Marijuana and Coronary Dissection: A Case Report and Review of Literature

Kariyanna, Pramod Theetha; Chandrakumar, Harshith Priyan; Chowdhury, Yuvraj S.; Jayarangaiah, Apoorva; Das, Sushruth; Jayarangaiah, Amog; Salifu, Moro O.; McFarlane, Isabel M.

doi:10.12691/ajmcr-9-3-11

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…(Theetha Kariyanna et al, 2021). En un estudio realizado por Auger, N. et al Se demostró que las mujeres con trastornos por consumo de cannabis tuvieron una mayor incidencia de hospitalización cardiovascular que las mujeres no expuestas.…”

Section: Resultados Y Discusiónunclassified

Efectos adversos del consumo de marihuana en el sistema cardiovascular

Cortés

Teneda

2022

Ciencia Latina

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La marihuana es la droga ilícita que más se usa a nivel mundial, contiene más de 700 sustancias químicas diferentes, en las que se encuentran los fitocannabinoides, siendo los más conocidos el 9-tetrahidrocannabinol y cannabidiol. El ligando 9-tetrahidrocannabinol se une a múltiples receptores con una selectividad especialmente alta para los receptores cannabinoides 1, que se expresan predominantemente en el sistema cardiovascular, el sistema nervioso central y en la vasculatura periférica en el cerebro. Existe evidencia que sugiere que una mayor frecuencia de consumo de marihuana aumenta el riesgo de arritmias cardíacas e infarto de miocardio. El objetivo de esta investigación fue relacionar el consumo crónico de marihuana con el desarrollo de efectos adversos en el sistema cardiovascular. Se realizó una búsqueda en diferentes bases de datos como Google Scholar, PubMed, Embase, Elseiver, Latindex, y Scielo, se seleccionaron 35 resúmenes de artículos tanto en español como inglés, publicados desde el año 2018 hasta junio de 2022 para su revisión de los cuales 11 fueron seleccionados para el desarrollo de esta revisión

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Section: Resultados Y Discusiónunclassified

Efectos adversos del consumo de marihuana en el sistema cardiovascular

Cortés

Teneda

2022

Ciencia Latina

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Recreational Marijuana Use and Coronary Artery Dissection: A Case Series

Adeniyi¹,

Abadir²,

Kooshkabadi³

et al. 2022

Cureus

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The cardiovascular effects of marijuana have been shown to be a result of the activation of the CB1 and CB2 receptors located in the myocardium and coronary vasculatures. Adverse cardiovascular consequences of recreational use of marijuana and synthetic cannabinoids include stroke, artery dissection, vasospasm, vasculitis, coronary artery thrombosis, myocarditis/pericarditis, postural hypotension, arrhythmias, and acute heart failure. With marijuana being legalized for medicinal purposes and recreational use in more and more states in the United States, physicians should have a low threshold for the possibility of marijuana being the underlying cause of adverse cardiovascular events. Marijuana has been established to increase sympathetic tone and cause blood pressure elevations and severe coronary artery spasm (CAS). Some studies have even indicated that the risks of heart attack, atrial fibrillation, and ischemic stroke are several times higher within an hour of marijuana use. This case series discusses three female patients, aged 27, 39, and 53 years, who were known to smoke marijuana consistently. These patients all presented with signs and symptoms of acute coronary syndrome (ACS) less than 12 hours after smoking recreational marijuana. All patients endorsed smoking marijuana a few hours prior to the onset of chest pain and less than 12 hours prior to the presentation, which was confirmed by a positive urine drug screen (UDS). Coronary artery angiograms revealed coronary artery dissection in the proximal left circumflex (LCX) artery, the mid-distal left anterior descending (LAD) artery, and mid-LAD in the 27 y/o, 39 y/o, and 53 y/o patients respectively. The average age of spontaneous coronary artery dissection (SCAD) cases ranges between 35-40 years. Women account for more than 70% of cases; it is thought to be due to higher levels of estrogen in women, which alters the normal arterial wall architecture. Additionally, the excessive use of marijuana resulting in CAS further increases the susceptibility to spontaneous dissection in female patients.

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Spontaneous Coronary Artery Dissection Presenting As ST-Segment Elevation Myocardial Infarction

Taha¹,

Daly²,

Shah³

et al. 2022

Cureus

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Spontaneous coronary artery dissection (SCAD) is a non-traumatic spontaneous separation of a coronary wall that can present as acute myocardial infarction. Pregnant females are already at a considerably higher risk of acute myocardial infarction when compared to non-pregnant women of child-bearing age, and dissection explains the majority of these cases. Here, we present a 36-year-old female at 36-weeks gestation who experienced ventricular fibrillation arrest after ST-segment elevation myocardial infarction (STEMI) secondary to spontaneous dissection of the left anterior descending (LAD) coronary artery.

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Marijuana and Coronary Dissection: A Case Report and Review of Literature

Cited by 4 publications

References 18 publications

Efectos adversos del consumo de marihuana en el sistema cardiovascular

Efectos adversos del consumo de marihuana en el sistema cardiovascular

Recreational Marijuana Use and Coronary Artery Dissection: A Case Series

Spontaneous Coronary Artery Dissection Presenting As ST-Segment Elevation Myocardial Infarction

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