Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays

Jin, Xin; Liu, Dongjuan; Zhao, Xin; Zhou, Yu; Jiang, Lu; Li, Jing; Zeng, Xin; Chen, Qianming

doi:10.3892/ol.2016.5120

Cited by 13 publications

(12 citation statements)

References 37 publications

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“…Both high Axin2 expression and high Snail expression showed a significant association with T stage (p < 0.001 and p = 0.031), lymph node metastasis (both p < 0.001), vascular invasion (p = 0.01 and p = 0.019), and bone invasion (p < 0.001 and p = 0.028) in the present study. The sex differences in the prognosis of OSCC patients remain controversial [34]. In our study, we did not find a significant association between sex and the prognosis of OSCC.…”

Section: Clinicopathological Significance Of Axin2 and Snail Expressicontrasting

confidence: 87%

The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

Cho

Ling

et al. 2020

BMC Cancer

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Background In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. Methods The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples from patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behaviour of OSCC cells and CAFs was further investigated both in vitro and in vivo. Results Axin2 expression was significantly associated with Snail expression, the desmoplasia status, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2 expression, and Snail expression were independent poor prognostic factors in our cohort. Consistent with these findings, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro. Among the related cytokines, C-C motif chemokine ligand 5 (CCL5) and interleukin 8 (IL8) demonstrated a strong influence on the biological behaviour of CAFs in vitro. Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using a BALB/c athymic nude mouse xenograft model. Conclusions Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves but rather extend to CAFs via regulation of the cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as a poor prognosis in OSCC.

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Section: Clinicopathological Significance Of Axin2 and Snail Expressicontrasting

confidence: 87%

The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

Cho

Ling

et al. 2020

BMC Cancer

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show abstract

“…Both high Axin2 expression and high Snail expression showed a signi cant association with T stage (p<0.001 and p=0.031), lymph node metastasis (both p<0.001), vascular invasion (p=0.01 and p=0.019), and bone invasion (p<0.001 and p=0.028) in the present study. The sex differences in the prognosis of OSCC patients remain controversial [34]. In our study, we did not nd a signi cant association between sex and the prognosis of OSCC.…”

Section: Clinicopathological Signi Cance Of Axin2 and Snail Expressiocontrasting

confidence: 81%

The Axin2-Snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

Cho

Ling

et al. 2020

Preprint

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Background : In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. Methods : The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples from patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behaviour of OSCC cells and CAFs was further investigated both in vitro and in vivo . Results : Axin2 expression was significantly associated with Snail expression, the desmoplasia status, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2 expression, and Snail expression were independent poor prognostic factors in our cohort. Consistent with these findings, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro . Among the related cytokines, C-C motif chemokine ligand 5 (CCL5) and interleukin 8 (IL8) demonstrated a strong influence on the biological behaviour of CAFs in vitro . Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using a BALB/c athymic nude mouse xenograft model. Conclusions : Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves but rather extend to CAFs via regulation of the cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as a poor prognosis in OSCC.

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“…Oral cancer (OC) is one of the most common cancers that dominates globally and is known for its lethal effects and disastrous outcomes (Jin et al, 2016). Oral Squamous cell carcinoma (OSCC) constitutes about ninety percent of all oral malignancies (Feller et al, 2013) and is ranked as the eighth most common cancer world-wide (Abdulla et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessing Knowledge, Attitude and Practices for Oral Squamous Cell Carcinoma among Health Care Professionals in Princess Nourah University, Riyadh, KSA

Kazmi

Alkait

Alghamdi

et al. 2020

Asian Pac J Cancer Prev

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Background: Oral Squamous Cell Carcinoma (OSCC) is a growing public health problem affecting 2.2 million of the world's population per year and the rates are increasing annually. The disease is usually diagnosed in later stages, and carries high morbidity and mortality rates worldwide. Proper awareness among health care professionals (HCP) is the most significant factor for ensuring early diagnosis and treatment. They should have thorough knowledge to identify all suspicious lesions or otherwise to seek specialist opinion when unsure. The present study aimed to assess the knowledge, attitude, and practices (KAPs) of OSCC among dental and medical undergraduate students along with general practitioners and specialists of both disciplines. Materials and Methods: The present cross-sectional study was conducted at Princess Nourah Bint Abdulrahman University and its affiliated hospital. A total of 332 participants filled a close-ended online questionnaire. Responses to the questionnaire were analyzed using descriptive and analytical statistics. Results: Of the 450 health care professionals approached, 332 filled the questionnaire with a response rate of 73.77.%. It was observed that the mean knowledge index was higher among dental participants (10.96 ± 1.85). The attitude index was higher at medical side (6.89 ± 1.11), and the practice index was also higher among the dental participants (4.95 ± 0.91). Most of the health care professionals had knowledge regarding risk factors associated with OSCC. HCPs indicated their lack of training as the main barrier for conducting a comprehensive examination for OSCC. Interestingly, the vast majority of HCPs expressed their interest to have further educational and training sessions regarding this malignancy. Conclusion: The study puts forward, the need for intensive training and workshops for awareness and improvement of the abilities of the HCPs, (including dental and medical undergraduate students along with practitioners and specialists) to diagnose OSCC.

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Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays

Cited by 13 publications

References 37 publications

The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

The Axin2-Snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

Assessing Knowledge, Attitude and Practices for Oral Squamous Cell Carcinoma among Health Care Professionals in Princess Nourah University, Riyadh, KSA

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