March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Kishta, Osama A.; Sabourin, Antoine; Simon, Leora; McGovern, Toby K.; Raymond, Maxime; Galbas, Tristan; Majdoubi, Abdelilah; Ishido, Satoshi; Martin, James G.; Thibodeau, Jacques

doi:10.1155/2018/3823910

Cited by 17 publications

(9 citation statements)

References 69 publications

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“…Several E3 ubiquitin ligases like LUBAC, MARCH, and TRIM try to modulate the immunological response during viral infection. [182][183][184] Their coordinated actions safeguard the immune response to be nondamaging. Perhaps the viral proteins try to invade the balance between the productions of immune response by targeting key regulators of the pathways using E3 ubiquitin ligases.…”

Section: Understanding the Function Of Eubiquitin Ligases In Virus-me...mentioning

confidence: 99%

Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Dubey

Jagtap

Kumar

et al. 2021

J of Cellular Biochemistry

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Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective substrates for intracellular degradation. Still, we do not understand how ubiquitin proteasome system-based enzymes E3 ubiquitin ligases do their

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Section: Understanding the Function Of Eubiquitin Ligases In Virus-me...mentioning

confidence: 99%

Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Dubey

Jagtap

Kumar

et al. 2021

J of Cellular Biochemistry

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“…51 The protein of HUWE1 might function as an E3 ubiquitin ligase that played a role in modulating allergic responses. 52…”

Section: Articlementioning

confidence: 99%

Broad‐Spectrum Profiling of Drug Safety via Learning Complex Network

Liu

Ding

Han

et al. 2020

Clin Pharma and Therapeutics

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Drug safety is a severe clinical pharmacology and toxicology problem that has caused immense medical and social burdens every year. Regretfully, a reproducible method to assess drug safety systematically and quantitatively is still missing. In this study, we developed an advanced machine learning model for de novo drug safety assessment by solving the multilayer drug-gene-adverse drug reaction (ADR) interaction network. For the first time, the drug safety was assessed in a broad landscape of 1,156 distinct ADRs. We also designed a parameter ToxicityScore to quantify the overall drug safety. Moreover, we determined association strength for every 3,807,631 gene-ADR interactions, which clues mechanistic exploration of ADRs. For convenience, we deployed the model as a web service ADRAlertgene at http://www.bio-add.org/ADRAl ert/. In summary, this study offers insights into prioritizing safe drug therapy. It helps reduce the attrition rate of new drug discovery by providing a reliable ADR profile in the early preclinical stage.Drug safety is a severe clinical problem in drug therapy. It has caused immense medical and social burdens around the world every year. Drug safety research answers why a particular drug causes side effects or adverse drug reactions (ADRs) in a particular patient. The World Health Organization (WHO) defines ADR as "responses to a medicine which is noxious and unintended, and which occurs at doses normally used in man." Severe ADRs (SADRs) often lead to hospitalization, prolonged hospital staying, increased cost of care, disability, and even death. [1][2][3] It was reported that fatal ADRs answered for more than 100,000 deaths in US hospitals in 1994. 4 The ADR-related mortality increased significantly over time at a rate of 0.58% per year since 1999. 5 Besides, ADRs accounted for about 24% of all failures in clinical trials of new drug discovery, second to unsatisfied efficacy. 6 Therefore, it is extremely important to monitor and assess drug safety throughout the life cycle of drug development, from early drug discovery to postmarket surveillance. 7 Conventionally, both in vitro and in vivo tests are undertaken before clinical trials to help rapidly remove those highly toxic drugs. Be that as it may, > 20% of drug candidates still failed in clinical trials due to their poor toxicity profiles. 8 Regretfully, the toxicity information collected from cell experiments, like MTT assays and animal studies, cannot be fully transferred to humans if they are not interpreted prudently. More reliable ADR profiles are usually created in clinical trials among small but carefully recruited patient populations and from

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“…14,15 Airway hyperresponsiveness and the levels of inflammatory cytokines are lower in the lung tissues of OVA-induced asthmatic March1 −/mice than wide-type mice, suggesting March1 may play a crucial role in the development of asthma. 16 Acetylation also participates in the regulation of asthma development. Histone deacetylase11 (HDAC11) is the newest member of the histone deacetylase (HDAC) family and the only class IV histone deacetylase.…”

Section: Introductionmentioning

confidence: 99%

“… 14 , 15 Airway hyperresponsiveness and the levels of inflammatory cytokines are lower in the lung tissues of OVA-induced asthmatic March1 −/- mice than wide-type mice, suggesting March1 may play a crucial role in the development of asthma. 16 …”

Section: Introductionmentioning

confidence: 99%

E3 Ubiquitin Ligase March1 Facilitates OX40L Expression in Allergen-Stimulated Dendritic Cells Through Mediating the Ubiquitination of HDAC11

Zhang¹,

Sun²,

Guo³

et al. 2021

JAA

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Background: It was demonstrated that membrane-associated RING-CH 1 (March 1) might play an important role in the pathogenesis of asthma. Methods: The levels of mRNA and protein were measured by qRT-PCR and Western blot, respectively. Immunofluorescence assay was used to determine whether March1 co-locates with HDAC11. Co-immunoprecipitation was performed to examine the combination of proteins. Moreover, luciferase assay was used to measure the promoter activity of genes. Results: The mRNA and protein levels of both March1 and OX40 ligand (OX40L) were increased in the dendritic cells (DCs) from asthmatic children and asthmatic animals. Histone deacetylase 11 (HDAC11) protein was decreased in the DCs from asthmatic children and asthmatic model. Increasing of March1 or decreasing of March1 only affect the expression of HDAC11 in protein level. Besides, increasing of HDAC11 could inhibit OX40L expression, and decreasing of HDAC11 promoted OX40L expression in house dust mites (HDMs)-treated DCs. Increasing of HDAC11 notably reversed the promotion of March1 to OX40L expression. Our data further proved that March1 reduced the protein level of HDAC11 through inducing ubiquitination and degradation. HDAC11 combined with krüppel-like factor 4 (KLF4) to decrease the activity of OX40L gene promoter, thus to downregulate the level of OX40L. Conclusion: Overall, our data showed that HDAC11 promoted KLF4-dependent OX40L decreasing. However, March1 promoted OX40L expression through enhancing the ubiquitination and degradation of HDAC11 and subsequent blocking the inhibition of HDAC11 to OX40L.

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March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Cited by 17 publications

References 69 publications

Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Broad‐Spectrum Profiling of Drug Safety via Learning Complex Network

E3 Ubiquitin Ligase March1 Facilitates OX40L Expression in Allergen-Stimulated Dendritic Cells Through Mediating the Ubiquitination of HDAC11

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