Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response

Yang, Wenchang; Tao, Kaixiong; Zhang, Peng; Chen, Xin; Sun, Xiaoli; Li, Ruidong

doi:10.1016/j.bcp.2021.114863

Cited by 46 publications

(27 citation statements)

References 37 publications

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“…Programmed cell death ligand 1 (PD-L1) inhibitors kill tumor cells by triggering pyroptosis (65), while IL-17 promotes PD-L1 expression in tumor cells by PD-1+ immune cell intratumor infiltration (66), suggesting that IL-17 may be a potential target for enhancing the performance of PD-L1 inhibitors by increasing pyroptosis of tumor cells. We observed a higher infiltration of macrophages in Class1, while it has been reported that macrophages can release reactive oxygen species (ROS) and thus trigger pyroptosis (67). The oxidation-related gene GPX4 could affect the prognosis of PCa patients, suggesting the redox response may have an interplay with pyroptosis in PCa.…”

Section: Discussionmentioning

confidence: 62%

Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Luo

et al. 2022

Front. Endocrinol.

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BackgroundEmerging evidence suggests an important role for pyroptosis in tumorigenesis and recurrence, but it remains to be elucidated in prostate cancer (PCa). Considering the low accuracy of common clinical predictors of PCa recurrence, we aimed to develop a novel pyroptosis-related signature to predict the prognosis of PCa patients based on integrative analyses of bulk and single-cell RNA sequencing (RNA-seq) profiling.MethodsThe RNA-seq data of PCa patients was downloaded from several online databases. PCa patients were stratified into two Classes by unsupervised clustering. A novel signature was constructed by Cox and the Least Absolute Shrinkage and Selection Operator (LASSO) regression. The Kaplan-Meier curve was employed to evaluate the prognostic value of this signature and the single sample Gene Set Enrichment Analysis (ssGSEA) algorithm was used to analysis tumor-infiltrating immune cells. At single-cell level, we also classified the malignant cells into two Classes and constructed cell developmental trajectories and cell-cell interaction networks. Furthermore, RT-qPCR and immunofluorescence were used to validate the expression of core pyroptosis-related genes.ResultsTwelve prognostic pyroptosis-related genes were identified and used to classify PCa patients into two prognostic Classes. We constructed a signature that identified PCa patients with different risks of recurrence and the risk score was proven to be an independent predictor of the recurrence free survival (RFS). Patients in the high-risk group had a significantly lower RFS (P<0.001). The expression of various immune cells differed between the two Classes. At the single-cell level, we classified the malignant cells into two Classes and described the heterogeneity. In addition, we observed that malignant cells may shift from Class1 to Class2 and thus have a worse prognosis.ConclusionWe have constructed a robust pyroptosis-related signature to predict the RFS of PCa patients and described the heterogeneity of prostate cancer cells in terms of pyroptosis.

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Section: Discussionmentioning

confidence: 62%

Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Luo

et al. 2022

Front. Endocrinol.

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“…23 , 35 , 36 Previous research has shown that inflammatory responses, oxidative stress, endoplasmic reticulum (ER) stress, and apoptosis mainly contributed to LPS/D-GalN-induced ALF. 30 , 37 , 38 , 39 , 40 However, Liu et al 41 and Yang et al 42 found that pyroptosis occurred in LPS/D-GalN-induced ALF through activating caspase 1 and inflammasome NLR family pyrin domain containing 3 (NLRP3). Studies also showed that ferroptosis took place in LPS/D-GalN-induced ALF by increasing lipid peroxidation with cyclooxygenase (COX) and lysyl oxidase (LOX) pathway up-regulation and inhibiting GSH synthesis.…”

Section: Discussionmentioning

confidence: 99%

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis

Huang

Wang

Xie

et al. 2022

Cellular and Molecular Gastroenterology and Hepatology

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“…Firstly, because as detailed above, there is extensive documentation from many groups (including some of the co-authors of O’Donnell et al 1, 2, 3, 4, 5, 6, 7, 8 ) which identify and quantitate SPM in an array of biological systems. Indeed, as discussed above, a PubMed search term of “resolvins” gives 1,420 reports (as of today) from groups around the world using commercially available resolvins and other SPMs confirming their potent stereoselective actions in a wide range of models and presence in human tissue samples 3, 9, 10, 11, 12, 13, 14, 15, 16 . Secondly, while it is the case that the different entities mentioned by the authors have recommended the used of s/n ratios as an analytical criterion, the suggestion made by O’Donnell et al ,that this is the only criterion recommended by these entities is not fact.…”

Section: Main Textmentioning

confidence: 99%

Evidence for the presence and diagnostic utility of SPM in human peripheral blood

Dalli

Gómez

Serhan

2022

Preprint

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SummaryWe thank O’Donnell et al, for their comments on our contribution and are grateful to be afforded this opportunity to formally respond to their critique24.We are surprised by the author’s assertion relating to the biological relevance of SPM because a simple literature search for related terms such as ‘resolvin’ in PubMed yields an abundance (>1,420 publications) of evidence supporting the potent biological activities and the diagnostic potential of some of these mediators. Several co-authors of the O’Donnell’s et al manuscript, have published on the resolvins and SPMs, including some publications within recent weeks. Importantly, O’Donnell et al, misreport as well as mis-apply criteria for peak identification reported in the Gomez et al, publication which lead to the flawed analysis they performed.In this response therefore, we provide a step-by-step clarification of the methodologies used in Gomez et al, and a side-by-side comparison of the underlying data to clarify any confusion. We also demonstrate that using the orthogonal criteria discussed by O’Donnell et al, we obtain essentially identical results thus providing additional validation of our techniques and support the conclusions.

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Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response

Cited by 46 publications

References 37 publications

Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis

Evidence for the presence and diagnostic utility of SPM in human peripheral blood

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