Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases

Abstract

Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective substrates for intracellular degradation. Still, we do not understand how ubiquitin proteasome system-based enzymes E3 ubiquitin ligases do their

Systematic analysis of alternative splicing in time course data using Spycone

“…A previous study showed that clustering performance is highly dependent on the dataset and the clustering method ( Javed et al , 2020 ). Therefore, Spycone offers various clustering techniques, including agglomerative clustering (hierarchical clustering) (Johnson, 1967 ), K-Means clustering (Hartigan and Wong, 1979 ), K-Medoids clustering (Park and Jun, 2009 ), DBSCAN ( Ester et al , 1996 ), OPTICS ( Ankerst et al , 1999 ) and various distance metrics such as euclidean distance, Pearson distance, as well as tslearn ( Tavenard et al , 2020 ) for calculating the dynamic time warping distance measure.…”

Systematic analysis of alternative splicing in time course data using Spycone

“…They are known to mediate host immune response by removing virus particles. Various virus species hijack the host E3 ubiquitin ligases in favor of viral protein production [44]. They are also involved in maintaining TMPRSS2 stabilization during virus entry to the host cells [45].…”