Marie Curie and the Discovery of Radium

Carvalho, Fernando P.

doi:10.1007/978-3-642-22122-4_1

Cited by 10 publications

(8 citation statements)

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“…Now there is time to humanize the the work. Although the path from basic discovery to scientific and technological applications isn't smooth and scientific work is not always the same form it's point of discovery to its actual use [31,32] ( Figure 5).…”

Section: An Unanswered Question: Investment In Clinical Trials or Dismentioning

confidence: 99%

Translational Science: Turning Discovery into Health

Butt¹,

Mir²,

Tariq³

et al. 2018

Transl Med

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Section: An Unanswered Question: Investment In Clinical Trials or Dismentioning

confidence: 99%

Translational Science: Turning Discovery into Health

Butt¹,

Mir²,

Tariq³

et al. 2018

Transl Med

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show abstract

“…Then, the discovery of radium by Madame Curie in 1898 and the almost accidental discovery by Henri Becquerel and Pierre Curie that radium salts could cause skin burns and therefore could be used in skin cancer treatment fostered interest in radium production, which became the aim of uranium mining, first in Europe and worldwide afterwards [9].…”

Section: Uranium Mining and Legacy Sitesmentioning

confidence: 99%

“…In 1945, by the end of World War II, with the control of the first nuclear fission reaction, uranium became a valuable metal and radium gradually lost its place in the market, especially after radium replacement in medical radiation sources by cesium and cobalt radioisotopes [9].…”

Section: Uranium Mining and Legacy Sitesmentioning

confidence: 99%

“…In the meantime, new mines were opened in Niger, Malawi and Namibia and more African states plan to start uranium production. Meanwhile, large uranium producers, namely the USA, Canada and Australia, closed some mine sites, maintained others in operation and opened new mines [8][9][10][11]. Today, many countries have a legacy of waste repositories with radioactive materials from past uranium mining and milling operations.…”

Section: Uranium Mining and Legacy Sitesmentioning

confidence: 99%

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Uranium mining and milling: the need for reference materials in environmental radioactivity monitoring programmes

Carvalho

Edge

2013

International Journal of Environmental Studies

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Environmental radioactivity monitoring programmes are now implemented in many countries around legacy uranium mining and milling sites and current uranium mining sites and include, for example, the analyses of soil, plant, meat and water samples. Often, there are legal requirements on periodic reporting of this monitoring. The results are used to assess compliance with the standards for radiation exposure of the public. To provide quality assurance, there is a need for reference materials (RMs) for use in monitoring programmes related to assessment of environmental contamination, uranium waste management and radiation protection in uranium areas. Reliable uranium supply to satisfy the increasing demand for low-carbon electricity production needs to meet the increasing environmental and health safety standards and public concerns for responsible information.

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“…The energy associated with the bonds in organic compounds (<10 eV) is much lower than the energy dissipated per ionization event (33 eV) [13,14]. Following the characterization of radioactivity by Marie Curie in the late nineteenth century, Pierre Curie demonstrated the cell killing ability of ionizing radiation by holding a tube of radium against his arm to produce an ulceration [15,16]. This newly discovered alkaline earth metal was quickly found to exhibit cancer suppressing properties upon insertion into tumors, resulting in an entirely new form of treatment referred to as brachytherapy.…”

Section: Applications Of Radiopharmaceuticalsmentioning

confidence: 99%

Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent

Charles¹

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The continued development of methods for the production and separation of high specific activity (HSA) rhenium-186 (t1/2 = 90.64 h, Eb-ave = 359 keV (71 percent), 306 keV (22 percent)) would largely increase its use as a therapeutic analogue to the widely used 99mTc (t1/2 = 6.01 h, Eg = 141 keV (89 percent)). Rhenium-186 has favorable decay properties that make it an attractive candidate for radioimmunotherapy, providing that the radionuclide can be obtained in high specific activity. The similar chemical characteristics of Re and Tc in theory may allow 186Re-based radiopharmaceuticals to be developed as therapeutic analogues to their 99mTc counterparts. In this research, two methods were evaluated for the production and separation of HSA 186Re, and several methods were also evaluated for their efficiency in the selective separation of 186Re post production, as well as high recovery of the costly enriched target material. Yttrium-90 (t1/2 = 64 h, Eb-max = 2.28 MeV (99.99 percent)) also displays excellent decay properties for targeted radiotherapy, which is exploited by the formulation of a novel liquid brachytherapy agent, BetaBrachTM. The HSA 90Y utilized for the current formulation of BetaBrachTM can be replaced by low specific activity (LSA) 90Y produced in a nuclear reactor. Replacing HSA 90Y with LSA 90Y may offer significant economic advantages if the demand for BetaBrachTM requires large scale production of 90Y. Thus, this work also evaluates the chemical and physical characterization of LSA 90Y formulated BetaBrachTM as well as its therapeutic efficacy.

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Marie Curie and the Discovery of Radium

Cited by 10 publications

References 1 publication

Translational Science: Turning Discovery into Health

Translational Science: Turning Discovery into Health

Uranium mining and milling: the need for reference materials in environmental radioactivity monitoring programmes

Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent

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