase-4 was upregulated while B-cell leukemia/lymphoma 2(Bcl-2) was down regulated. Thus, caspase-4 induction endoplasmic reticulum death pathway is believed to be one of the mechanisms underlying the induction of apoptosis while Bcl-2 induced S and G2/M cell cycle phase arrest in MDA-MB-231 cells.Conclusion:CEA extract of C. calcitrans showed the highest cytotoxicity on MDA-MB-231 via apoptosis.

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Marine Algae and Their Products and Constituents in Pharmacy

Cited by 27 publications

References 0 publications

Uses of Seaweed and Its Application to Human Welfare: A Review

Uses of Seaweed and Its Application to Human Welfare: A Review

STUDIES ON POLYSACCHARIDES FROM THREE EDIBLE SPECIES OF NOSTOC (CYANOBACTERIA) WITH DIFFERENT COLONY MORPHOLOGIES: COMPARISON OF MONOSACCHARIDE COMPOSITIONS AND VISCOSITIES OF POLYSACCHARIDES FROM FIELD COLONIES AND SUSPENSION CULTURES

Crude ethyl acetate extract of marine microalga,Chaetoceros calcitrans, induces Apoptosis in MDA-MB-231 breast cancer cells

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