Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea

Zhu, Feng; Lin, Yongcheng

doi:10.1007/s11434-006-1426-4

Cited by 69 publications

(57 citation statements)

References 31 publications

(27 reference statements)

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“…8.5), whose structures were revised, indicating that they are pyrrolyl 4-quinolone analogues [108]. Compounds 310-311 were active against Pseudomonas pyocyanea and S. aureus, and exhibited potent cytotoxicity against HepG2, 95-D (lung), MGC832 (gastric), and HeLa tumor cell lines [103,108].…”

Section: Triggering Biosynthesis Of Novel Secondary Metabolitesmentioning

confidence: 99%

Endophytic Fungi as a Source of Novel Metabolites

2015

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Section: Triggering Biosynthesis Of Novel Secondary Metabolitesmentioning

confidence: 99%

Endophytic Fungi as a Source of Novel Metabolites

2015

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“…2 To overcome this problem, co-culture method draws attention to produce novel natural product and increase the productivity of known compounds. Until now, some examples, such as Gram-positive bacteria and Gram-positive bacteria, 3,4 Gram-positive bacteria and fungus, 5,6 Gram-negative bacteria and fungus, [7][8][9] and fungus and fungus, [10][11][12][13] were reported. In this background, we started to apply this co-culture method to discover new compounds.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655

et al. 2011

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In the course of discovering new metabolites from co-culture of Penicillium pinophilum FKI-5653 and Trichoderma harzianum FKI-5655, a new compound, designated secopenicillide C, and four known compounds, penicillide, MC-141, pestalasin A and stromemycin were isolated. The production of these compounds, except pestalasin A, was enhanced in co-culture to be two to six times higher than in pure culture of Penicillium pinophilum FKI-5653, which was the producer of these compounds.

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“…As part of our ongoing search for new bioactive metabolites from mixed fermentation of marine-derived mangrove fungi from the South China Sea [3,8], two antibacterial compounds, neoaspergillic acid and kojic acid, were obtained as major secondary metabolites from the mixed fermentation liquid of two marine-derived mangrove epiphytic Aspergillus fungi, which were isolated from a rotten fruit of mangrove Avicennia marina in the South China Sea [9]. Further chemical investigations of the mixed fermentation mycelia resulted in the isolation of a new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a commom compound, ergosterol (3).…”

mentioning

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Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

Zhu

Chen

et al. 2011

Chem Nat Compd

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A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1 H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.Application of mixed fermentation was proved to contribute to the discovery of new natural products from marinederived microorganisms. To date, at least nine new biologically active compounds have been identified by mixed fermentation of marine-derived microorganisms, pestalone [1], libertellenones A-D [2], marinamides A and B [3], and emericellamides A and B [4]. Results of mixed fermentation include increased antibiotic activity in the crude extract, increased yields of previously described metabolites, increased yields of previously undetected metabolites, analogues of known metabolites resulting from combined pathways, and induction of previously unexpected pathways for bioactive constituents [5].Marine-derived mangrove fungi were proved to be an abundant resource for novel natural compounds [6,7]. As part of our ongoing search for new bioactive metabolites from mixed fermentation of marine-derived mangrove fungi from the South China Sea [3,8], two antibacterial compounds, neoaspergillic acid and kojic acid, were obtained as major secondary metabolites from the mixed fermentation liquid of two marine-derived mangrove epiphytic Aspergillus fungi, which were isolated from a rotten fruit of mangrove Avicennia marina in the South China Sea [9]. Further chemical investigations of the mixed fermentation mycelia resulted in the isolation of a new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a commom compound, ergosterol (3). We report herein their isolation, structural elucidation, and antibacterial activities. Fig. 1. The structure and key HMBC correlations (from C to H) of compound 1.

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Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea

Cited by 69 publications

References 31 publications

Endophytic Fungi as a Source of Novel Metabolites

Endophytic Fungi as a Source of Novel Metabolites

Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655

Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

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