Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Fu, Jianhan; Li, Guoqiang; Luo, Ruixiang; Lu, Zhijie; Wang, Yinhuai

doi:10.3389/fendo.2022.1003594

Cited by 6 publications

(3 citation statements)

References 69 publications

(74 reference statements)

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“…They constructed a prognostic signature based on these PRGs, their expression profile, a clinical database that can be used to precisely predict BCR after radical intervention, which is a determining risk factor for PCa specificity and distant metastasis, and the progression-free survival (PFS) rate [87]. Other researchers who repeated this work verified that the identified PRGs were closely related to carcinogenesis, tumor cell invasion, and the immune microenvironment in PCa [88,89].…”

Section: Role Of Pyroptosis In Prostate Cancermentioning

confidence: 97%

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis

Zhu,

Liu,

Liu

et al. 2023

Biomolecules

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Prostate cancer (PCa) is a complex disease and the cause of one of the highest cancer-related mortalities in men worldwide. Annually, more than 1.2 million new cases are diagnosed globally, accounting for 7% of newly diagnosed cancers in men. Programmed cell death (PCD) plays an essential role in removing infected, functionally dispensable, or potentially neoplastic cells. Apoptosis is the canonical form of PCD with no inflammatory responses elicited, and the close relationship between apoptosis and PCa has been well studied. Necroptosis and pyroptosis are two lytic forms of PCD that result in the release of intracellular contents, which induce inflammatory responses. An increasing number of studies have confirmed that necroptosis and pyroptosis are also closely related to the occurrence and progression of PCa. Recently, a novel form of PCD named PANoptosis, which is a combination of apoptosis, necroptosis, and pyroptosis, revealed the attached connection among them and may be a promising target for PCa. Apoptosis, necroptosis, pyroptosis, and PANoptosis are good examples to better understand the mechanism underlying PCD in PCa. This review aims to summarize the emerging roles and therapeutic potential of apoptosis, necroptosis, pyroptosis, and PANoptosis in PCa.

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Section: Role Of Pyroptosis In Prostate Cancermentioning

confidence: 97%

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis

Zhu,

Liu,

Liu

et al. 2023

Biomolecules

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“…The authors established a novel prognostic gene signature for predicting the recurrence free survival in PCa patients, which was shown to be an independent factor associated with the recurrence free survival in PCa. [ 103 ] Xiao et al established a prognostic risk model using a 6-hub PRG. By analyzing its relationship with PCa in terms of clinicopathological characteristics, tumor immune microenvironment and response to drug treatment, it was found that this risk model was of good clinical significance.…”

Section: Role Of Pyroptosis In Pcamentioning

confidence: 99%

A review focusing on the role of pyroptosis in prostate cancer

Liu,

Kuang,

Chen

2023

Medicine

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As one of the types of programmed cell death, pyroptosis has become a focus of research in recent years. Numerous studies have shown that pyroptosis plays a regulatory role in tumor cell invasiveness, differentiation, proliferation, and metastasis. It has been demonstrated that pyroptosis is involved in the regulation of signaling pathways implicated in the pathogenesis of prostate cancer (PCa). Furthermore, the loss of expression of pyroptosis-related genes in PCa has been reported, and pyroptosis-related genes have demonstrated a considerable ability in predicting the prognosis of PCa. Therefore, the potential role of pyroptosis in regulating the development of PCa warrants further investigation and attention. In this review, we summarize the basics of the role of pyroptosis and also discuss research into the mechanisms of action associated with pyroptosis in PCa. It is hoped that by exploring the potential of the pyroptosis pathway in intervening in PCa, it will provide a viable direction for the diversification of PCa treatment.

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“…Pyroptosis appears to play a significant role in tumor progression and is linked to proliferation, migration, cell cycle, and treatment resistance in various of cancers, according to accumulated evidence ( Heo et al, 2019 ; Yu et al, 2019 ; Tan et al, 2021 ). Recent studies have found that pyroptosis-related genes (PRGs) have satisfactory predictive abilities in the prognosis of PCa and could be used as novel tumor biomarkers ( Fu et al, 2022 ; Hu et al, 2022 ; Wang et al, 2022 ). Meanwhile, its relationship with PCa immunity may provide assistance in the treatment of PCa ( Li et al, 2022 ; Zhang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A novel signature based on pyroptosis-related genes for predicting prognosis and treatment response in prostate cancer patients

Xiao

Wan

et al. 2022

Front. Genet.

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Background: Pyroptosis is a form of programmed cell death accompanied by specific inflammatory and immune responses, and it is closely related to the occurrence and progression of various cancers. However, the roles of pyroptosis-related genes (PRGs) in the prognosis, treatment response, and tumor microenvironment (TME) of prostate cancer (PCa) remain to be investigated.Methods: The mRNA expression data and clinical information of PCa patients were obtained from the Cancer Genome Atlas database (TCGA) and the cBioPortal for Cancer Genomics website, and the 52 PRGs were obtained from the published papers. The univariate, multivariate, and LASSO Cox regression algorithms were used to obtain prognostic hub PRGs. Meanwhile, qRT-PCR was used to validate the expression of hub genes between PCa lines and normal prostate epithelial cell lines. We then constructed and validated a risk model associated with the patient’s disease-free survival (DFS). Finally, the relationships between risk score and clinicopathological characteristics, tumor immune microenvironment, and drug treatment response of PCa were systematically analyzed.Results: A prognostic risk model was constructed with 6 hub PRGs (CHMP4C, GSDMB, NOD2, PLCG1, CYCS, GPX4), and patients were divided into high and low-risk groups by median risk score. The risk score was confirmed to be an independent prognostic factor for PCa in both the training and external validation sets. Patients in the high-risk group had a worse prognosis than those in the low-risk group, and they had more increased somatic mutations, higher immune cell infiltration and higher expression of immune checkpoint-related genes. Moreover, they were more sensitive to cell cycle-related chemotherapeutic drugs and might be more responsive to immunotherapy.Conclusion: In our study, pyroptosis played a significant role in the management of the prognosis and tumor microenvironment of PCa. Meanwhile, the established model might help to develop more effective individual treatment strategies.

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Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing

Cited by 6 publications

References 69 publications

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis

A review focusing on the role of pyroptosis in prostate cancer

A novel signature based on pyroptosis-related genes for predicting prognosis and treatment response in prostate cancer patients

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