Marginal and segmental mandibulectomy in patients with oral cancer: a statistical analysis of 106 cases

Muñoz-Guerra, M.F.; Gı́as, Luis Naval; Campo, F. Rodríguez; Pérez, José Pedro López

doi:10.1016/s0278-2391(03)00730-4

Cited by 102 publications

(30 citation statements)

References 27 publications

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“…Kawakita et al (8) conducted a retrospective cohort analysis of 222 patients with OSCC, in which they assessed the association between smoking status of patients and clinical outcome. Furthermore, Munoz Guerra et al (11) analyzed a 20-year cohort of 106 patients to assess the association between a worse prognosis and factors related to the surgical treatment of oral cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the identification of factors associated with a poor prognosis has emerged as an important issue in the management of OSCC. Previous studies have evaluated various clinicopathological parameters as prognostic factors of OSCC, and the age (7) and smoking status (8) of patients, extracapsular spread in the cervical lymph nodes (9), TNM stage (5,10), status of the surgical resection margin, bone involvement and the size of the mandibulectomy (11), as well as the tumor size and microvascular invasion (12,13), have been shown to be independent prognostic factors in patients with OSCC. However, previous studies have assessed only few or groups of risk factors that might influence the prognosis, and the association between these factors and the prognosis of OSCC is inconsistent and complex.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays

et al. 2016

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The aim of this study was to evaluate clinicopathological risk factors associated with the fatal outcome of oral squamous cell carcinoma (OSCC) in a large cohort of Chinese patients, and to construct tissue microarrays (TMAs) using this cohort. Univariate and multiple logistic regression analyses were performed to evaluate the predictors of poor prognosis in a cohort of 232 patients with OSCC, after which the patient tumor tissues were used to construct TMAs. Univariate logistic regression analysis indicated that a poor outcome of OSCC was associated with the male gender, a history of smoking, the tumor-node-metastasis stage and lymph node metastasis. Multiple logistic regression analysis demonstrated that an increased risk of mortality in patients with OSCC was significantly and independently associated with lymph node metastasis (odds ratio, 3.421; 95% confidence interval, 1.609–7.273). Therefore, the results of the present study suggested that lymph node metastasis is an independent risk factor associated with a poor prognosis of OSCC patients. TMAs of OSCC were successfully constructed, and are the first TMAs to be reported in mainland Chinese patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays

et al. 2016

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“…Thus, the radiation treatment intended to prevent recurrence in cancer patients can lead to complications such as osteoradionecrosis [64], resulting in failure of the graft and revision surgeries [63]. Despite these aggressive therapies of large surgical margins and radiation, recent studies have reported recurrence rates varying between 13 – 34% after mandibulectomy, which underscores the need for new approaches for reducing tumor recurrence while improving healing [58, 60, 61, 65, 66]. …”

Section: Strategies For Healing Bone Damaged By Cancer-induced Diseasementioning

confidence: 99%

Biomaterial Scaffolds for Treating Osteoporotic Bone

Sterling

Guelcher

2014

Curr Osteoporos Rep

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Healing fractures resulting from osteoporosis or cancer remains a significant clinical challenge. In these populations, healing is often impaired not only due to age and disease, but also by other therapeutic interventions such as radiation, steroids, and chemotherapy. Despite substantial improvements in the treatment of osteoporosis over the few decades, osteoporotic fractures are still a major clinical challenge in the elderly population due to impaired healing. Similar fractures with impaired healing are also prevalent in cancer patients, especially those with tumor growing in bone. Treatment options for cancer patients are further complicated by the fact that bone anabolic therapies are contraindicated in patients with tumors. Therefore, many patients undergo surgery to repair the fracture, and bone grafts are often used to stabilize orthopaedic implants and provide a scaffold for ingrowth of new bone. Both synthetic and naturally occurring biomaterials have been investigated as bone grafts for repair of osteoporotic fractures, including calcium phosphate bone cements, resorbable polymers, and allograft or autograft bone. In order to re-establish normal bone repair, bone grafts have been augmented with anabolic agents, such as mesenchymal stem cells (MSC) or recombinant human bone morphogenetic protein-2 (rhBMP2). These developing approaches to bone grafting are anticipated to improve the clinical management of osteoporotic and cancer-induced fractures.

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“…A marginal mandibulectomy is an oncologic procedure performed in conjunction with local soft‐tissue ablation that is performed when oral cancers approach or superficially involve the periosteum of the mandible. In the appropriately selected patients, it achieves excellent local control and survival rates 1. These composite resections of the anterior oral cavity resulting in variable loss of the ventral tongue, floor of mouth, and mandible have had a number of proposed reconstructive options.…”

Section: Introductionmentioning

confidence: 99%